Genular: Defining Cellular Identity and Function

Details for: Eif2ak2

Gene ID: 19106

Symbol: Eif2ak2

Ensembl ID: ENSMUSG00000024079

Description: eukaryotic translation initiation factor 2-alpha kinase 2

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Interferon signaling
(R-MMU-913531)
Isg15 antiviral mechanism
(R-MMU-1169408)
Pkr-mediated signaling
(R-MMU-9833482)
Antiviral innate immune response
(GO:0140374)
Atp binding
(GO:0005524)
Cellular response to amino acid starvation
(GO:0034198)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Double-stranded rna binding
(GO:0003725)
Eif2alpha phosphorylation in response to endoplasmic reticulum stress
(GO:0036492)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Eukaryotic translation initiation factor 2alpha kinase activity
(GO:0004694)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Kinase activity
(GO:0016301)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of osteoblast proliferation
(GO:0033689)
Negative regulation of translation
(GO:0017148)
Negative regulation of viral genome replication
(GO:0045071)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphorylation
(GO:0016310)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of stress-activated mapk cascade
(GO:0032874)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of hematopoietic progenitor cell differentiation
(GO:1901532)
Regulation of hematopoietic stem cell differentiation
(GO:1902036)
Regulation of hematopoietic stem cell proliferation
(GO:1902033)
Regulation of nlrp3 inflammasome complex assembly
(GO:1900225)
Response to interferon-alpha
(GO:0035455)
Response to lipopolysaccharide
(GO:0032496)
Response to toxic substance
(GO:0009636)
Response to virus
(GO:0009615)
Response to vitamin e
(GO:0033197)
Rna binding
(GO:0003723)
Transferase activity
(GO:0016740)
Translation
(GO:0006412)

Other Information

Proteins

Interferon-induced, double-stranded RNA-activated protein kinase

Genular Protein ID: 1331315497

Symbol: E2AK2_MOUSE

Name: Interferon-induced, double-stranded RNA-activated protein kinase

UniProtKB Accession Codes:

Q03963 Q61742 Q62026

Database IDs:

Citations:

PubMed ID: 1714905

Title: TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine.

PubMed ID: 1714905

DOI: 10.1016/s0021-9258(18)98517-0

PubMed ID: 1351683

Title: Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase.

PubMed ID: 1351683

DOI: 10.1073/pnas.89.12.5447

PubMed ID: 7914700

Title: Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase.

PubMed ID: 7914700

DOI: 10.1073/pnas.91.17.7995

PubMed ID: 7533117

Title: Sequence of the murine interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones.

PubMed ID: 7533117

DOI: 10.1016/0378-1119(94)00821-9

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10848580

Title: PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

PubMed ID: 10848580

DOI: 10.1128/mcb.20.13.4532-4542.2000

PubMed ID: 12882984

Title: Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR.

PubMed ID: 12882984

DOI: 10.1074/jbc.m301392200

PubMed ID: 17079286

Title: Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.

PubMed ID: 17079286

DOI: 10.1128/jvi.01527-06

PubMed ID: 19264662

Title: PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response.

PubMed ID: 19264662

DOI: 10.1099/vir.0.007336-0

PubMed ID: 19229320

Title: An antiviral response directed by PKR phosphorylation of the RNA helicase A.

PubMed ID: 19229320

DOI: 10.1371/journal.ppat.1000311

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20478537

Title: Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.

PubMed ID: 20478537

DOI: 10.1016/j.chom.2010.04.007

PubMed ID: 21123651

Title: Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense.

PubMed ID: 21123651

DOI: 10.1101/gad.1965010

PubMed ID: 20038207

Title: Double-stranded RNA-activated protein kinase regulates early innate immune responses during respiratory syncytial virus infection.

PubMed ID: 20038207

DOI: 10.1089/jir.2009.0051

PubMed ID: 20631127

Title: Protein kinase R is responsible for the phosphorylation of eIF2alpha in rotavirus infection.

PubMed ID: 20631127

DOI: 10.1128/jvi.00625-10

PubMed ID: 20585572

Title: Role of PKR and Type I IFNs in viral control during primary and secondary infection.

PubMed ID: 20585572

DOI: 10.1371/journal.ppat.1000966

PubMed ID: 21994357

Title: Protein kinase R is a novel mediator of CD40 signaling and plays a critical role in modulating immunoglobulin expression during respiratory syncytial virus infection.

PubMed ID: 21994357

DOI: 10.1128/cvi.05476-11

PubMed ID: 21300116

Title: Novel insights in the interplay between inflammation and metabolic diseases: a role for the pathogen sensing kinase PKR.

PubMed ID: 21300116

DOI: 10.1016/j.jhep.2010.11.037

PubMed ID: 22948222

Title: Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice.

PubMed ID: 22948222

DOI: 10.1210/en.2012-1400

PubMed ID: 22633459

Title: Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense.

PubMed ID: 22633459

DOI: 10.1016/j.immuni.2012.02.020

PubMed ID: 22801494

Title: Novel role of PKR in inflammasome activation and HMGB1 release.

PubMed ID: 22801494

DOI: 10.1038/nature11290

PubMed ID: 23403623

Title: PKR regulates proliferation, differentiation and survival of murine hematopoietic stem/progenitor cells.

PubMed ID: 23403623

DOI: 10.1182/blood-2012-09-456400

PubMed ID: 23401008

Title: The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages.

PubMed ID: 23401008

DOI: 10.1002/eji.201243187

PubMed ID: 23229543

Title: Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation.

PubMed ID: 23229543

DOI: 10.1074/jbc.m112.401851

PubMed ID: 23392680

Title: Blocking the eIF2? kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory.

PubMed ID: 23392680

DOI: 10.1523/jneurosci.2322-12.2013

Sequence Information:

Length: 515
Mass: 58280
Checksum: 7A116F7D8DB9B847
Sequence:

MASDTPGFYM DKLNKYRQMH GVAITYKELS TSGPPHDRRF TFQVLIDEKE FPEAKGRSKQ 
EARNAAAKLA VDILDNENKV DCHTSASEQG LFVGNYIGLV NSFAQKKKLS VNYEQCEPNS 
ELPQRFICKC KIGQTMYGTG SGVTKQEAKQ LAAKEAYQKL LKSPPKTAGT SSSVVTSTFS 
GFSSSSSMTS NGVSQSAPGS FSSENVFTNG LGENKRKSGV KVSPDDVQRN KYTLDARFNS 
DFEDIEEIGL GGFGQVFKAK HRIDGKRYAI KRVKYNTEKA EHEVQALAEL NHVNIVQYHS 
CWEGVDYDPE HSMSDTSRYK TRCLFIQMEF CDKGTLEQWM RNRNQSKVDK ALILDLYEQI 
VTGVEYIHSK GLIHRDLKPG NIFLVDERHI KIGDFGLATA LENDGKSRTR RTGTLQYMSP 
EQLFLKHYGK EVDIFALGLI LAELLHTCFT ESEKIKFFES LRKGDFSNDI FDNKEKSLLK 
KLLSEKPKDR PETSEILKTL AEWRNISEKK KRNTC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Eif2ak2

Associated with

Other Information

TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. PubMed ID: 1714905

Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase. PubMed ID: 1351683

Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase. PubMed ID: 7914700

Sequence of the murine interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones. PubMed ID: 7533117

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex. PubMed ID: 10848580

Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR. PubMed ID: 12882984

Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection. PubMed ID: 17079286

PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response. PubMed ID: 19264662

An antiviral response directed by PKR phosphorylation of the RNA helicase A. PubMed ID: 19229320

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. PubMed ID: 20478537

Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense. PubMed ID: 21123651

Double-stranded RNA-activated protein kinase regulates early innate immune responses during respiratory syncytial virus infection. PubMed ID: 20038207

Protein kinase R is responsible for the phosphorylation of eIF2alpha in rotavirus infection. PubMed ID: 20631127

Role of PKR and Type I IFNs in viral control during primary and secondary infection. PubMed ID: 20585572

Protein kinase R is a novel mediator of CD40 signaling and plays a critical role in modulating immunoglobulin expression during respiratory syncytial virus infection. PubMed ID: 21994357

Novel insights in the interplay between inflammation and metabolic diseases: a role for the pathogen sensing kinase PKR. PubMed ID: 21300116

Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice. PubMed ID: 22948222

Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense. PubMed ID: 22633459

Novel role of PKR in inflammasome activation and HMGB1 release. PubMed ID: 22801494

PKR regulates proliferation, differentiation and survival of murine hematopoietic stem/progenitor cells. PubMed ID: 23403623

The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages. PubMed ID: 23401008

Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation. PubMed ID: 23229543

Blocking the eIF2? kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory. PubMed ID: 23392680