Genular: Defining Cellular Identity and Function

Details for: Mapk11

Gene ID: 19094

Symbol: Mapk11

Ensembl ID: ENSMUSG00000053137

Description: mitogen-activated protein kinase 11

Associated with

Activated tak1 mediates p38 mapk activation
(R-MMU-450302)
Activation of the ap-1 family of transcription factors
(R-MMU-450341)
Axon guidance
(R-MMU-422475)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Dscam interactions
(R-MMU-376172)
Erk/mapk targets
(R-MMU-198753)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-17 signaling
(R-MMU-448424)
Map kinase activation
(R-MMU-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-MMU-450282)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Myogenesis
(R-MMU-525793)
Nervous system development
(R-MMU-9675108)
Netrin-1 signaling
(R-MMU-373752)
Nod1/2 signaling pathway
(R-MMU-168638)
Nuclear events (kinase and transcription factor activation)
(R-MMU-198725)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-MMU-168643)
Oxidative stress induced senescence
(R-MMU-2559580)
P38mapk events
(R-MMU-171007)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate nadph oxidases
(R-MMU-5668599)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by interleukins
(R-MMU-449147)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by vegf
(R-MMU-194138)
Signalling to erks
(R-MMU-187687)
Signalling to ras
(R-MMU-167044)
Signal transduction
(R-MMU-162582)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Transcriptional regulation by tp53
(R-MMU-3700989)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Atp binding
(GO:0005524)
Bone development
(GO:0060348)
Cardiac muscle cell proliferation
(GO:0060038)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to uv-b
(GO:0071493)
Cellular response to virus
(GO:0098586)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Mapk cascade
(GO:0000165)
Map kinase activity
(GO:0004707)
Negative regulation of cardiac muscle cell proliferation
(GO:0060044)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
P38mapk cascade
(GO:0038066)
Phosphorylation
(GO:0016310)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-12 production
(GO:0032735)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of cardiac muscle cell proliferation
(GO:0060043)
Stress-activated mapk cascade
(GO:0051403)
Stress-activated protein kinase signaling cascade
(GO:0031098)
Transferase activity
(GO:0016740)

Other Information

Proteins

Mitogen-activated protein kinase 11

Genular Protein ID: 3569757196

Symbol: MK11_MOUSE

Name: Mitogen-activated protein kinase 11

UniProtKB Accession Codes:

Q9WUI1 Q569F1

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11909979

Title: MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.

PubMed ID: 11909979

DOI: 10.1128/mcb.22.8.2871-2881.2002

PubMed ID: 20004242

Title: Differential activation of p38MAPK isoforms by MKK6 and MKK3.

PubMed ID: 20004242

DOI: 10.1016/j.cellsig.2009.11.020

PubMed ID: 12452429

Title: In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance.

PubMed ID: 12452429

DOI: 10.1515/bc.2002.173

PubMed ID: 20626350

Title: Mechanisms and functions of p38 MAPK signalling.

PubMed ID: 20626350

DOI: 10.1042/bj20100323

Sequence Information:

Length: 364
Mass: 41397
Checksum: 75C16E9972508220
Sequence:

MSGPRAGFYR QELNKTVWEV PQRLQGLRPV GSGAYGSVCS AYDARLRQKV AVKKLSRPFQ 
SLIHARRTYR ELRLLKHLKH ENVIGLLDVF TPATSIEDFS EVYLVTTLMG ADLNNIVKCQ 
ALSDEHVQFL VYQLLRGLKY IHSAGIIHRD LKPSNVAVNE DCELRILDFG LARQADEEMT 
GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLQGK ALFPGNDYID QLKRIMEVVG 
TPSPEVLAKI SSEHARTYIQ SLPPMPQKDL SSVFHGANPL AIDLLGRMLV LDSDQRVSAA 
EALAHAYFSQ YHDPDDEPEA EPYDESVEAK ERTLEEWKEL TYQEVLSFKP LEPSQLPGTH 
EIEQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mapk11

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. PubMed ID: 11909979

Differential activation of p38MAPK isoforms by MKK6 and MKK3. PubMed ID: 20004242