Details for: Prox1

Gene ID: 19130

Symbol: Prox1

Ensembl ID: ENSMUSG00000010175

Description: prospero homeobox 1

Associated with

  • Acinar cell differentiation
    (GO:0090425)
  • Aorta smooth muscle tissue morphogenesis
    (GO:0060414)
  • Atrial cardiac muscle tissue morphogenesis
    (GO:0055009)
  • Blood vessel endothelial cell differentiation
    (GO:0060837)
  • Branching involved in pancreas morphogenesis
    (GO:0061114)
  • Cell population proliferation
    (GO:0008283)
  • Cerebellar granule cell differentiation
    (GO:0021707)
  • Circadian rhythm
    (GO:0007623)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Dentate gyrus development
    (GO:0021542)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Dna binding domain binding
    (GO:0050692)
  • Embryonic retina morphogenesis in camera-type eye
    (GO:0060059)
  • Endocardium formation
    (GO:0060214)
  • Epithelial cell migration
    (GO:0010631)
  • Hepatocyte cell migration
    (GO:0002194)
  • Hepatocyte differentiation
    (GO:0070365)
  • Hepatocyte proliferation
    (GO:0072574)
  • Inner ear development
    (GO:0048839)
  • Lbd domain binding
    (GO:0050693)
  • Lens fiber cell morphogenesis
    (GO:0070309)
  • Lens morphogenesis in camera-type eye
    (GO:0002089)
  • Lens placode formation involved in camera-type eye formation
    (GO:0046619)
  • Lymphangiogenesis
    (GO:0001946)
  • Lymphatic endothelial cell differentiation
    (GO:0060836)
  • Lymphatic endothelial cell fate commitment
    (GO:0060838)
  • Lymph vessel development
    (GO:0001945)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of bile acid biosynthetic process
    (GO:0070858)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of neuroblast proliferation
    (GO:0007406)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of viral genome replication
    (GO:0045071)
  • Neuroblast proliferation
    (GO:0007405)
  • Neuronal stem cell population maintenance
    (GO:0097150)
  • Neuron fate determination
    (GO:0048664)
  • Nuclear receptor binding
    (GO:0016922)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell cycle
    (GO:0045787)
  • Positive regulation of cell cycle checkpoint
    (GO:1901978)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cyclin-dependent protein serine/threonine kinase activity
    (GO:0045737)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of forebrain neuron differentiation
    (GO:2000979)
  • Positive regulation of heart growth
    (GO:0060421)
  • Positive regulation of neural precursor cell proliferation
    (GO:2000179)
  • Positive regulation of sarcomere organization
    (GO:0060298)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of circadian rhythm
    (GO:0042752)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rhythmic process
    (GO:0048511)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal muscle thin filament assembly
    (GO:0030240)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Venous blood vessel morphogenesis
    (GO:0048845)
  • Ventricular cardiac muscle tissue morphogenesis
    (GO:0055010)
  • Ventricular cardiac myofibril assembly
    (GO:0055005)
  • Ventricular septum morphogenesis
    (GO:0060412)

Other Information

Genular Protein ID: 4158895583

Symbol: PROX1_MOUSE

Name: Prospero homeobox protein 1

UniProtKB Accession Codes:

P48437 O88478 Q3UPV1 Q543D8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 4 Ensembl 3 GO 69 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9703987

Title: Characterization of the mouse Prox1 gene.

PubMed ID: 9703987

DOI: 10.1006/bbrc.1998.8989

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7908825

Title: Prox 1, a prospero-related homeobox gene expressed during mouse development.

PubMed ID: 7908825

DOI: 10.1016/0925-4773(93)90012-m

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18630941

Title: Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.

PubMed ID: 18630941

DOI: 10.1021/pr800223m

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22733308

Title: Transcription factor PROX1: its role in development and cancer.

PubMed ID: 22733308

DOI: 10.1007/s10555-012-9390-8

PubMed ID: 23723244

Title: Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors alpha- and gamma-mediated transactivation.

PubMed ID: 23723244

DOI: 10.1093/nar/gkt447

PubMed ID: 28179430

Title: Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

PubMed ID: 28179430

DOI: 10.1161/circresaha.116.308825

Sequence Information:

  • Length: 737
  • Mass: 83126
  • Checksum: 834DF6963FF5C9B5
  • Sequence:
    • MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS EQDVEYSVVQ 
HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN MNKNGGTEPS FQASGLSSTG 
SEVHQEDICS NSSRDSPPEC LSPFGRPTMS QFDVDRLCDE HLRAKRARVE NIIRGMSHSP 
SVALRGNENE REMAPQSVSP RESYRENKRK QKLPQQQQQS FQQLVSARKE QKREERRQLK 
QQLEDMQKQL RQLQEKFYQV YDSTDSENDE DGDLSEDSMR SEILDARAQD SVGRSDNEMC 
ELDPGQFIDR ARALIREQEM AENKPKREGS NKERDHGPNS LQPEGKHLAE TLKQELNTAM 
SQVVDTVVKV FSAKPSRQVP QVFPPLQIPQ ARFAVNGENH NFHTANQRLQ CFGDVIIPNP 
LDTFGSVQMP SSTDQTEALP LVVRKNSSEQ SASGPATGGH HQPLHQSPLS ATAGFTTPSF 
RHPFPLPLMA YPFQSPLGAP SGSFSGKDRA SPESLDLTRD TTSLRTKMSS HHLSHHPCSP 
AHPPSTAEGL SLSLIKSECG DLQDMSDISP YSGSAMQEGL SPNHLKKAKL MFFYTRYPSS 
NMLKTYFSDV KFNRCITSQL IKWFSNFREF YYIQMEKYAR QAINDGVTST EELSITRDCE 
LYRALNMHYN KANDFEVPER FLEVAQITLR EFFNAIIAGK DVDPSWKKAI YKVICKLDSE 
VPEIFKSPNC LQELLHE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.