Genular: Defining Cellular Identity and Function

Details for: Prkg1

Gene ID: 19091

Symbol: Prkg1

Ensembl ID: ENSMUSG00000052920

Description: protein kinase, cGMP-dependent, type I

Associated with

Adaptive immune system
(R-MMU-1280218)
Cgmp effects
(R-MMU-418457)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Nitric oxide stimulates guanylate cyclase
(R-MMU-392154)
Platelet homeostasis
(R-MMU-418346)
Rap1 signalling
(R-MMU-392517)
Atp binding
(GO:0005524)
Calcium channel regulator activity
(GO:0005246)
Catalytic activity
(GO:0003824)
Cgmp-dependent protein kinase activity
(GO:0004692)
Cgmp-mediated signaling
(GO:0019934)
Cgmp binding
(GO:0030553)
Collateral sprouting
(GO:0048668)
Cytoplasm
(GO:0005737)
Dendrite development
(GO:0016358)
Forebrain development
(GO:0030900)
Golgi apparatus
(GO:0005794)
Identical protein binding
(GO:0042802)
Kinase activity
(GO:0016301)
Metabolic process
(GO:0008152)
Negative regulation of platelet aggregation
(GO:0090331)
Negative regulation of smooth muscle contraction
(GO:0045986)
Negative regulation of vascular associated smooth muscle cell migration
(GO:1904753)
Negative regulation of vascular associated smooth muscle cell proliferation
(GO:1904706)
Neuron migration
(GO:0001764)
Nucleotide binding
(GO:0000166)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Regulation of gtpase activity
(GO:0043087)
Relaxation of vascular associated smooth muscle
(GO:0060087)
Signal transduction
(GO:0007165)
Transferase activity
(GO:0016740)

Other Information

Proteins

cGMP-dependent protein kinase 1

Genular Protein ID: 2187882111

Symbol: KGP1_MOUSE

Name: cGMP-dependent protein kinase 1

UniProtKB Accession Codes:

P0C605 Q14DK6 Q9Z0Z0

Database IDs:

Citations:

PubMed ID: 10085070

Title: Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene transcription.

PubMed ID: 10085070

DOI: 10.1074/jbc.274.13.8391

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9606187

Title: Defective smooth muscle regulation in cGMP kinase I-deficient mice.

PubMed ID: 9606187

DOI: 10.1093/emboj/17.11.3045

PubMed ID: 9920894

Title: Phosphorylation-dependent inhibition of protein phosphatase-1 by G-substrate: a Purkinje cell substrate of the cyclic GMP-dependent protein kinase.

PubMed ID: 9920894

DOI: 10.1074/jbc.274.6.3485

PubMed ID: 10209042

Title: Increased adhesion and aggregation of platelets lacking cyclic guanosine 3',5'-monophosphate kinase I.

PubMed ID: 10209042

DOI: 10.1084/jem.189.8.1255

PubMed ID: 11055988

Title: Mechanisms of NO/cGMP-dependent vasorelaxation.

PubMed ID: 11055988

DOI: 10.1161/01.res.87.9.825

PubMed ID: 16154279

Title: Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina.

PubMed ID: 16154279

DOI: 10.1016/j.neuroscience.2005.06.051

PubMed ID: 16990611

Title: IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.

PubMed ID: 16990611

DOI: 10.1182/blood-2005-10-026294

PubMed ID: 19156199

Title: cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness.

PubMed ID: 19156199

DOI: 10.1371/journal.pone.0004238

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 671
Mass: 76350
Checksum: 51878E2D27F26A22
Sequence:

MSELEEDFAK ILMLKEERIK ELEKRLSEKE EEIQELKRKL HKCQSVLPVP STHIGPRTTR 
AQGISAEPQT YRSFHDLRQA FRKFTKSERS KDLIKEAILD NDFMKNLELS QIQEIVDCMY 
PVEYGKDSCI IKEGDVGSLV YVMEDGKVEV TKEGVKLCTM GPGKVFGELA ILYNCTRTAT 
VKTLVNVKLW AIDRQCFQTI MMRTGLIKHT EYMEFLKSVP TFQSLPDEIL SKLADVLEET 
HYENGEYIIR QGARGDTFFI ISKGQVNVTR EDSPSEDPVF LRTLGKGDWF GEKALQGEDV 
RTANVIAAEA VTCLVIDRDS FKHLIGGLDD VSNKAYEDAE AKAKYEAEAA FFANLKLSDF 
NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 
IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 
IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 
YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS 
ERLGNLKNGV KDIQKHKWFE GFNWEGLRKG TLTPPIIPSV ASPTDTSNFD SFPEDSDEPP 
PDDNSGWDID F

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prkg1

Associated with

Other Information

Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene transcription. PubMed ID: 10085070

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Defective smooth muscle regulation in cGMP kinase I-deficient mice. PubMed ID: 9606187

Phosphorylation-dependent inhibition of protein phosphatase-1 by G-substrate: a Purkinje cell substrate of the cyclic GMP-dependent protein kinase. PubMed ID: 9920894

Increased adhesion and aggregation of platelets lacking cyclic guanosine 3',5'-monophosphate kinase I. PubMed ID: 10209042

Mechanisms of NO/cGMP-dependent vasorelaxation. PubMed ID: 11055988

Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina. PubMed ID: 16154279

IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. PubMed ID: 16990611

cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness. PubMed ID: 19156199

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079