Genular: Defining Cellular Identity and Function

Details for: Twf1

Gene ID: 19230

Symbol: Twf1

Ensembl ID: ENSMUSG00000022451

Description: twinfilin actin binding protein 1

Associated with

Rhobtb2 gtpase cycle
(R-MMU-9013418)
Rhobtb gtpase cycle
(R-MMU-9706574)
Rho gtpase cycle
(R-MMU-9012999)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin filament
(GO:0005884)
Actin filament binding
(GO:0051015)
Actin filament depolymerization
(GO:0030042)
Actin monomer binding
(GO:0003785)
Atp binding
(GO:0005524)
Barbed-end actin filament capping
(GO:0051016)
Cell-cell junction
(GO:0005911)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Filopodium
(GO:0030175)
Myofibril
(GO:0030016)
Negative regulation of actin filament polymerization
(GO:0030837)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of neuron projection development
(GO:0010976)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of actin phosphorylation
(GO:0043538)
Regulation of lamellipodium assembly
(GO:0010591)
Ruffle membrane
(GO:0032587)
Sequestering of actin monomers
(GO:0042989)

Other Information

Proteins

Twinfilin-1

Genular Protein ID: 3825257932

Symbol: TWF1_MOUSE

Name: Twinfilin-1

UniProtKB Accession Codes:

Q91YR1 O09132 Q52L77 Q80X09

Database IDs:

Citations:

PubMed ID: 9249064

Title: Cloning and characterization of the mouse homolog of the human A6 gene.

PubMed ID: 9249064

DOI: 10.1016/s0378-1119(97)00073-5

PubMed ID: 12807912

Title: Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated.

PubMed ID: 12807912

DOI: 10.1074/jbc.m303642200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10669753

Title: Mouse A6/twinfilin is an actin monomer-binding protein that localizes to the regions of rapid actin dynamics.

PubMed ID: 10669753

DOI: 10.1128/mcb.20.5.1772-1783.2000

PubMed ID: 15282541

Title: Biological role and structural mechanism of twinfilin-capping protein interaction.

PubMed ID: 15282541

DOI: 10.1038/sj.emboj.7600310

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16511569

Title: Mammalian twinfilin sequesters ADP-G-actin and caps filament barbed ends: implications in motility.

PubMed ID: 16511569

DOI: 10.1038/sj.emboj.7601019

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 12207032

Title: Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin.

PubMed ID: 12207032

DOI: 10.1074/jbc.m208225200

PubMed ID: 19768801

Title: NMR solution structures of actin depolymerizing factor homology domains.

PubMed ID: 19768801

DOI: 10.1002/pro.248

Sequence Information:

Length: 350
Mass: 40079
Checksum: 643CBBA18D38D4E0
Sequence:

MSHQTGIQAS EDVKEIFARA RNGKYRLLKI SIENEQLVVG SCSPPSDSWE QDYDSFVLPL 
LEDKQPCYVL FRLDSQNAQG YEWIFIAWSP DHSHVRQKML YAATRATLKK EFGGGHIKDE 
VFGTVKEDVS LHGYKKYLLS QSSPAPLTAA EEELRQIKIN EVQTDVSVDT KHQTLQGVAF 
PISRDAFQAL EKLSKKQLNY VQLEIDIKNE TIILANTENT ELRDLPKRIP KDSARYHFFL 
YKHSHEGDYL ESVVFIYSMP GYTCSIRERM LYSSCKSPLL EIVERQLQMD VIRKIEIDNG 
DELTADFLYD EVHPKQHAHK QSFAKPKGPA GKRGIRRLIR GPAEAEATTD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Twf1

Associated with

Other Information

Cloning and characterization of the mouse homolog of the human A6 gene. PubMed ID: 9249064

Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated. PubMed ID: 12807912

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mouse A6/twinfilin is an actin monomer-binding protein that localizes to the regions of rapid actin dynamics. PubMed ID: 10669753

Biological role and structural mechanism of twinfilin-capping protein interaction. PubMed ID: 15282541

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Mammalian twinfilin sequesters ADP-G-actin and caps filament barbed ends: implications in motility. PubMed ID: 16511569

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin. PubMed ID: 12207032

NMR solution structures of actin depolymerizing factor homology domains. PubMed ID: 19768801