Genular: Defining Cellular Identity and Function

Details for: Prim2

Gene ID: 19076

Symbol: Prim2

Ensembl ID: ENSMUSG00000026134

Description: DNA primase, p58 subunit

Associated with

Activation of the pre-replicative complex
(R-MMU-68962)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Chromosome maintenance
(R-MMU-73886)
Dna replication pre-initiation
(R-MMU-69002)
Dna strand elongation
(R-MMU-69190)
E2f mediated regulation of dna replication
(R-MMU-113510)
Extension of telomeres
(R-MMU-180786)
G1/s transition
(R-MMU-69206)
Inhibition of replication initiation of damaged dna by rb1/e2f1
(R-MMU-113501)
Lagging strand synthesis
(R-MMU-69186)
Leading strand synthesis
(R-MMU-69109)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Polymerase switching
(R-MMU-69091)
Polymerase switching on the c-strand of the telomere
(R-MMU-174411)
Processive synthesis on the lagging strand
(R-MMU-69183)
Removal of the flap intermediate
(R-MMU-69166)
S phase
(R-MMU-69242)
Synthesis of dna
(R-MMU-69239)
Telomere c-strand (lagging strand) synthesis
(R-MMU-174417)
Telomere c-strand synthesis initiation
(R-MMU-174430)
Telomere maintenance
(R-MMU-157579)
4 iron, 4 sulfur cluster binding
(GO:0051539)
Alpha dna polymerase:primase complex
(GO:0005658)
Dna/rna hybrid binding
(GO:0071667)
Dna binding
(GO:0003677)
Dna replication
(GO:0006260)
Dna replication, synthesis of rna primer
(GO:0006269)
Dna replication initiation
(GO:0006270)
Iron-sulfur cluster binding
(GO:0051536)
Metal ion binding
(GO:0046872)
Positive regulation of dna primase activity
(GO:1903934)
Primosome complex
(GO:1990077)

Other Information

Proteins

DNA primase large subunit

Genular Protein ID: 4043184065

Symbol: PRI2_MOUSE

Name: DNA primase large subunit

UniProtKB Accession Codes:

P33610 Q3U4Z3

Database IDs:

Citations:

PubMed ID: 8463324

Title: Molecular cloning of the cDNAs for the four subunits of mouse DNA polymerase alpha-primase complex and their gene expression during cell proliferation and the cell cycle.

PubMed ID: 8463324

DOI: 10.1016/s0021-9258(18)53069-6

PubMed ID: 8026492

Title: DNA replication in vitro by recombinant DNA-polymerase-alpha-primase.

PubMed ID: 8026492

DOI: 10.1111/j.1432-1033.1994.tb18925.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8253737

Title: Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication.

PubMed ID: 8253737

DOI: 10.1016/s0021-9258(19)74297-5

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 505
Mass: 58408
Checksum: 36A64C77669D8C24
Sequence:

MQFSGRIRKK LRLAGDQRNA SYPHSLQFYL QPPTENISLT EFENLAFDRV KLLKAIENLG 
VSYVKGTEQY QSKLEAEIRK LKFSYRENLE DEYEPRRRDH ISHFILRLAY CQSEDLRRWF 
IQQEMDLLRF RFSILPKDKV QSFLKDSHLH FEAISDEEKT LREQDIMASS PSLSGIKLES 
ESVYKVPFAD ALDLFRGRKV YLEDGFAYVP LKDIVAIILN EFRATLSKAL ALTARSLPAV 
QSDERLQPLL NHLSHSYTGQ DYSTQKNTGK ISLDQIDSLS TKSFPPCMRQ LHKALRENHH 
LRHGGRMQYG LFLKGIGLTL EQALQFWKQE FIRGKMDPDK FDKGYSYNIR HSFGKEGKRT 
DYTPFSCMKI ILTNPPGQGD YHGCPFRHSD AELLKQKMQS YKIPASGISQ ILDLVKGNHY 
QVACQKYFEM THNVDDCGFS LNHPNQFFFE SQRILTGGKD IKKEISQPET PQHKPSTQKT 
RDAASALASL DSSLEMDLEG LEEYF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prim2

Associated with

Other Information

Molecular cloning of the cDNAs for the four subunits of mouse DNA polymerase alpha-primase complex and their gene expression during cell proliferation and the cell cycle. PubMed ID: 8463324

DNA replication in vitro by recombinant DNA-polymerase-alpha-primase. PubMed ID: 8026492

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication. PubMed ID: 8253737