Genular: Defining Cellular Identity and Function

Details for: Ptgs1

Gene ID: 19224

Symbol: Ptgs1

Ensembl ID: ENSMUSG00000047250

Description: prostaglandin-endoperoxide synthase 1

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Biological oxidations
(R-MMU-211859)
Cox reactions
(R-MMU-140180)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Phase i - functionalization of compounds
(R-MMU-211945)
Synthesis of prostaglandins (pg) and thromboxanes (tx)
(R-MMU-2162123)
Cyclooxygenase pathway
(GO:0019371)
Cytoplasm
(GO:0005737)
Dioxygenase activity
(GO:0051213)
Endoplasmic reticulum
(GO:0005783)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid metabolic process
(GO:0006631)
Golgi apparatus
(GO:0005794)
Heme binding
(GO:0020037)
Intracellular membrane-bounded organelle
(GO:0043231)
Keratinocyte differentiation
(GO:0030216)
Learning
(GO:0007612)
Lipid metabolic process
(GO:0006629)
Maintenance of blood-brain barrier
(GO:0035633)
Membrane
(GO:0016020)
Memory
(GO:0007613)
Metal ion binding
(GO:0046872)
Negative regulation of epinephrine secretion
(GO:0032811)
Negative regulation of norepinephrine secretion
(GO:0010700)
Neuron projection
(GO:0043005)
Nuclear envelope
(GO:0005635)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
(GO:0016702)
Peroxidase activity
(GO:0004601)
Photoreceptor outer segment
(GO:0001750)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of vasoconstriction
(GO:0045907)
Prostaglandin-endoperoxide synthase activity
(GO:0004666)
Prostaglandin biosynthetic process
(GO:0001516)
Prostaglandin metabolic process
(GO:0006693)
Regulation of blood pressure
(GO:0008217)
Regulation of cell population proliferation
(GO:0042127)
Response to oxidative stress
(GO:0006979)

Other Information

Proteins

Cyclooxygenase-1

Genular Protein ID: 1773717666

Symbol: PGH1_MOUSE

Name: Cyclooxygenase-1

UniProtKB Accession Codes:

P22437

Database IDs:

Citations:

PubMed ID: 2108169

Title: The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.

PubMed ID: 2108169

DOI: 10.1016/s0021-9258(19)34105-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10966456

Title: Cyclooxygenases: structural, cellular, and molecular biology.

PubMed ID: 10966456

DOI: 10.1146/annurev.biochem.69.1.145

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24605250

Title: Aspirin, cyclooxygenase inhibition and colorectal cancer.

PubMed ID: 24605250

DOI: 10.4292/wjgpt.v5.i1.40

Sequence Information:

Length: 602
Mass: 69042
Checksum: 634C0E602045C3A0
Sequence:

MSRRSLSLWF PLLLLLLLPP TPSVLLADPG VPSPVNPCCY YPCQNQGVCV RFGLDNYQCD 
CTRTGYSGPN CTIPEIWTWL RNSLRPSPSF THFLLTHGYW LWEFVNATFI REVLMRLVLT 
VRSNLIPSPP TYNSAHDYIS WESFSNVSYY TRILPSVPKD CPTPMGTKGK KQLPDVQLLA 
QQLLLRREFI PAPQGTNILF AFFAQHFTHQ FFKTSGKMGP GFTKALGHGV DLGHIYGDNL 
ERQYHLRLFK DGKLKYQVLD GEVYPPSVEQ ASVLMRYPPG VPPERQMAVG QEVFGLLPGL 
MLFSTIWLRE HNRVCDLLKE EHPTWDDEQL FQTTRLILIG ETIKIVIEEY VQHLSGYFLQ 
LKFDPELLFR AQFQYRNRIA MEFNHLYHWH PLMPNSFQVG SQEYSYEQFL FNTSMLVDYG 
VEALVDAFSR QRAGRIGGGR NFDYHVLHVA VDVIKESREM RLQPFNEYRK RFGLKPYTSF 
QELTGEKEMA AELEELYGDI DALEFYPGLL LEKCQPNSIF GESMIEMGAP FSLKGLLGNP 
ICSPEYWKPS TFGGDVGFNL VNTASLKKLV CLNTKTCPYV SFRVPDYPGD DGSVLVRRST 
EL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ptgs1

Associated with

Other Information

The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases. PubMed ID: 2108169

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cyclooxygenases: structural, cellular, and molecular biology. PubMed ID: 10966456