Genular: Defining Cellular Identity and Function

Details for: Psmb4

Gene ID: 19172

Symbol: Psmb4

Ensembl ID: ENSMUSG00000005779

Description: proteasome (prosome, macropain) subunit, beta type 4

Associated with

Abc-family proteins mediated transport
(R-MMU-382556)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176814)
Activation of nf-kappab in b cells
(R-MMU-1169091)
Adaptive immune system
(R-MMU-1280218)
Antigen processing-cross presentation
(R-MMU-1236975)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-MMU-174178)
Assembly of the pre-replicative complex
(R-MMU-68867)
Asymmetric localization of pcp proteins
(R-MMU-4608870)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-MMU-450408)
Autodegradation of cdh1 by cdh1:apc/c
(R-MMU-174084)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Cellular response to hypoxia
(R-MMU-1234174)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cross-presentation of soluble exogenous antigens (endosomes)
(R-MMU-1236978)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Cytokine signaling in immune system
(R-MMU-1280215)
Dectin-1 mediated noncanonical nf-kb signaling
(R-MMU-5607761)
Degradation of axin
(R-MMU-4641257)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Degradation of dvl
(R-MMU-4641258)
Degradation of gli1 by the proteasome
(R-MMU-5610780)
Deubiquitination
(R-MMU-5688426)
Dna replication
(R-MMU-69306)
Dna replication pre-initiation
(R-MMU-69002)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Downstream tcr signaling
(R-MMU-202424)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
G1/s dna damage checkpoints
(R-MMU-69615)
G1/s transition
(R-MMU-69206)
G2/m checkpoints
(R-MMU-69481)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gli3 is processed to gli3r by the proteasome
(R-MMU-5610785)
Hedgehog 'off' state
(R-MMU-5610787)
Hedgehog 'on' state
(R-MMU-5632684)
Hedgehog ligand biogenesis
(R-MMU-5358346)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Intracellular signaling by second messengers
(R-MMU-9006925)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk6/mapk4 signaling
(R-MMU-5687128)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Metabolism of polyamines
(R-MMU-351202)
Metabolism of proteins
(R-MMU-392499)
Metabolism of rna
(R-MMU-8953854)
Mitotic anaphase
(R-MMU-68882)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase and anaphase
(R-MMU-2555396)
M phase
(R-MMU-68886)
Neddylation
(R-MMU-8951664)
Nik-->noncanonical nf-kb signaling
(R-MMU-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-MMU-1234176)
P53-dependent g1/s dna damage checkpoint
(R-MMU-69580)
P53-independent g1/s dna damage checkpoint
(R-MMU-69613)
Pcp/ce pathway
(R-MMU-4086400)
Pip3 activates akt signaling
(R-MMU-1257604)
Post-translational protein modification
(R-MMU-597592)
Pten regulation
(R-MMU-6807070)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-MMU-450531)
Regulation of ornithine decarboxylase (odc)
(R-MMU-350562)
Regulation of ras by gaps
(R-MMU-5658442)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by interleukins
(R-MMU-449147)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Tcr signaling
(R-MMU-202403)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Transcriptional regulation by runx1
(R-MMU-8878171)
Transcriptional regulation by runx2
(R-MMU-8878166)
Transcriptional regulation by runx3
(R-MMU-8878159)
Transport of small molecules
(R-MMU-382551)
Ub-specific processing proteases
(R-MMU-5689880)
Ubiquitin-dependent degradation of cyclin d
(R-MMU-75815)
Uch proteinases
(R-MMU-5689603)

Other Information

Proteins

Proteasome subunit beta type-4

Genular Protein ID: 4049035479

Symbol: PSB4_MOUSE

Name: Proteasome subunit beta type-4

UniProtKB Accession Codes:

P99026 Q3THC0 Q3THI3 Q3U0S0 Q3UVQ4 Q62008 Q8BK27 Q91VV7

Database IDs:

Citations:

PubMed ID: 9197541

Title: Cloning and characterization of mouse Lmp3 cDNA, encoding a proteasome beta subunit.

PubMed ID: 9197541

DOI: 10.1016/s0378-1119(97)00003-6

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12874245

Title: The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling events.

PubMed ID: 12874245

DOI: 10.4049/jimmunol.171.3.1515

PubMed ID: 16581775

Title: Proteasome activator PA200 is required for normal spermatogenesis.

PubMed ID: 16581775

DOI: 10.1128/mcb.26.8.2999-3007.2006

PubMed ID: 16317774

Title: The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice.

PubMed ID: 16317774

DOI: 10.1002/pmic.200500218

PubMed ID: 16857966

Title: Mapping the murine cardiac 26S proteasome complexes.

PubMed ID: 16857966

DOI: 10.1161/01.res.0000237386.98506.f7

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22341445

Title: Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.

PubMed ID: 22341445

DOI: 10.1016/j.cell.2011.12.030

Sequence Information:

Length: 264
Mass: 29116
Checksum: 6B6B42B21DFA2B74
Sequence:

MEAFWESRAG HWAGGPAPGQ FYRIPATPSG LMDPASAPCE GPITRTQNPM VTGTSVLGVK 
FDGGVVIAAD MLGSYGSLAR FRNISRIMRV NDSTMLGASG DYADFQYLKQ VLGQMVIDEE 
LLGDGHSYSP RAIHSWLTRA MYSRRSKMNP LWNTMVIGGY ADGESFLGYV DMLGVAYEAP 
SLATGYGAYL AQPLLREVLE KQPVLSQTEA RELVERCMRV LYYRDARSYN RFQIATVTEK 
GVEIEGPLSA QTNWDIAHMI SGFE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Psmb4

Associated with

Other Information

Cloning and characterization of mouse Lmp3 cDNA, encoding a proteasome beta subunit. PubMed ID: 9197541

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling events. PubMed ID: 12874245

Proteasome activator PA200 is required for normal spermatogenesis. PubMed ID: 16581775

The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice. PubMed ID: 16317774

Mapping the murine cardiac 26S proteasome complexes. PubMed ID: 16857966

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity. PubMed ID: 22341445