Genular: Defining Cellular Identity and Function

Details for: Psme1

Gene ID: 19186

Symbol: Psme1

Ensembl ID: ENSMUSG00000022216

Description: proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

Associated with

Abc-family proteins mediated transport
(R-MMU-382556)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176814)
Activation of nf-kappab in b cells
(R-MMU-1169091)
Adaptive immune system
(R-MMU-1280218)
Antigen processing-cross presentation
(R-MMU-1236975)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-MMU-174178)
Assembly of the pre-replicative complex
(R-MMU-68867)
Asymmetric localization of pcp proteins
(R-MMU-4608870)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-MMU-450408)
Autodegradation of cdh1 by cdh1:apc/c
(R-MMU-174084)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Cellular response to hypoxia
(R-MMU-1234174)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cross-presentation of soluble exogenous antigens (endosomes)
(R-MMU-1236978)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Cytokine signaling in immune system
(R-MMU-1280215)
Dectin-1 mediated noncanonical nf-kb signaling
(R-MMU-5607761)
Degradation of axin
(R-MMU-4641257)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Degradation of dvl
(R-MMU-4641258)
Degradation of gli1 by the proteasome
(R-MMU-5610780)
Deubiquitination
(R-MMU-5688426)
Dna replication
(R-MMU-69306)
Dna replication pre-initiation
(R-MMU-69002)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Downstream tcr signaling
(R-MMU-202424)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
G1/s dna damage checkpoints
(R-MMU-69615)
G1/s transition
(R-MMU-69206)
G2/m checkpoints
(R-MMU-69481)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gli3 is processed to gli3r by the proteasome
(R-MMU-5610785)
Hedgehog 'off' state
(R-MMU-5610787)
Hedgehog 'on' state
(R-MMU-5632684)
Hedgehog ligand biogenesis
(R-MMU-5358346)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Intracellular signaling by second messengers
(R-MMU-9006925)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk6/mapk4 signaling
(R-MMU-5687128)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Metabolism of polyamines
(R-MMU-351202)
Metabolism of proteins
(R-MMU-392499)
Metabolism of rna
(R-MMU-8953854)
Mitotic anaphase
(R-MMU-68882)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase and anaphase
(R-MMU-2555396)
M phase
(R-MMU-68886)
Neddylation
(R-MMU-8951664)
Nik-->noncanonical nf-kb signaling
(R-MMU-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-MMU-1234176)
P53-dependent g1/s dna damage checkpoint
(R-MMU-69580)
P53-independent g1/s dna damage checkpoint
(R-MMU-69613)
Pcp/ce pathway
(R-MMU-4086400)
Pip3 activates akt signaling
(R-MMU-1257604)
Post-translational protein modification
(R-MMU-597592)
Pten regulation
(R-MMU-6807070)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-MMU-450531)
Regulation of ornithine decarboxylase (odc)
(R-MMU-350562)
Regulation of ras by gaps
(R-MMU-5658442)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by interleukins
(R-MMU-449147)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Tcr signaling
(R-MMU-202403)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Transcriptional regulation by runx1
(R-MMU-8878171)
Transcriptional regulation by runx2
(R-MMU-8878166)
Transcriptional regulation by runx3
(R-MMU-8878159)
Transport of small molecules
(R-MMU-382551)
Ub-specific processing proteases
(R-MMU-5689880)
Ubiquitin-dependent degradation of cyclin d
(R-MMU-75815)
Uch proteinases
(R-MMU-5689603)

Other Information

Proteins

Proteasome activator complex subunit 1

Genular Protein ID: 430154127

Symbol: PSME1_MOUSE

Name: Proteasome activator complex subunit 1

UniProtKB Accession Codes:

P97371 O35561 Q9D841

Database IDs:

Citations:

PubMed ID: 9218537

Title: PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes.

PubMed ID: 9218537

DOI: 10.1007/s002510050281

PubMed ID: 9162094

Title: Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki.

PubMed ID: 9162094

DOI: 10.1007/s002510050246

PubMed ID: 9590240

Title: Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes.

PubMed ID: 9590240

PubMed ID: 11345588

Title: Nucleotide sequence analysis of the ~35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes.

PubMed ID: 11345588

DOI: 10.1007/s002510100308

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 249
Mass: 28673
Checksum: 1E2CE09DA44A5346
Sequence:

MATLRVHPEA QAKVDVFRED LCSKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP 
LDIPVPDPVK EKEKEERKKQ QEKEEKEEKK KGDEDDKGPP CGPVNCNEKI VVLLQRLKPE 
IKDVTEQLNL VTTWLQLQIP RIEDGNNFGV AVQEKVFELM TNLHTKLEGF HTQISKYFSE 
RGDAVAKAAK QPHVGDYRQL VHELDEAEYQ EIRLMVMEIR NAYAVLYDII LKNFEKLKKP 
RGETKGMIY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Psme1

Associated with

Other Information

PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes. PubMed ID: 9218537

Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki. PubMed ID: 9162094

Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes. PubMed ID: 9590240

Nucleotide sequence analysis of the ~35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes. PubMed ID: 11345588

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072