Genular: Defining Cellular Identity and Function

Details for: Ptgs2

Gene ID: 19225

Symbol: Ptgs2

Ensembl ID: ENSMUSG00000032487

Description: prostaglandin-endoperoxide synthase 2

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Biosynthesis of dha-derived spms
(R-MMU-9018677)
Biosynthesis of dpa-derived spms
(R-MMU-9018683)
Biosynthesis of dpan-3 spms
(R-MMU-9025094)
Biosynthesis of electrophilic ω-3 pufa oxo-derivatives
(R-MMU-9027604)
Biosynthesis of epa-derived spms
(R-MMU-9018679)
Biosynthesis of specialized proresolving mediators (spms)
(R-MMU-9018678)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Metabolism of water-soluble vitamins and cofactors
(R-MMU-196849)
Nicotinamide salvaging
(R-MMU-197264)
Nicotinate metabolism
(R-MMU-196807)
Synthesis of 15-eicosatetraenoic acid derivatives
(R-MMU-2142770)
Synthesis of prostaglandins (pg) and thromboxanes (tx)
(R-MMU-2162123)
Anagen
(GO:0042640)
Angiogenesis
(GO:0001525)
Bone mineralization
(GO:0030282)
Brown fat cell differentiation
(GO:0050873)
Caveola
(GO:0005901)
Cellular response to fluid shear stress
(GO:0071498)
Cellular response to non-ionic osmotic stress
(GO:0071471)
Cyclooxygenase pathway
(GO:0019371)
Cytoplasm
(GO:0005737)
Decidualization
(GO:0046697)
Dioxygenase activity
(GO:0051213)
Embryo implantation
(GO:0007566)
Endoplasmic reticulum
(GO:0005783)
Enzyme binding
(GO:0019899)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid metabolic process
(GO:0006631)
Heme binding
(GO:0020037)
Intracellular membrane-bounded organelle
(GO:0043231)
Keratinocyte differentiation
(GO:0030216)
Learning
(GO:0007612)
Lipid metabolic process
(GO:0006629)
Maintenance of blood-brain barrier
(GO:0035633)
Membrane
(GO:0016020)
Memory
(GO:0007613)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of calcium ion transport
(GO:0051926)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
(GO:1902219)
Negative regulation of smooth muscle contraction
(GO:0045986)
Negative regulation of synaptic transmission, dopaminergic
(GO:0032227)
Neuron projection
(GO:0043005)
Nuclear inner membrane
(GO:0005637)
Nuclear outer membrane
(GO:0005640)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
(GO:0016702)
Peroxidase activity
(GO:0004601)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of brown fat cell differentiation
(GO:0090336)
Positive regulation of cell migration involved in sprouting angiogenesis
(GO:0090050)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of fever generation
(GO:0031622)
Positive regulation of fibroblast growth factor production
(GO:0090271)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of platelet-derived growth factor production
(GO:0090362)
Positive regulation of prostaglandin biosynthetic process
(GO:0031394)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of synaptic plasticity
(GO:0031915)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Positive regulation of transforming growth factor beta production
(GO:0071636)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Positive regulation of vasoconstriction
(GO:0045907)
Prostaglandin-endoperoxide synthase activity
(GO:0004666)
Prostaglandin biosynthetic process
(GO:0001516)
Prostaglandin metabolic process
(GO:0006693)
Prostaglandin secretion
(GO:0032310)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of blood pressure
(GO:0008217)
Regulation of cell population proliferation
(GO:0042127)
Regulation of neuroinflammatory response
(GO:0150077)
Response to cytokine
(GO:0034097)
Response to lipopolysaccharide
(GO:0032496)
Response to nematode
(GO:0009624)
Response to oxidative stress
(GO:0006979)

Other Information

Proteins

Cyclooxygenase-2

Genular Protein ID: 4014448118

Symbol: PGH2_MOUSE

Name: Cyclooxygenase-2

UniProtKB Accession Codes:

Q05769 Q543K3

Database IDs:

Citations:

PubMed ID: 1712772

Title: TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue.

PubMed ID: 1712772

DOI: 10.1016/s0021-9258(18)98774-0

PubMed ID: 1339449

Title: Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.

PubMed ID: 1339449

DOI: 10.1016/s0021-9258(18)42840-2

PubMed ID: 1419907

Title: Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity.

PubMed ID: 1419907

PubMed ID: 1594589

Title: cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

PubMed ID: 1594589

DOI: 10.1073/pnas.89.11.4888

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 1744122

Title: A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

PubMed ID: 1744122

DOI: 10.1016/s0021-9258(18)54491-4

PubMed ID: 8482922

Title: The mouse macrophage activation-associated marker protein, p71/73, is an inducible prostaglandin endoperoxide synthase (cyclooxygenase).

PubMed ID: 8482922

DOI: 10.1002/jlb.53.4.411

PubMed ID: 8349699

Title: N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.

PubMed ID: 8349699

DOI: 10.1016/s0021-9258(17)46835-9

PubMed ID: 9545330

Title: Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy.

PubMed ID: 9545330

DOI: 10.1074/jbc.273.16.9886

PubMed ID: 12244105

Title: Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides.

PubMed ID: 12244105

DOI: 10.1074/jbc.m206788200

PubMed ID: 22465430

Title: Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice.

PubMed ID: 22465430

DOI: 10.1053/j.gastro.2012.03.037

PubMed ID: 22942274

Title: Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid.

PubMed ID: 22942274

DOI: 10.1074/jbc.m112.381202

PubMed ID: 29662056

Title: Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

PubMed ID: 29662056

DOI: 10.1038/s41467-018-03674-2

PubMed ID: 10966456

Title: Cyclooxygenases: structural, cellular, and molecular biology.

PubMed ID: 10966456

DOI: 10.1146/annurev.biochem.69.1.145

PubMed ID: 24605250

Title: Aspirin, cyclooxygenase inhibition and colorectal cancer.

PubMed ID: 24605250

DOI: 10.4292/wjgpt.v5.i1.40

PubMed ID: 8967954

Title: Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.

PubMed ID: 8967954

DOI: 10.1038/384644a0

PubMed ID: 10811226

Title: Structural insights into the stereochemistry of the cyclooxygenase reaction.

PubMed ID: 10811226

DOI: 10.1038/35011103

PubMed ID: 12925531

Title: A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385.

PubMed ID: 12925531

DOI: 10.1074/jbc.m305481200

PubMed ID: 20463020

Title: Structural basis of fatty acid substrate binding to cyclooxygenase-2.

PubMed ID: 20463020

DOI: 10.1074/jbc.m110.119867

PubMed ID: 20810665

Title: Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.

PubMed ID: 20810665

DOI: 10.1074/jbc.m110.162982

PubMed ID: 21467029

Title: Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer.

PubMed ID: 21467029

DOI: 10.1074/jbc.m111.231969

PubMed ID: 21489986

Title: The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.

PubMed ID: 21489986

DOI: 10.1074/jbc.m111.230367

Sequence Information:

Length: 604
Mass: 69013
Checksum: DFE1658295C92064
Sequence:

MLFRAVLLCA ALGLSQAANP CCSNPCQNRG ECMSTGFDQY KCDCTRTGFY GENCTTPEFL 
TRIKLLLKPT PNTVHYILTH FKGVWNIVNN IPFLRSLIMK YVLTSRSYLI DSPPTYNVHY 
GYKSWEAFSN LSYYTRALPP VADDCPTPMG VKGNKELPDS KEVLEKVLLR REFIPDPQGS 
NMMFAFFAQH FTHQFFKTDH KRGPGFTRGL GHGVDLNHIY GETLDRQHKL RLFKDGKLKY 
QVIGGEVYPP TVKDTQVEMI YPPHIPENLQ FAVGQEVFGL VPGLMMYATI WLREHNRVCD 
ILKQEHPEWG DEQLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE LLFNQQFQYQ 
NRIASEFNTL YHWHPLLPDT FNIEDQEYSF KQFLYNNSIL LEHGLTQFVE SFTRQIAGRV 
AGGRNVPIAV QAVAKASIDQ SREMKYQSLN EYRKRFSLKP YTSFEELTGE KEMAAELKAL 
YSDIDVMELY PALLVEKPRP DAIFGETMVE LGAPFSLKGL MGNPICSPQY WKPSTFGGEV 
GFKIINTASI QSLICNNVKG CPFTSFNVQD PQPTKTATIN ASASHSRLDD INPTVLIKRR 
STEL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ptgs2

Associated with

Other Information

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. PubMed ID: 1712772

Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. PubMed ID: 1339449

Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity. PubMed ID: 1419907

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. PubMed ID: 1594589

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. PubMed ID: 1744122

The mouse macrophage activation-associated marker protein, p71/73, is an inducible prostaglandin endoperoxide synthase (cyclooxygenase). PubMed ID: 8482922

N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum. PubMed ID: 8349699

Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy. PubMed ID: 9545330

Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. PubMed ID: 12244105

Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice. PubMed ID: 22465430

Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid. PubMed ID: 22942274

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. PubMed ID: 29662056

Cyclooxygenases: structural, cellular, and molecular biology. PubMed ID: 10966456

Aspirin, cyclooxygenase inhibition and colorectal cancer. PubMed ID: 24605250

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. PubMed ID: 8967954

Structural insights into the stereochemistry of the cyclooxygenase reaction. PubMed ID: 10811226

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. PubMed ID: 12925531

Structural basis of fatty acid substrate binding to cyclooxygenase-2. PubMed ID: 20463020

Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. PubMed ID: 20810665

Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer. PubMed ID: 21467029

The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. PubMed ID: 21489986