Genular: Defining Cellular Identity and Function

Details for: Ppp5c

Gene ID: 19060

Symbol: Ppp5c

Ensembl ID: ENSMUSG00000003099

Description: protein phosphatase 5, catalytic subunit

Associated with

Dna double-strand break repair
(R-MMU-5693532)
Dna double strand break response
(R-MMU-5693606)
Dna repair
(R-MMU-73894)
Esr-mediated signaling
(R-MMU-8939211)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of mapk pathway
(R-MMU-5675221)
Raf/map kinase cascade
(R-MMU-5673001)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-MMU-5693565)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
Adp binding
(GO:0043531)
Atp binding
(GO:0005524)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
G-protein alpha-subunit binding
(GO:0001965)
Heat shock protein binding
(GO:0031072)
Hsp90 protein binding
(GO:0051879)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Microtubule binding
(GO:0008017)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of protein phosphorylation
(GO:0001933)
Neuronal cell body
(GO:0043025)
Nucleus
(GO:0005634)
Peptidyl-serine dephosphorylation
(GO:0070262)
Perikaryon
(GO:0043204)
Phosphatase activity
(GO:0016791)
Phosphoprotein phosphatase activity
(GO:0004721)
Plasma membrane
(GO:0005886)
Positive regulation of glucocorticoid receptor signaling pathway
(GO:2000324)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein folding chaperone complex
(GO:0101031)
Protein serine/threonine phosphatase activity
(GO:0004722)
Proximal dendrite
(GO:1990635)
Response to arachidonic acid
(GO:1904550)
Response to lead ion
(GO:0010288)
Response to morphine
(GO:0043278)
Rna binding
(GO:0003723)

Other Information

Proteins

Serine/threonine-protein phosphatase 5

Genular Protein ID: 2928124123

Symbol: PPP5_MOUSE

Name: Serine/threonine-protein phosphatase 5

UniProtKB Accession Codes:

Q60676 G5E819 O35299

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7972012

Title: Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor.

PubMed ID: 7972012

DOI: 10.1073/pnas.91.23.11075

PubMed ID: 9195923

Title: Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin.

PubMed ID: 9195923

DOI: 10.1074/jbc.272.26.16224

PubMed ID: 12522145

Title: Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.

PubMed ID: 12522145

DOI: 10.1074/jbc.m212632200

PubMed ID: 16790549

Title: Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.

PubMed ID: 16790549

DOI: 10.1073/pnas.0604138103

PubMed ID: 17376776

Title: Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest.

PubMed ID: 17376776

DOI: 10.1074/jbc.c700019200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21994940

Title: Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-? (PPAR?).

PubMed ID: 21994940

DOI: 10.1074/jbc.m111.311662

PubMed ID: 22526606

Title: Serine/threonine protein phosphatase 5 regulates glucose homeostasis in vivo and apoptosis signalling in mouse pancreatic islets and clonal MIN6 cells.

PubMed ID: 22526606

DOI: 10.1007/s00125-012-2541-1

Sequence Information:

Length: 499
Mass: 56877
Checksum: 92C5509374FD6721
Sequence:

MAMAEGERTE CAETPRDEPP ADGTLKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPG 
NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE 
TVVKVKPNDK DAKMKYQECS KIVKQKAFER AIAGDEHRRS VVDSLDIESM TIEDEYSGPK 
LEDGKVTITF MKDLMQWYKD QKKLHRKCAY QILVQVKEVL CKLSTLVETT LKETEKITVC 
GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 
RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 
VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSVSKR GVSCQFGPDV TKAFLEENQL 
DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP 
HPNVKPMAYA NTLLQLGMM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ppp5c

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor. PubMed ID: 7972012

Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. PubMed ID: 9195923

Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. PubMed ID: 12522145

Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5. PubMed ID: 16790549

Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest. PubMed ID: 17376776

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-? (PPAR?). PubMed ID: 21994940

Serine/threonine protein phosphatase 5 regulates glucose homeostasis in vivo and apoptosis signalling in mouse pancreatic islets and clonal MIN6 cells. PubMed ID: 22526606