Genular: Defining Cellular Identity and Function

Details for: Prnp

Gene ID: 19122

Symbol: Prnp

Ensembl ID: ENSMUSG00000079037

Description: prion protein

Associated with

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
(R-MMU-9609523)
Protein localization
(R-MMU-9609507)
Activation of protein kinase activity
(GO:0032147)
Amyloid-beta binding
(GO:0001540)
Amyloid precursor protein metabolic process
(GO:0042982)
Aspartic-type endopeptidase inhibitor activity
(GO:0019828)
Atp-dependent protein binding
(GO:0043008)
Calcium-mediated signaling using intracellular calcium source
(GO:0035584)
Cell surface
(GO:0009986)
Cellular response to amyloid-beta
(GO:1904646)
Cellular response to copper ion
(GO:0071280)
Cellular response to xenobiotic stimulus
(GO:0071466)
Copper ion binding
(GO:0005507)
Cupric ion binding
(GO:1903135)
Cuprous ion binding
(GO:1903136)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Glycosaminoglycan binding
(GO:0005539)
Golgi apparatus
(GO:0005794)
Identical protein binding
(GO:0042802)
Inclusion body
(GO:0016234)
Intracellular copper ion homeostasis
(GO:0006878)
Intracellular membrane-bounded organelle
(GO:0043231)
Lamin binding
(GO:0005521)
Learning or memory
(GO:0007611)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Microtubule binding
(GO:0008017)
Mitochondrial outer membrane
(GO:0005741)
Molecular adaptor activity
(GO:0060090)
Molecular condensate scaffold activity
(GO:0140693)
Negative regulation of activated t cell proliferation
(GO:0046007)
Negative regulation of amyloid-beta formation
(GO:1902430)
Negative regulation of amyloid precursor protein catabolic process
(GO:1902992)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of calcineurin-nfat signaling cascade
(GO:0070885)
Negative regulation of dendritic spine maintenance
(GO:1902951)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of interleukin-2 production
(GO:0032703)
Negative regulation of interleukin-17 production
(GO:0032700)
Negative regulation of long-term synaptic potentiation
(GO:1900272)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of t cell receptor signaling pathway
(GO:0050860)
Negative regulation of type ii interferon production
(GO:0032689)
Neuron projection maintenance
(GO:1990535)
Nuclear membrane
(GO:0031965)
Nucleobase-containing compound metabolic process
(GO:0006139)
Plasma membrane
(GO:0005886)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Positive regulation of protein targeting to membrane
(GO:0090314)
Positive regulation of protein tyrosine kinase activity
(GO:0061098)
Postsynaptic density
(GO:0014069)
Protease binding
(GO:0002020)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein homooligomerization
(GO:0051260)
Protein sequestering activity
(GO:0140311)
Regulation of calcium ion import across plasma membrane
(GO:1905664)
Regulation of glutamate receptor signaling pathway
(GO:1900449)
Regulation of intracellular calcium activated chloride channel activity
(GO:1902938)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Regulation of potassium ion transmembrane transport
(GO:1901379)
Regulation of protein localization
(GO:0032880)
Response to amyloid-beta
(GO:1904645)
Response to cadmium ion
(GO:0046686)
Response to copper ion
(GO:0046688)
Response to oxidative stress
(GO:0006979)
Signaling receptor activity
(GO:0038023)
Terminal bouton
(GO:0043195)
Transmembrane transporter binding
(GO:0044325)
Tubulin binding
(GO:0015631)
Type 5 metabotropic glutamate receptor binding
(GO:0031802)

Other Information

Proteins

Major prion protein
Q3UG89_MOUSE

Genular Protein ID: 601784853

Symbol: PRIO_MOUSE

Name: Major prion protein

UniProtKB Accession Codes:

P04925

Database IDs:

Citations:

PubMed ID: 2890436

Title: Distinct prion proteins in short and long scrapie incubation period mice.

PubMed ID: 2890436

DOI: 10.1016/0092-8674(87)90134-6

PubMed ID: 3462700

Title: Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent.

PubMed ID: 3462700

DOI: 10.1073/pnas.83.17.6372

PubMed ID: 9799790

Title: Complete genomic sequence and analysis of the prion protein gene region from three mammalian species.

PubMed ID: 9799790

DOI: 10.1101/gr.8.10.1022

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2894984

Title: Molecular pathology of scrapie-associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie.

PubMed ID: 2894984

DOI: 10.1111/j.1432-1033.1988.tb13883.x

PubMed ID: 3923361

Title: Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain.

PubMed ID: 3923361

DOI: 10.1038/315331a0

PubMed ID: 8035877

Title: Prion protein is necessary for normal synaptic function.

PubMed ID: 8035877

DOI: 10.1038/370295a0

PubMed ID: 8637886

Title: Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus.

PubMed ID: 8637886

DOI: 10.1073/pnas.93.6.2403

PubMed ID: 9837873

Title: Copper stimulates endocytosis of the prion protein.

PubMed ID: 9837873

DOI: 10.1074/jbc.273.50.33107

PubMed ID: 11032800

Title: Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo.

PubMed ID: 11032800

DOI: 10.1093/emboj/19.20.5324

PubMed ID: 11571277

Title: PrPC directly interacts with proteins involved in signaling pathways.

PubMed ID: 11571277

DOI: 10.1074/jbc.m103289200

PubMed ID: 11756421

Title: Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases.

PubMed ID: 11756421

DOI: 10.1074/jbc.m110197200

PubMed ID: 12732622

Title: Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.

PubMed ID: 12732622

DOI: 10.1074/jbc.m300394200

PubMed ID: 15161660

Title: Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice.

PubMed ID: 15161660

DOI: 10.1016/s0002-9440(10)63784-4

PubMed ID: 15007175

Title: Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.

PubMed ID: 15007175

DOI: 10.1073/pnas.0400131101

PubMed ID: 16923158

Title: Copper-dependent co-internalization of the prion protein and glypican-1.

PubMed ID: 16923158

DOI: 10.1111/j.1471-4159.2006.03981.x

PubMed ID: 16492732

Title: Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis.

PubMed ID: 16492732

DOI: 10.1073/pnas.0511290103

PubMed ID: 19524515

Title: Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration.

PubMed ID: 19524515

DOI: 10.1016/j.cell.2009.03.042

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19242475

Title: Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.

PubMed ID: 19242475

DOI: 10.1038/nature07761

PubMed ID: 19568430

Title: Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport.

PubMed ID: 19568430

DOI: 10.1371/journal.pone.0006115

PubMed ID: 19381258

Title: Early onset prion disease from octarepeat expansion correlates with copper or zinc binding properties.

PubMed ID: 19381258

DOI: 10.1371/journal.ppat.1000390

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20098419

Title: Axonal prion protein is required for peripheral myelin maintenance.

PubMed ID: 20098419

DOI: 10.1038/nn.2483

PubMed ID: 8700211

Title: NMR structure of the mouse prion protein domain PrP(121-321).

PubMed ID: 8700211

DOI: 10.1038/382180a0

PubMed ID: 9280298

Title: NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).

PubMed ID: 9280298

DOI: 10.1016/s0014-5793(97)00920-4

PubMed ID: 27501152

Title: The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6.

PubMed ID: 27501152

DOI: 10.1038/nature19312

Sequence Information:

Length: 254
Mass: 27977
Checksum: D5331E6321826CC0
Sequence:

MANLGYWLLA LFVTMWTDVG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGTWGQPH 
GGGWGQPHGG SWGQPHGGSW GQPHGGGWGQ GGGTHNQWNK PSKPKTNLKH VAGAAAAGAV 
VGGLGGYMLG SAMSRPMIHF GNDWEDRYYR ENMYRYPNQV YYRPVDQYSN QNNFVHDCVN 
ITIKQHTVTT TTKGENFTET DVKMMERVVE QMCVTQYQKE SQAYYDGRRS SSTVLFSSPP 
VILLISFLIF LIVG

Genular Protein ID: 1182619038

Symbol: Q3UG89_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UG89

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 254
Mass: 27963
Checksum: 85330163299E0A1B
Sequence:

MANLGYWLLA LFVTMWTDVG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGTWGQPH 
GGGWGQPHGG SWGQPHGGSW GQPHGGGWGQ GGGTHNQWNK PSKPKTNLKH VAGAAAAGAV 
VGGLGGYMLG SAMSRPMVHF GNDWEDRYYR ENMYRYPNQV YYRPVDQYSN QNNFVHDCVN 
ITIKQHTVTT TTKGENFTET DVKMMERVVE QMCVTQYQKE SQAYYDGRRS SSTVLFSSPP 
VILLISFLIF LIVG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prnp

Associated with

Other Information

Distinct prion proteins in short and long scrapie incubation period mice. PubMed ID: 2890436

Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent. PubMed ID: 3462700

Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. PubMed ID: 9799790

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular pathology of scrapie-associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie. PubMed ID: 2894984

Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain. PubMed ID: 3923361

Prion protein is necessary for normal synaptic function. PubMed ID: 8035877

Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus. PubMed ID: 8637886

Copper stimulates endocytosis of the prion protein. PubMed ID: 9837873

Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo. PubMed ID: 11032800

PrPC directly interacts with proteins involved in signaling pathways. PubMed ID: 11571277

Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases. PubMed ID: 11756421

Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate. PubMed ID: 12732622

Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice. PubMed ID: 15161660

Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions. PubMed ID: 15007175

Copper-dependent co-internalization of the prion protein and glypican-1. PubMed ID: 16923158

Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. PubMed ID: 16492732

Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration. PubMed ID: 19524515

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. PubMed ID: 19242475

Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport. PubMed ID: 19568430

Early onset prion disease from octarepeat expansion correlates with copper or zinc binding properties. PubMed ID: 19381258

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Axonal prion protein is required for peripheral myelin maintenance. PubMed ID: 20098419

NMR structure of the mouse prion protein domain PrP(121-321). PubMed ID: 8700211

NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231). PubMed ID: 9280298

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. PubMed ID: 27501152

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073