Genular: Defining Cellular Identity and Function

Details for: Ppp3r1

Gene ID: 19058

Symbol: Ppp3r1

Ensembl ID: ENSMUSG00000033953

Description: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)

Associated with

Activation of bad and translocation to mitochondria
(R-MMU-111447)
Activation of bh3-only proteins
(R-MMU-114452)
Adaptive immune system
(R-MMU-1280218)
Apoptosis
(R-MMU-109581)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Ca2+ pathway
(R-MMU-4086398)
Calcineurin activates nfat
(R-MMU-2025928)
Clec7a (dectin-1) induces nfat activation
(R-MMU-5607763)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated ca+2 mobilization
(R-MMU-2871809)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Intrinsic pathway for apoptosis
(R-MMU-109606)
Programmed cell death
(R-MMU-5357801)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Calcineurin-mediated signaling
(GO:0097720)
Calcineurin-nfat signaling cascade
(GO:0033173)
Calcineurin complex
(GO:0005955)
Calcium-dependent protein serine/threonine phosphatase regulator activity
(GO:0008597)
Calcium ion binding
(GO:0005509)
Cyclosporin a binding
(GO:0016018)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Epithelial to mesenchymal transition
(GO:0001837)
Glutamatergic synapse
(GO:0098978)
Heart development
(GO:0007507)
Hippocampal mossy fiber to ca3 synapse
(GO:0098686)
Lung epithelial cell differentiation
(GO:0060487)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Myelination in peripheral nervous system
(GO:0022011)
Negative regulation of calcium ion import across plasma membrane
(GO:1905949)
Parallel fiber to purkinje cell synapse
(GO:0098688)
Phosphatase binding
(GO:0019902)
Phosphoprotein phosphatase activity
(GO:0004721)
Plasma membrane
(GO:0005886)
Positive regulation of calcineurin-nfat signaling cascade
(GO:0070886)
Positive regulation of calcium ion import across plasma membrane
(GO:1905665)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Postsynapse
(GO:0098794)
Postsynaptic modulation of chemical synaptic transmission
(GO:0099170)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein domain specific binding
(GO:0019904)
Protein import into nucleus
(GO:0006606)
Protein localization to nucleus
(GO:0034504)
Protein serine/threonine phosphatase complex
(GO:0008287)
Regulation of postsynaptic neurotransmitter receptor internalization
(GO:0099149)
Regulation of synaptic vesicle cycle
(GO:0098693)
Sarcolemma
(GO:0042383)
Schaffer collateral - ca1 synapse
(GO:0098685)
Schwann cell development
(GO:0014044)
Synapse
(GO:0045202)

Other Information

Proteins

Calcineurin subunit B type 1

Genular Protein ID: 1865693937

Symbol: CANB1_MOUSE

Name: Calcineurin subunit B type 1

UniProtKB Accession Codes:

Q63810 Q3V067 Q5F225

Database IDs:

Citations:

PubMed ID: 1325794

Title: Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B).

PubMed ID: 1325794

DOI: 10.1016/s0006-291x(05)81527-x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 16286645

Title: Calcineurin regulates bone formation by the osteoblast.

PubMed ID: 16286645

DOI: 10.1073/pnas.0508480102

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20639889

Title: CIB1 is a regulator of pathological cardiac hypertrophy.

PubMed ID: 20639889

DOI: 10.1038/nm.2181

PubMed ID: 26794871

Title: Cooperative autoinhibition and multi-level activation mechanisms of calcineurin.

PubMed ID: 26794871

DOI: 10.1038/cr.2016.14

Sequence Information:

Length: 170
Mass: 19300
Checksum: C904715DC0386056
Sequence:

MGNEASYPLE MCSHFDADEI KRLGKRFKKL DLDNSGSLSV EEFMSLPELQ QNPLVQRVID 
IFDTDGNGEV DFKEFIEGVS QFSVKGDKEQ KLRFAFRIYD MDKDGYISNG ELFQVLKMMV 
GNNLKDTQLQ QIVDKTIINA DKDGDGRISF EEFCAVVGGL DIHKKMVVDV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ppp3r1

Associated with

Other Information

Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B). PubMed ID: 1325794

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Calcineurin regulates bone formation by the osteoblast. PubMed ID: 16286645

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

CIB1 is a regulator of pathological cardiac hypertrophy. PubMed ID: 20639889

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. PubMed ID: 26794871