Genular: Defining Cellular Identity and Function

Details for: Psmb10

Gene ID: 19171

Symbol: Psmb10

Ensembl ID: ENSMUSG00000031897

Description: proteasome (prosome, macropain) subunit, beta type 10

Associated with

Abc-family proteins mediated transport
(R-MMU-382556)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176814)
Activation of nf-kappab in b cells
(R-MMU-1169091)
Adaptive immune system
(R-MMU-1280218)
Antigen processing-cross presentation
(R-MMU-1236975)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-MMU-174178)
Assembly of the pre-replicative complex
(R-MMU-68867)
Asymmetric localization of pcp proteins
(R-MMU-4608870)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-MMU-450408)
Autodegradation of cdh1 by cdh1:apc/c
(R-MMU-174084)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Cellular response to hypoxia
(R-MMU-1234174)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cross-presentation of soluble exogenous antigens (endosomes)
(R-MMU-1236978)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Cytokine signaling in immune system
(R-MMU-1280215)
Dectin-1 mediated noncanonical nf-kb signaling
(R-MMU-5607761)
Degradation of axin
(R-MMU-4641257)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Degradation of dvl
(R-MMU-4641258)
Degradation of gli1 by the proteasome
(R-MMU-5610780)
Deubiquitination
(R-MMU-5688426)
Dna replication
(R-MMU-69306)
Dna replication pre-initiation
(R-MMU-69002)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Downstream tcr signaling
(R-MMU-202424)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
G1/s dna damage checkpoints
(R-MMU-69615)
G1/s transition
(R-MMU-69206)
G2/m checkpoints
(R-MMU-69481)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gli3 is processed to gli3r by the proteasome
(R-MMU-5610785)
Hedgehog 'off' state
(R-MMU-5610787)
Hedgehog 'on' state
(R-MMU-5632684)
Hedgehog ligand biogenesis
(R-MMU-5358346)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Intracellular signaling by second messengers
(R-MMU-9006925)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk6/mapk4 signaling
(R-MMU-5687128)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Metabolism of polyamines
(R-MMU-351202)
Metabolism of proteins
(R-MMU-392499)
Metabolism of rna
(R-MMU-8953854)
Mitotic anaphase
(R-MMU-68882)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase and anaphase
(R-MMU-2555396)
M phase
(R-MMU-68886)
Neddylation
(R-MMU-8951664)
Nik-->noncanonical nf-kb signaling
(R-MMU-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-MMU-1234176)
P53-dependent g1/s dna damage checkpoint
(R-MMU-69580)
P53-independent g1/s dna damage checkpoint
(R-MMU-69613)
Pcp/ce pathway
(R-MMU-4086400)
Pip3 activates akt signaling
(R-MMU-1257604)
Post-translational protein modification
(R-MMU-597592)
Pten regulation
(R-MMU-6807070)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-MMU-450531)
Regulation of ornithine decarboxylase (odc)
(R-MMU-350562)
Regulation of ras by gaps
(R-MMU-5658442)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by interleukins
(R-MMU-449147)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Tcr signaling
(R-MMU-202403)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Transcriptional regulation by runx1
(R-MMU-8878171)
Transcriptional regulation by runx2
(R-MMU-8878166)
Transcriptional regulation by runx3
(R-MMU-8878159)
Transport of small molecules
(R-MMU-382551)
Ub-specific processing proteases
(R-MMU-5689880)
Ubiquitin-dependent degradation of cyclin d
(R-MMU-75815)
Uch proteinases
(R-MMU-5689603)

Other Information

Proteins

Proteasome subunit beta type-10

Genular Protein ID: 3882188798

Symbol: PSB10_MOUSE

Name: Proteasome subunit beta type-10

UniProtKB Accession Codes:

O35955 O08687 Q99KC5

Database IDs:

Citations:

PubMed ID: 9367687

Title: DNA sequence, chromosomal localization, and tissue expression of the mouse proteasome subunit lmp10 (Psmb10) gene.

PubMed ID: 9367687

DOI: 10.1006/geno.1997.4977

PubMed ID: 9300697

Title: The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter.

PubMed ID: 9300697

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10413086

Title: Mutational analysis of subunit i beta2 (MECL-1) demonstrates conservation of cleavage specificity between yeast and mammalian proteasomes.

PubMed ID: 10413086

DOI: 10.1016/s0014-5793(99)00768-1

PubMed ID: 15907481

Title: IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.

PubMed ID: 15907481

DOI: 10.1016/j.febslet.2005.04.012

PubMed ID: 16709825

Title: An altered T cell repertoire in MECL-1-deficient mice.

PubMed ID: 16709825

DOI: 10.4049/jimmunol.176.11.6665

PubMed ID: 16857966

Title: Mapping the murine cardiac 26S proteasome complexes.

PubMed ID: 16857966

DOI: 10.1161/01.res.0000237386.98506.f7

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23706739

Title: Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.

PubMed ID: 23706739

DOI: 10.1016/j.cell.2013.04.032

PubMed ID: 22341445

Title: Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.

PubMed ID: 22341445

DOI: 10.1016/j.cell.2011.12.030

Sequence Information:

Length: 273
Mass: 29063
Checksum: 9A1AAE55888FA905
Sequence:

MLKQAVEPTG GFSFENCQRN ASLEHVLPGL RVPHARKTGT TIAGLVFRDG VILGADTRAT 
NDSVVADKSC EKIHFIAPKI YCCGAGVAAD TEMTTRMAAS KMELHALSTG REPRVATVTR 
ILRQTLFRYQ GHVGASLVVG GVDLNGPQLY EVHPHGSYSR LPFTALGSGQ GAAVALLEDR 
FQPNMTLEAA QELLVEAITA GILSDLGSGG NVDACVITAG GAKLQRALST PTEPVQRAGR 
YRFAPGTTPV LTREVRPLTL ELLEETVQAM EVE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Psmb10

Associated with

Other Information

DNA sequence, chromosomal localization, and tissue expression of the mouse proteasome subunit lmp10 (Psmb10) gene. PubMed ID: 9367687

The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter. PubMed ID: 9300697

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mutational analysis of subunit i beta2 (MECL-1) demonstrates conservation of cleavage specificity between yeast and mammalian proteasomes. PubMed ID: 10413086

IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome. PubMed ID: 15907481

An altered T cell repertoire in MECL-1-deficient mice. PubMed ID: 16709825

Mapping the murine cardiac 26S proteasome complexes. PubMed ID: 16857966

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. PubMed ID: 23706739

Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity. PubMed ID: 22341445