Genular: Defining Cellular Identity and Function

Details for: Ptgis

Gene ID: 19223

Symbol: Ptgis

Ensembl ID: ENSMUSG00000017969

Description: prostaglandin I2 (prostacyclin) synthase

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Bile acid and bile salt metabolism
(R-MMU-194068)
Biological oxidations
(R-MMU-211859)
Cytochrome p450 - arranged by substrate type
(R-MMU-211897)
Eicosanoids
(R-MMU-211979)
Endogenous sterols
(R-MMU-211976)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of steroids
(R-MMU-8957322)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Metabolism of water-soluble vitamins and cofactors
(R-MMU-196849)
Nicotinamide salvaging
(R-MMU-197264)
Nicotinate metabolism
(R-MMU-196807)
Phase i - functionalization of compounds
(R-MMU-211945)
Sterols are 12-hydroxylated by cyp8b1
(R-MMU-211994)
Synthesis of bile acids and bile salts
(R-MMU-192105)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(R-MMU-193368)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
(R-MMU-193775)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(R-MMU-193807)
Synthesis of prostaglandins (pg) and thromboxanes (tx)
(R-MMU-2162123)
Apoptotic signaling pathway
(GO:0097190)
Caveola
(GO:0005901)
Cellular response to hypoxia
(GO:0071456)
Cytoplasm
(GO:0005737)
Decidualization
(GO:0046697)
Embryo implantation
(GO:0007566)
Endoplasmic reticulum
(GO:0005783)
Extracellular space
(GO:0005615)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid metabolic process
(GO:0006631)
Heme binding
(GO:0020037)
Hydroperoxy icosatetraenoate dehydratase activity
(GO:0106256)
Icosanoid metabolic process
(GO:0006690)
Iron ion binding
(GO:0005506)
Isomerase activity
(GO:0016853)
Lipid metabolic process
(GO:0006629)
Lyase activity
(GO:0016829)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Monooxygenase activity
(GO:0004497)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of nitric oxide biosynthetic process
(GO:0045019)
Nucleus
(GO:0005634)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(GO:0016705)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of execution phase of apoptosis
(GO:1900119)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Prostaglandin-i synthase activity
(GO:0008116)
Prostaglandin biosynthetic process
(GO:0001516)
Prostaglandin metabolic process
(GO:0006693)
Response to hypoxia
(GO:0001666)

Other Information

Proteins

Prostacyclin synthase

Genular Protein ID: 1127259246

Symbol: PTGIS_MOUSE

Name: Prostacyclin synthase

UniProtKB Accession Codes:

O35074

Database IDs:

Citations:

PubMed ID: 9202154

Title: Inverse gene expression of prostacyclin and thromboxane synthases in resident and activated peritoneal macrophages.

PubMed ID: 9202154

DOI: 10.1016/s0014-5793(97)00516-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 501
Mass: 57047
Checksum: F018F85D3A1B0EBB
Sequence:

MSWAALLGLL AVLLLLLLLL SRRRARRPGE PPLDLGSIPW LGHALEFGRD AASFLTRMKE 
KHGDIFTVLV GGRYVTVLLD PHSYDTVVWE LRTRLDFHPY AIFLMERIFD LQLPNFNPSE 
EKARMKPTLM HRDLQALTEA MYTNLRTVLL GDSTEAGSGW QETGLLEFSY NALLSAGYLT 
LYGVEASPRT HESQAQDRVH SADVFHTFRQ LDLLLPKLAR GSLSAGDKDH ACSVKNRLWK 
LLSPARLASR ADRSSWLESY LRHLEEMGVS EEMQARALVL QLWATQGNMG PTAFWLLLFL 
LKNPEALAAV RAELKHTVWQ AEQPVSQMTT LPQKILDSMP VLDSVLNETL RLTAAPFITR 
EVMADLALPM ADGREFSLRR GDRLLLFPFL SPQKDPEIYT EPEVFKYNRF LNPDGSEKKD 
FYKDGKRLKN YNMPWGAGHN QCLGKSYAIN SIKQFVVLLL THFDLELGSE DTEVPEFDLS 
RYGFGLMQPE EDVPIRYRAR L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ptgis

Associated with

Other Information

Inverse gene expression of prostacyclin and thromboxane synthases in resident and activated peritoneal macrophages. PubMed ID: 9202154

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 9202154

PubMed ID: 16141072

PubMed ID: 15489334

PubMed ID: 21183079