Genular: Defining Cellular Identity and Function

Details for: Ptf1a

Gene ID: 19213

Symbol: Ptf1a

Ensembl ID: ENSMUSG00000026735

Description: pancreas specific transcription factor, 1a

Associated with

Amacrine cell differentiation
(GO:0035881)
Cell differentiation
(GO:0030154)
Cell fate commitment
(GO:0045165)
Cerebellum development
(GO:0021549)
Chromatin binding
(GO:0003682)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Developmental process
(GO:0032502)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
E-box binding
(GO:0070888)
Exocrine pancreas development
(GO:0031017)
Generation of neurons
(GO:0048699)
Hindbrain development
(GO:0030902)
Intracellular anatomical structure
(GO:0005622)
Multicellular organism development
(GO:0007275)
Nervous system development
(GO:0007399)
Neuron differentiation
(GO:0030182)
Neuron fate commitment
(GO:0048663)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pancreas development
(GO:0031016)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of neural retina development
(GO:0061074)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Retina layer formation
(GO:0010842)
Retina morphogenesis in camera-type eye
(GO:0060042)
Retinoic acid receptor signaling pathway
(GO:0048384)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Tissue development
(GO:0009888)
Transcription by rna polymerase ii
(GO:0006366)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

Pancreas transcription factor 1 subunit alpha

Genular Protein ID: 2929421809

Symbol: PTF1A_MOUSE

Name: Pancreas transcription factor 1 subunit alpha

UniProtKB Accession Codes:

Q9QX98 Q9QYF5 Q9QYF6

Database IDs:

Citations:

PubMed ID: 11318877

Title: p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos.

PubMed ID: 11318877

DOI: 10.1046/j.1365-2443.2001.00422.x

PubMed ID: 11562365

Title: The role of PTF1-P48 in pancreatic acinar gene expression.

PubMed ID: 11562365

DOI: 10.1074/jbc.m106264200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9851981

Title: The bHLH protein PTF1-p48 protein is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas.

PubMed ID: 9851981

DOI: 10.1101/gad.12.23.3752

PubMed ID: 12185368

Title: The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors.

PubMed ID: 12185368

DOI: 10.1038/ng959

PubMed ID: 15543146

Title: Mutations in PTF1A cause pancreatic and cerebellar agenesis.

PubMed ID: 15543146

DOI: 10.1038/ng1475

PubMed ID: 17075007

Title: Ptf1a determines horizontal and amacrine cell fates during mouse retinal development.

PubMed ID: 17075007

DOI: 10.1242/dev.02598

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 324
Mass: 35185
Checksum: E74109A84B5CFD79
Sequence:

MDAVLLEHFP GGLDTFPSPY FDEEDFFTDQ SSRDPLEDSD ELLGDEQAEV EFLSHQLHEY 
CYRDGACLLL QPAPSAAPHA LAPPPLGDPG EPEDNVSYCC DAGAPLAAFP YSPGSPPSCL 
AYPCAAVLSP GARLGGLNGA AAAAAARRRR RVRSEAELQQ LRQAANVRER RRMQSINDAF 
EGLRSHIPTL PYEKRLSKVD TLRLAIGYIN FLSELVQADL PLRGSGAGGC GGPGGSRHLG 
EDSPGNQAQK VIICHRGTRS PSPSDPDYGL PPLAGHSLSW TDEKQLKEQN IIRTAKVWTP 
EDPRKLNSKS FDNIENEPPF EFVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ptf1a

Associated with

Other Information

p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos. PubMed ID: 11318877

The role of PTF1-P48 in pancreatic acinar gene expression. PubMed ID: 11562365

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The bHLH protein PTF1-p48 protein is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. PubMed ID: 9851981

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. PubMed ID: 12185368

Mutations in PTF1A cause pancreatic and cerebellar agenesis. PubMed ID: 15543146

Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. PubMed ID: 17075007

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079