Genular: Defining Cellular Identity and Function

Details for: Srgn

Gene ID: 19073

Symbol: Srgn

Ensembl ID: ENSMUSG00000020077

Description: serglycin

Associated with

Hemostasis
(R-MMU-109582)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Apoptotic process
(GO:0006915)
Biomineral tissue development
(GO:0031214)
Collagen binding
(GO:0005518)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glutamatergic synapse
(GO:0098978)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Granzyme-mediated programmed cell death signaling pathway
(GO:0140507)
Lysosome
(GO:0005764)
Maintenance of granzyme b location in t cell secretory granule
(GO:0033382)
Maintenance of protease location in mast cell secretory granule
(GO:0033373)
Mast cell granule
(GO:0042629)
Mast cell secretory granule organization
(GO:0033364)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of bone mineralization
(GO:0030502)
Negative regulation of cytokine production
(GO:0001818)
Postsynaptic specialization, intracellular component
(GO:0099091)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)
Regulation of postsynapse organization
(GO:0099175)
Schaffer collateral - ca1 synapse
(GO:0098685)
Secretory granule
(GO:0030141)
Secretory granule organization
(GO:0033363)
T cell secretory granule organization
(GO:0033371)
Zymogen granule
(GO:0042588)

Other Information

Proteins

Serglycin

Genular Protein ID: 4067288444

Symbol: SRGN_MOUSE

Name: Serglycin

UniProtKB Accession Codes:

P13609 Q3TZD4 Q8C2U2

Database IDs:

Citations:

PubMed ID: 2532501

Title: Primary structure of a mouse mastocytoma proteoglycan core protein.

PubMed ID: 2532501

DOI: 10.1042/bj2630105

PubMed ID: 2777804

Title: Cloning and characterization of the mouse gene that encodes the peptide core of secretory granule proteoglycans and expression of this gene in transfected rat-1 fibroblasts.

PubMed ID: 2777804

DOI: 10.1016/s0021-9258(19)84764-6

PubMed ID: 2726751

Title: Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA.

PubMed ID: 2726751

DOI: 10.1073/pnas.86.10.3763

PubMed ID: 2121613

Title: Cloning and structural analysis of a gene encoding a mouse mastocytoma proteoglycan core protein; analysis of its evolutionary relation to three cross hybridizing regions in the mouse genome.

PubMed ID: 2121613

DOI: 10.1016/0378-1119(90)90230-o

PubMed ID: 8502243

Title: Induction of a proteoglycan core protein mRNA in mouse T lymphocytes.

PubMed ID: 8502243

DOI: 10.1016/0161-5890(93)90146-3

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7535771

Title: A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. Possible involvement in lymphoid cell adherence and activation.

PubMed ID: 7535771

DOI: 10.1074/jbc.270.13.7437

PubMed ID: 15231821

Title: Serglycin is essential for maturation of mast cell secretory granule.

PubMed ID: 15231821

DOI: 10.1074/jbc.m405856200

PubMed ID: 16046402

Title: Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage.

PubMed ID: 16046402

DOI: 10.1074/jbc.m501708200

PubMed ID: 17081126

Title: Mast cell-dependent activation of pro matrix metalloprotease 2: a role for serglycin proteoglycan-dependent mast cell proteases.

PubMed ID: 17081126

DOI: 10.1515/bc.2006.189

PubMed ID: 17010166

Title: A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components.

PubMed ID: 17010166

DOI: 10.1111/j.1742-4658.2006.05489.x

PubMed ID: 16807245

Title: Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide.

PubMed ID: 16807245

DOI: 10.1074/jbc.m512889200

PubMed ID: 17147513

Title: Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells.

PubMed ID: 17147513

DOI: 10.1042/bj20061257

PubMed ID: 17272511

Title: Neutrophil elastase depends on serglycin proteoglycan for localization in granules.

PubMed ID: 17272511

DOI: 10.1182/blood-2006-02-001719

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 152
Mass: 16711
Checksum: DCEC9829BA31036F
Sequence:

MQVPVGSRLV LALAFVLVWG SSVQGYPARR ARYQWVRCKP NGFFANCIEE KGPQFDLIDE 
SNNIGPPMNN PVLMEGPSKD FISNYDDYGS GSGSGSGSGS GSGSGSGSGF LGDMEWEYQP 
TDESNIVYFN YKPFDRILTE QNQDQPEDDF II

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Srgn

Associated with

Other Information

Primary structure of a mouse mastocytoma proteoglycan core protein. PubMed ID: 2532501

Cloning and characterization of the mouse gene that encodes the peptide core of secretory granule proteoglycans and expression of this gene in transfected rat-1 fibroblasts. PubMed ID: 2777804

Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA. PubMed ID: 2726751

Cloning and structural analysis of a gene encoding a mouse mastocytoma proteoglycan core protein; analysis of its evolutionary relation to three cross hybridizing regions in the mouse genome. PubMed ID: 2121613

Induction of a proteoglycan core protein mRNA in mouse T lymphocytes. PubMed ID: 8502243

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. Possible involvement in lymphoid cell adherence and activation. PubMed ID: 7535771

Serglycin is essential for maturation of mast cell secretory granule. PubMed ID: 15231821

Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage. PubMed ID: 16046402

Mast cell-dependent activation of pro matrix metalloprotease 2: a role for serglycin proteoglycan-dependent mast cell proteases. PubMed ID: 17081126

A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components. PubMed ID: 17010166

Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide. PubMed ID: 16807245

Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells. PubMed ID: 17147513

Neutrophil elastase depends on serglycin proteoglycan for localization in granules. PubMed ID: 17272511

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079