Details for: Ptger4

Gene ID: 19219

Symbol: Ptger4

Ensembl ID: ENSMUSG00000039942

Description: prostaglandin E receptor 4 (subtype EP4)

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-MMU-373076)
  • Eicosanoid ligand-binding receptors
    (R-MMU-391903)
  • G alpha (s) signalling events
    (R-MMU-418555)
  • Gpcr downstream signalling
    (R-MMU-388396)
  • Gpcr ligand binding
    (R-MMU-500792)
  • Prostanoid ligand receptors
    (R-MMU-391908)
  • Signaling by gpcr
    (R-MMU-372790)
  • Adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0007189)
  • Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
    (GO:0007188)
  • Bone development
    (GO:0060348)
  • Cellular response to mechanical stimulus
    (GO:0071260)
  • Cellular response to prostaglandin e stimulus
    (GO:0071380)
  • Chemokinesis
    (GO:0042466)
  • Ductus arteriosus closure
    (GO:0097070)
  • Erk1 and erk2 cascade
    (GO:0070371)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Inflammatory response
    (GO:0006954)
  • Interleukin-33 production
    (GO:0072639)
  • Jnk cascade
    (GO:0007254)
  • Membrane
    (GO:0016020)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of ductus arteriosus closure
    (GO:1904336)
  • Negative regulation of endothelin production
    (GO:1904471)
  • Negative regulation of eosinophil extravasation
    (GO:2000420)
  • Negative regulation of hydrogen peroxide metabolic process
    (GO:0010727)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of integrin activation
    (GO:0033624)
  • Negative regulation of interleukin-1 alpha production
    (GO:0032690)
  • Negative regulation of nitric-oxide synthase biosynthetic process
    (GO:0051771)
  • Negative regulation of peptide secretion
    (GO:0002792)
  • Negative regulation of small intestine smooth muscle contraction
    (GO:1904348)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Neuronal cell body
    (GO:0043025)
  • Neuron projection terminus
    (GO:0044306)
  • Nuclear membrane
    (GO:0031965)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of antral ovarian follicle growth
    (GO:2000388)
  • Positive regulation of bone resorption
    (GO:0045780)
  • Positive regulation of calcitonin secretion
    (GO:1904364)
  • Positive regulation of camp-mediated signaling
    (GO:0043950)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of chemokinesis
    (GO:1904367)
  • Positive regulation of circadian sleep/wake cycle, non-rem sleep
    (GO:0046010)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of hyaluronan biosynthetic process
    (GO:1900127)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of matrix metallopeptidase secretion
    (GO:1904466)
  • Positive regulation of mucus secretion
    (GO:0070257)
  • Positive regulation of neutrophil extravasation
    (GO:2000391)
  • Positive regulation of ossification
    (GO:0045778)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of ovarian follicle development
    (GO:2000386)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of protein secretion
    (GO:0050714)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of substance p secretion
    (GO:1904460)
  • Positive regulation of substance p secretion, neurotransmission
    (GO:1904496)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Positive regulation of urine volume
    (GO:0035810)
  • Positive regulation of wound healing
    (GO:0090303)
  • Prostaglandin e receptor activity
    (GO:0004957)
  • Prostaglandin receptor activity
    (GO:0004955)
  • Regulation of circadian sleep/wake cycle, wakefulness
    (GO:0010840)
  • Regulation of ossification
    (GO:0030278)
  • Regulation of stress fiber assembly
    (GO:0051492)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to nematode
    (GO:0009624)
  • Signal transduction
    (GO:0007165)
  • T-helper cell differentiation
    (GO:0042093)

Other Information

Genular Protein ID: 3636090185

Symbol: PE2R4_MOUSE

Name: Prostaglandin E2 receptor EP4 subtype

UniProtKB Accession Codes:

P32240

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DrugCentral 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 62 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 InParanoid 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 4 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8385118

Title: Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype.

PubMed ID: 8385118

DOI: 10.1016/s0021-9258(18)53022-2

PubMed ID: 8939885

Title: Prostanoid receptors of murine NIH 3T3 and RAW 264.7 cells. Structure and expression of the murine prostaglandin EP4 receptor gene.

PubMed ID: 8939885

DOI: 10.1074/jbc.271.47.29569

PubMed ID: 18270204

Title: Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation.

PubMed ID: 18270204

DOI: 10.1074/jbc.m709663200

Sequence Information:

  • Length: 513
  • Mass: 56158
  • Checksum: E29216087A561473
  • Sequence:
    • MAEVGGTIPR SNRELQRCVL LTTTIMSIPG VNASFSSTPE RLNSPVTIPA VMFIFGVVGN 
LVAIVVLCKS RKEQKETTFY TLVCGLAVTD LLGTLLVSPV TIATYMKGQW PGDQALCDYS 
TFILLFFGLS GLSIICAMSI ERYLAINHAY FYSHYVDKRL AGLTLFAIYA SNVLFCALPN 
MGLGRSERQY PGTWCFIDWT TNVTAYAAFS YMYAGFSSFL ILATVLCNVL VCGALLRMHR 
QFMRRTSLGT EQHHAAAAAA VASVACRGHA GASPALQRLS DFRRRRSFRR IAGAEIQMVI 
LLIATSLVVL ICSIPLVVRV FINQLYQPNV VKDISRNPDL QAIRIASVNP ILDPWIYILL 
RKTVLSKAIE KIKCLFCRIG GSGRDSSAQH CSESRRTSSA MSGHSRSFLA RELKEISSTS 
QTLLYLPDLT ESSLGGRNLL PGSHGMGLTQ ADTTSLRTLR ISETSDSSQG QDSESVLLVD 
EVSGSHREEP ASKGNSLQVT FPSETLKLSE KCI

Genular Protein ID: 2680661125

Symbol: Q91VE4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q91VE4

Database IDs:

AGR 1 ARBA 16 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HOGENOM 1 InterPro 5 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 4 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 488
  • Mass: 53417
  • Checksum: 0D4B48127283A5B2
  • Sequence:
    • MSIPGVNASF SSTPERLNSP VTIPAVMFIF GVVGNLVAIV VLCKSRKEQK ETTFYTLVCG 
LAVTDLLGTL LVSPVTIATY MKGQWPGDQA LCDYSTFILL FFGLSGLSII CAMSIERYLA 
INHAYFYSHY VDKRLAGLTL FAIYASNVLF CALPNMGLGR SERQYPGTWC FIDWTTNVTA 
YAAFSYMYAG FSSFLILATV LCNVLVCGAL LRMHRQFMRR TSLGTEQHHA AAAAAVASVA 
CRGHAGASPA LQRLSDFRRR RSFRRIAGAE IQMVILLIAT SLVVLICSIP LVVRVFINQL 
YQPNVVKDIS RNPDLQAIRI ASVNPILDPW IYILLRKTVL SKAIEKIKCL FCRIGGSGRD 
SSAQHCSESR RTSSAMSGHS RSFLARELKE ISSTSQTLLY LPDLTESSLG GRNLLPGSHG 
MGLTQADTTS LRTLRISETS DSSQGQDSES VLLVDEVSGS HREEPASKGN SLQVTFPSET 
LKLSEKCI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.