Details for: Prnp

Gene ID: 19122

Symbol: Prnp

Ensembl ID: ENSMUSG00000079037

Description: prion protein

Associated with

Other Information

Genular Protein ID: 601784853

Symbol: PRIO_MOUSE

Name: Major prion protein

UniProtKB Accession Codes:

P04925

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CORUM 1 CTD 1 ChEBI 12 ChEMBL 1 DIP 1 DNASU 1 DisProt 1 EMBL 6 EMDB 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 74 Gene3D 1 GeneTree 1 Genevisible 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MINT 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 35 PDBsum 30 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2890436

Title: Distinct prion proteins in short and long scrapie incubation period mice.

PubMed ID: 2890436

DOI: 10.1016/0092-8674(87)90134-6

PubMed ID: 3462700

Title: Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent.

PubMed ID: 3462700

DOI: 10.1073/pnas.83.17.6372

PubMed ID: 9799790

Title: Complete genomic sequence and analysis of the prion protein gene region from three mammalian species.

PubMed ID: 9799790

DOI: 10.1101/gr.8.10.1022

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2894984

Title: Molecular pathology of scrapie-associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie.

PubMed ID: 2894984

DOI: 10.1111/j.1432-1033.1988.tb13883.x

PubMed ID: 3923361

Title: Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain.

PubMed ID: 3923361

DOI: 10.1038/315331a0

PubMed ID: 8035877

Title: Prion protein is necessary for normal synaptic function.

PubMed ID: 8035877

DOI: 10.1038/370295a0

PubMed ID: 8637886

Title: Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus.

PubMed ID: 8637886

DOI: 10.1073/pnas.93.6.2403

PubMed ID: 9837873

Title: Copper stimulates endocytosis of the prion protein.

PubMed ID: 9837873

DOI: 10.1074/jbc.273.50.33107

PubMed ID: 11032800

Title: Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo.

PubMed ID: 11032800

DOI: 10.1093/emboj/19.20.5324

PubMed ID: 11571277

Title: PrPC directly interacts with proteins involved in signaling pathways.

PubMed ID: 11571277

DOI: 10.1074/jbc.m103289200

PubMed ID: 11756421

Title: Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases.

PubMed ID: 11756421

DOI: 10.1074/jbc.m110197200

PubMed ID: 12732622

Title: Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.

PubMed ID: 12732622

DOI: 10.1074/jbc.m300394200

PubMed ID: 15161660

Title: Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice.

PubMed ID: 15161660

DOI: 10.1016/s0002-9440(10)63784-4

PubMed ID: 15007175

Title: Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.

PubMed ID: 15007175

DOI: 10.1073/pnas.0400131101

PubMed ID: 16923158

Title: Copper-dependent co-internalization of the prion protein and glypican-1.

PubMed ID: 16923158

DOI: 10.1111/j.1471-4159.2006.03981.x

PubMed ID: 16492732

Title: Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis.

PubMed ID: 16492732

DOI: 10.1073/pnas.0511290103

PubMed ID: 19524515

Title: Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration.

PubMed ID: 19524515

DOI: 10.1016/j.cell.2009.03.042

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19242475

Title: Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.

PubMed ID: 19242475

DOI: 10.1038/nature07761

PubMed ID: 19568430

Title: Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport.

PubMed ID: 19568430

DOI: 10.1371/journal.pone.0006115

PubMed ID: 19381258

Title: Early onset prion disease from octarepeat expansion correlates with copper or zinc binding properties.

PubMed ID: 19381258

DOI: 10.1371/journal.ppat.1000390

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20098419

Title: Axonal prion protein is required for peripheral myelin maintenance.

PubMed ID: 20098419

DOI: 10.1038/nn.2483

PubMed ID: 8700211

Title: NMR structure of the mouse prion protein domain PrP(121-321).

PubMed ID: 8700211

DOI: 10.1038/382180a0

PubMed ID: 9280298

Title: NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).

PubMed ID: 9280298

DOI: 10.1016/s0014-5793(97)00920-4

PubMed ID: 27501152

Title: The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6.

PubMed ID: 27501152

DOI: 10.1038/nature19312

Sequence Information:

  • Length: 254
  • Mass: 27977
  • Checksum: D5331E6321826CC0
  • Sequence:
    • MANLGYWLLA LFVTMWTDVG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGTWGQPH 
GGGWGQPHGG SWGQPHGGSW GQPHGGGWGQ GGGTHNQWNK PSKPKTNLKH VAGAAAAGAV 
VGGLGGYMLG SAMSRPMIHF GNDWEDRYYR ENMYRYPNQV YYRPVDQYSN QNNFVHDCVN 
ITIKQHTVTT TTKGENFTET DVKMMERVVE QMCVTQYQKE SQAYYDGRRS SSTVLFSSPP 
VILLISFLIF LIVG

Genular Protein ID: 1182619038

Symbol: Q3UG89_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UG89

Database IDs:

AGR 1 ARBA 19 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 InterPro 4 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 Pfam 2 RefSeq 1 RuleBase 1 SAM 3 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 254
  • Mass: 27963
  • Checksum: 85330163299E0A1B
  • Sequence:
    • MANLGYWLLA LFVTMWTDVG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGTWGQPH 
GGGWGQPHGG SWGQPHGGSW GQPHGGGWGQ GGGTHNQWNK PSKPKTNLKH VAGAAAAGAV 
VGGLGGYMLG SAMSRPMVHF GNDWEDRYYR ENMYRYPNQV YYRPVDQYSN QNNFVHDCVN 
ITIKQHTVTT TTKGENFTET DVKMMERVVE QMCVTQYQKE SQAYYDGRRS SSTVLFSSPP 
VILLISFLIF LIVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.