Genular: Defining Cellular Identity and Function

Details for: Pten

Gene ID: 19211

Symbol: Pten

Ensembl ID: ENSMUSG00000013663

Description: phosphatase and tensin homolog

Associated with

Adaptive immune system
(R-MMU-1280218)
Deubiquitination
(R-MMU-5688426)
Downstream tcr signaling
(R-MMU-202424)
Immune system
(R-MMU-168256)
Inositol phosphate metabolism
(R-MMU-1483249)
Intracellular signaling by second messengers
(R-MMU-9006925)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of proteins
(R-MMU-392499)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Ovarian tumor domain proteases
(R-MMU-5689896)
Phospholipid metabolism
(R-MMU-1483257)
Pi metabolism
(R-MMU-1483255)
Pip3 activates akt signaling
(R-MMU-1257604)
Post-translational protein modification
(R-MMU-597592)
Pten regulation
(R-MMU-6807070)
Regulation of pten localization
(R-MMU-8948747)
Regulation of pten stability and activity
(R-MMU-8948751)
Signal transduction
(R-MMU-162582)
Synthesis of ip3 and ip4 in the cytosol
(R-MMU-1855204)
Synthesis of pips at the plasma membrane
(R-MMU-1660499)
Tcr signaling
(R-MMU-202403)
Ub-specific processing proteases
(R-MMU-5689880)
Adult behavior
(GO:0030534)
Anaphase-promoting complex binding
(GO:0010997)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
B cell proliferation
(GO:0042100)
Cell migration
(GO:0016477)
Cell population proliferation
(GO:0008283)
Cellular response to decreased oxygen levels
(GO:0036294)
Cellular response to insulin stimulus
(GO:0032869)
Central nervous system development
(GO:0007417)
Central nervous system myelin maintenance
(GO:0032286)
Central nervous system neuron axonogenesis
(GO:0021955)
Dentate gyrus development
(GO:0021542)
Dephosphorylation
(GO:0016311)
Enzyme binding
(GO:0019899)
Gene expression
(GO:0010467)
Heart development
(GO:0007507)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
(GO:0030351)
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
(GO:0051717)
Ionotropic glutamate receptor binding
(GO:0035255)
Learning or memory
(GO:0007611)
Lipid metabolic process
(GO:0006629)
Locomotory behavior
(GO:0007626)
Maternal behavior
(GO:0042711)
Memory
(GO:0007613)
Molecular function inhibitor activity
(GO:0140678)
Multicellular organismal response to stress
(GO:0033555)
Myelination
(GO:0042552)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of b cell proliferation
(GO:0030889)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of myelination
(GO:0031642)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of t cell proliferation
(GO:0042130)
Nervous system development
(GO:0007399)
Neuron-neuron synaptic transmission
(GO:0007270)
Neuron projection development
(GO:0031175)
Pdz domain binding
(GO:0030165)
Phosphatase activity
(GO:0016791)
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
(GO:0016314)
Phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
(GO:0051800)
Phosphatidylinositol-3-phosphate phosphatase activity
(GO:0004438)
Phosphatidylinositol phosphate phosphatase activity
(GO:0052866)
Phosphoprotein phosphatase activity
(GO:0004721)
Platelet-derived growth factor receptor binding
(GO:0005161)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein kinase binding
(GO:0019901)
Protein serine/threonine phosphatase activity
(GO:0004722)
Protein tyrosine kinase binding
(GO:1990782)
Protein tyrosine phosphatase activity
(GO:0004725)
Regulation of b cell apoptotic process
(GO:0002902)
Regulation of cellular component size
(GO:0032535)
Regulation of neuron projection development
(GO:0010975)
Regulation of protein stability
(GO:0031647)
Regulation of synaptic transmission, gabaergic
(GO:0032228)
Social behavior
(GO:0035176)
Spindle assembly involved in female meiosis
(GO:0007056)
Synapse assembly
(GO:0007416)
T cell proliferation
(GO:0042098)
Ubiquitin-specific protease binding
(GO:1990381)

Other Information

Proteins

Mutated in multiple advanced cancers 1
Q3UUT8_MOUSE

Genular Protein ID: 1058298000

Symbol: PTEN_MOUSE

Name: Mutated in multiple advanced cancers 1

UniProtKB Accession Codes:

O08586 Q3UFB0 Q542G1

Database IDs:

Citations:

PubMed ID: 9090379

Title: Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.

PubMed ID: 9090379

DOI: 10.1038/ng0497-356

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10339565

Title: PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.

PubMed ID: 10339565

DOI: 10.1073/pnas.96.11.6199

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19473982

Title: X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization.

PubMed ID: 19473982

DOI: 10.1074/jbc.c109.009522

PubMed ID: 19778506

Title: DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.

PubMed ID: 19778506

DOI: 10.1016/j.neuron.2009.08.008

PubMed ID: 20008297

Title: ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.

PubMed ID: 20008297

DOI: 10.1182/blood-2009-08-237222

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20940307

Title: Regulation of PTEN stability and activity by Plk3.

PubMed ID: 20940307

DOI: 10.1074/jbc.m110.166462

PubMed ID: 25801959

Title: Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity.

PubMed ID: 25801959

DOI: 10.1093/jmcb/mjv020

PubMed ID: 31492966

Title: The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation.

PubMed ID: 31492966

DOI: 10.1007/s00018-019-03280-5

PubMed ID: 33428810

Title: SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function.

PubMed ID: 33428810

DOI: 10.15252/emmm.202012632

Sequence Information:

Length: 403
Mass: 47152
Checksum: 75F97C3DD6843BA9
Sequence:

MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK 
HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA 
AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY 
LLKNHLDYRP VALLFHKMMF ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKFMY 
FEFPQPLPVC GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI 
DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT VEEPSNPEAS 
SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHSQI TKV

Genular Protein ID: 1965225996

Symbol: Q3UUT8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UUT8

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 128
Mass: 14550
Checksum: A1F0C8FEE45C71C0
Sequence:

NTFFIPGPEE TSEKVENGSL CDQEIDSICS IERADNDKEY LVLTLTKNDL DKANKDKANR 
YFSPNFKVKL YFTKTVEEPS NPEASSSTSV TPDVSDNEPD HYRYSDTTDS DPENEPFDED 
QHSQITKV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pten

Associated with

Other Information

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. PubMed ID: 9090379

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. PubMed ID: 10339565

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization. PubMed ID: 19473982

DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. PubMed ID: 19778506

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. PubMed ID: 20008297

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Regulation of PTEN stability and activity by Plk3. PubMed ID: 20940307

Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity. PubMed ID: 25801959

The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation. PubMed ID: 31492966

SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function. PubMed ID: 33428810

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073