Genular: Defining Cellular Identity and Function

Details for: Lgmn

Gene ID: 19141

Symbol: Lgmn

Ensembl ID: ENSMUSG00000021190

Description: legumain

Associated with

Adaptive immune system
(R-MMU-1280218)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Mhc class ii antigen presentation
(R-MMU-2132295)
Toll-like receptor cascades
(R-MMU-168898)
Trafficking and processing of endosomal tlr
(R-MMU-1679131)
Activation of cysteine-type endopeptidase activity
(GO:0097202)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Apical part of cell
(GO:0045177)
Associative learning
(GO:0008306)
Cellular response to amyloid-beta
(GO:1904646)
Cellular response to calcium ion
(GO:0071277)
Cellular response to hepatocyte growth factor stimulus
(GO:0035729)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasm
(GO:0005737)
Dendritic spine organization
(GO:0097061)
Endopeptidase activator activity
(GO:0061133)
Extracellular region
(GO:0005576)
Hydrolase activity
(GO:0016787)
Late endosome
(GO:0005770)
Lysosomal lumen
(GO:0043202)
Lysosome
(GO:0005764)
Memory
(GO:0007613)
Negative regulation of erbb signaling pathway
(GO:1901185)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of multicellular organism growth
(GO:0040015)
Negative regulation of neuron apoptotic process
(GO:0043524)
Peptidase activity
(GO:0008233)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell chemotaxis
(GO:2001028)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Positive regulation of mitotic cell cycle
(GO:0045931)
Positive regulation of monocyte chemotaxis
(GO:0090026)
Protein maturation
(GO:0051604)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Receptor catabolic process
(GO:0032801)
Renal system process
(GO:0003014)
Response to acidic ph
(GO:0010447)
Self proteolysis
(GO:0097264)
Vacuolar protein processing
(GO:0006624)

Other Information

Proteins

Protease, cysteine 1
Q3UE99_MOUSE

Genular Protein ID: 2542040110

Symbol: LGMN_MOUSE

Name: Protease, cysteine 1

UniProtKB Accession Codes:

O89017

Database IDs:

Citations:

PubMed ID: 9742219

Title: Cloning and expression of mouse legumain, a lysosomal endopeptidase.

PubMed ID: 9742219

DOI: 10.1042/bj3350111

PubMed ID: 9821970

Title: Autocatalytic activation of human legumain at aspartic acid residues.

PubMed ID: 9821970

DOI: 10.1016/s0014-5793(98)01281-2

PubMed ID: 9891971

Title: Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.

PubMed ID: 9891971

DOI: 10.1016/s0014-5793(98)01574-9

PubMed ID: 17350006

Title: Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells.

PubMed ID: 17350006

DOI: 10.1016/j.febslet.2007.02.064

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21292981

Title: Asparagine endopeptidase is required for normal kidney physiology and homeostasis.

PubMed ID: 21292981

DOI: 10.1096/fj.10-172312

PubMed ID: 24407422

Title: Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.

PubMed ID: 24407422

DOI: 10.1038/cr.2014.4

PubMed ID: 37347855

Title: Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells.

PubMed ID: 37347855

DOI: 10.1126/science.adg8802

Sequence Information:

Length: 435
Mass: 49373
Checksum: F956B9E10098013D
Sequence:

MTWRVAVLLS LVLGAGAVPV GVDDPEDGGK HWVVIVAGSN GWYNYRHQAD ACHAYQIIHR 
NGIPDEQIIV MMYDDIANSE ENPTPGVVIN RPNGTDVYKG VLKDYTGEDV TPENFLAVLR 
GDAEAVKGKG SGKVLKSGPR DHVFIYFTDH GATGILVFPN DDLHVKDLNK TIRYMYEHKM 
YQKMVFYIEA CESGSMMNHL PDDINVYATT AANPKESSYA CYYDEERGTY LGDWYSVNWM 
EDSDVEDLTK ETLHKQYHLV KSHTNTSHVM QYGNKSISTM KVMQFQGMKH RASSPISLPP 
VTHLDLTPSP DVPLTILKRK LLRTNDVKES QNLIGQIQQF LDARHVIEKS VHKIVSLLAG 
FGETAERHLS ERTMLTAHDC YQEAVTHFRT HCFNWHSVTY EHALRYLYVL ANLCEAPYPI 
DRIEMAMDKV CLSHY

Genular Protein ID: 3256921499

Symbol: Q3UE99_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UE99

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 243
Mass: 27229
Checksum: 7658BCE5DA07F125
Sequence:

MTWRVAVLLS LVLGAGAVPV GVDDPEDGGK HWVVIVAGSN GWYNYRHQAD ACHAYQIIHR 
NGIPDEQIIV MMYDDIANSE ENPTPGVVIN RPNGTDVYKG VLKDYTGEDV TPENFLAVLR 
GDAEAVKGKG SGKVLKSGPR DHVFIYFTDH GATGILVFPN DDLHVKDLNK TIRYMYEHKM 
YQKMVFYIEA CESGSMMNHL PDDINVYATT AANPKESSYA CYYDEERGTY LGDWYSVNWM 
EDS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lgmn

Associated with

Other Information

Cloning and expression of mouse legumain, a lysosomal endopeptidase. PubMed ID: 9742219

Autocatalytic activation of human legumain at aspartic acid residues. PubMed ID: 9821970

Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases. PubMed ID: 9891971

Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells. PubMed ID: 17350006

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Asparagine endopeptidase is required for normal kidney physiology and homeostasis. PubMed ID: 21292981

Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. PubMed ID: 24407422

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells. PubMed ID: 37347855

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073