Genular: Defining Cellular Identity and Function

Details for: Inpp5k

Gene ID: 19062

Symbol: Inpp5k

Ensembl ID: ENSMUSG00000006127

Description: inositol polyphosphate 5-phosphatase K

Associated with

Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Phospholipid metabolism
(R-MMU-1483257)
Pi metabolism
(R-MMU-1483255)
Synthesis of pips at the plasma membrane
(R-MMU-1660499)
Catalytic activity
(GO:0003824)
Cellular response to camp
(GO:0071320)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Cellular response to hormone stimulus
(GO:0032870)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to tumor necrosis factor
(GO:0071356)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dephosphorylation
(GO:0016311)
Endoplasmic reticulum
(GO:0005783)
Glucose homeostasis
(GO:0042593)
G protein-coupled receptor signaling pathway
(GO:0007186)
Hydrolase activity
(GO:0016787)
Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
(GO:0052659)
Inositol-1,4,5-trisphosphate 5-phosphatase activity
(GO:0052658)
Inositol-polyphosphate 5-phosphatase activity
(GO:0004445)
Inositol bisphosphate phosphatase activity
(GO:0016312)
Inositol trisphosphate phosphatase activity
(GO:0046030)
In utero embryonic development
(GO:0001701)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Negative regulation by host of viral transcription
(GO:0043922)
Negative regulation of calcium ion transport
(GO:0051926)
Negative regulation of dephosphorylation
(GO:0035305)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of glucose transmembrane transport
(GO:0010829)
Negative regulation of glycogen (starch) synthase activity
(GO:2000466)
Negative regulation of glycogen biosynthetic process
(GO:0045719)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of peptidyl-threonine phosphorylation
(GO:0010801)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of protein targeting to membrane
(GO:0090315)
Negative regulation of single stranded viral rna replication via double stranded dna intermediate
(GO:0045869)
Negative regulation of stress fiber assembly
(GO:0051497)
Neuron projection
(GO:0043005)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatase activity
(GO:0016791)
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
(GO:0034485)
Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
(GO:0004439)
Phosphatidylinositol dephosphorylation
(GO:0046856)
Phosphatidylinositol phosphate 5-phosphatase activity
(GO:0034595)
Phosphatidylinositol trisphosphate phosphatase activity
(GO:0034594)
Plasma membrane
(GO:0005886)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of renal water transport
(GO:2001153)
Positive regulation of urine volume
(GO:0035810)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Regulation of glycogen biosynthetic process
(GO:0005979)
Response to insulin
(GO:0032868)
Ruffle
(GO:0001726)
Ruffle assembly
(GO:0097178)
Ruffle membrane
(GO:0032587)
Trans-golgi network
(GO:0005802)
Vasopressin receptor activity
(GO:0005000)

Other Information

Proteins

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

Genular Protein ID: 3086134755

Symbol: INP5K_MOUSE

Name: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

UniProtKB Accession Codes:

Q8C5L6 O09040

Database IDs:

Citations:

PubMed ID: 9182797

Title: The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression.

PubMed ID: 9182797

DOI: 10.1016/s0896-6273(00)80312-8

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22247557

Title: Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).

PubMed ID: 22247557

DOI: 10.1074/jbc.m111.335539

PubMed ID: 22751929

Title: Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1.

PubMed ID: 22751929

DOI: 10.1128/mcb.00636-12

PubMed ID: 28190456

Title: Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital muscular dystrophy with cataracts and mild cognitive impairment.

PubMed ID: 28190456

DOI: 10.1016/j.ajhg.2017.01.024

Sequence Information:

Length: 468
Mass: 54159
Checksum: F2E1CA370B97A8A1
Sequence:

MQHGDRNTPG YREGIMSAVS LRRPSAPKGF ALSVHVVTWN VASAAPTVDL SDLLQLNNQD 
LNLDIYIIGL QEMNFGIISL LSDAAFEDPW SSLFMDMLSP LNFVKISQVR MQGLLLLVFA 
KYQHLPYIQI ISTKSTPTGL YGYWGNKGGV NVCLKLYGYY VSIINCHLPP HMYNNDQRLE 
HFDRILESLT FEGYDVPNIL DHDLILWFGD MNFRIEDFGL LFVQESITRK YYKELWEKDQ 
LFIAKKNDQL LREFQEGPLL FPPTYKFDRH SNNYDTSEKK RKPAWTDRIL WRLKRQPSQA 
SPLASSVPTS YFLLTLKNYV SHMAYSISDH KPVTGTFDLE LNPLMSVPLI TMMPEHLWTM 
ENDMLISYTS TPEFLSSSWD WIGLYKVGMR HINDYVAYVW VGDNQVSYGN NPNQVYINIS 
AIPDTEDQFL LCYYSNNLHS VVGISQPFKI PIRSFLREDT LYEPEPQI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Inpp5k

Associated with

Other Information

The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. PubMed ID: 9182797

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP). PubMed ID: 22247557

Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1. PubMed ID: 22751929

Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital muscular dystrophy with cataracts and mild cognitive impairment. PubMed ID: 28190456