Genular: Defining Cellular Identity and Function

Details for: Prim1

Gene ID: 19075

Symbol: Prim1

Ensembl ID: ENSMUSG00000025395

Description: DNA primase, p49 subunit

Associated with

Activation of the pre-replicative complex
(R-MMU-68962)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Chromosome maintenance
(R-MMU-73886)
Dna replication pre-initiation
(R-MMU-69002)
Dna strand elongation
(R-MMU-69190)
E2f mediated regulation of dna replication
(R-MMU-113510)
Extension of telomeres
(R-MMU-180786)
G1/s transition
(R-MMU-69206)
Inhibition of replication initiation of damaged dna by rb1/e2f1
(R-MMU-113501)
Lagging strand synthesis
(R-MMU-69186)
Leading strand synthesis
(R-MMU-69109)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Polymerase switching
(R-MMU-69091)
Polymerase switching on the c-strand of the telomere
(R-MMU-174411)
Processive synthesis on the lagging strand
(R-MMU-69183)
Removal of the flap intermediate
(R-MMU-69166)
S phase
(R-MMU-69242)
Synthesis of dna
(R-MMU-69239)
Telomere c-strand (lagging strand) synthesis
(R-MMU-174417)
Telomere c-strand synthesis initiation
(R-MMU-174430)
Telomere maintenance
(R-MMU-157579)
Alpha dna polymerase:primase complex
(GO:0005658)
Dna-directed rna polymerase complex
(GO:0000428)
Dna primase activity
(GO:0003896)
Dna replication
(GO:0006260)
Dna replication, synthesis of rna primer
(GO:0006269)
Dna replication initiation
(GO:0006270)
Magnesium ion binding
(GO:0000287)
Metal ion binding
(GO:0046872)
Nucleotidyltransferase activity
(GO:0016779)
Primosome complex
(GO:1990077)
Protein binding
(GO:0005515)
Ribonucleotide binding
(GO:0032553)
Transferase activity
(GO:0016740)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

DNA primase small subunit

Genular Protein ID: 1821545212

Symbol: PRI1_MOUSE

Name: DNA primase small subunit

UniProtKB Accession Codes:

P20664

Database IDs:

Citations:

PubMed ID: 2925677

Title: Mouse primase p49 subunit molecular cloning indicates conserved and divergent regions.

PubMed ID: 2925677

DOI: 10.1016/s0021-9258(18)83684-5

PubMed ID: 8463324

Title: Molecular cloning of the cDNAs for the four subunits of mouse DNA polymerase alpha-primase complex and their gene expression during cell proliferation and the cell cycle.

PubMed ID: 8463324

DOI: 10.1016/s0021-9258(18)53069-6

PubMed ID: 8253737

Title: Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication.

PubMed ID: 8253737

DOI: 10.1016/s0021-9258(19)74297-5

PubMed ID: 8026492

Title: DNA replication in vitro by recombinant DNA-polymerase-alpha-primase.

PubMed ID: 8026492

DOI: 10.1111/j.1432-1033.1994.tb18925.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 417
Mass: 49295
Checksum: 54EBF4DA4DE47D8A
Sequence:

MEPFDPAELP ELLKLYYRRL FPYAQYYRWL NYGGVTKNYF QHREFSFTLK DDIYIRYQSF 
NNQSELEKEM QKMNPYKIDI GAVYSHRPNQ HNTVKLGAFQ AQEKELVFDI DMTDYDDVRR 
CCSSADICSK CWTLMTMAMR IIDRALKEDF GFKHRLWVYS GRRGVHCWVC DESVRKLSSA 
VRSGIVEYLS LVKGGQDVKK KVHLNEKVHP FVRKSINIIK KYFEEYALVG QDILENKENW 
DKILALVPET IHDELQRGFQ KFHSSPQRWE HLRKVANSSQ NMKNDKCGPW LEWEVMLQYC 
FPRLDVNVSK GVNHLLKSPF SVHPKTGRIS VPIDFHKVDQ FDPFTVPTIS AICRELDMVS 
THEKEKEENE ADSKHRVRGY KKTSLAPYVK VFEQFLENLD KSRKGELLKK SDLQKDF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prim1

Associated with

Other Information

Mouse primase p49 subunit molecular cloning indicates conserved and divergent regions. PubMed ID: 2925677

Molecular cloning of the cDNAs for the four subunits of mouse DNA polymerase alpha-primase complex and their gene expression during cell proliferation and the cell cycle. PubMed ID: 8463324

Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication. PubMed ID: 8253737