Genular: Defining Cellular Identity and Function

Details for: Ptpn1

Gene ID: 19246

Symbol: Ptpn1

Ensembl ID: ENSMUSG00000027540

Description: protein tyrosine phosphatase, non-receptor type 1

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Growth hormone receptor signaling
(R-MMU-982772)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Integrin signaling
(R-MMU-354192)
Interferon alpha/beta signaling
(R-MMU-909733)
Interferon signaling
(R-MMU-913531)
Negative regulation of met activity
(R-MMU-6807004)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet aggregation (plug formation)
(R-MMU-76009)
Ptk6 down-regulation
(R-MMU-8849472)
Regulation of ifna/ifnb signaling
(R-MMU-912694)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by met
(R-MMU-6806834)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by ptk6
(R-MMU-8848021)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Actin cytoskeleton organization
(GO:0030036)
Cytoplasm
(GO:0005737)
Cytoplasmic side of endoplasmic reticulum membrane
(GO:0098554)
Cytosol
(GO:0005829)
Dephosphorylation
(GO:0016311)
Early endosome
(GO:0005769)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Endosome lumen
(GO:0031904)
Enzyme binding
(GO:0019899)
Ephrin receptor binding
(GO:0046875)
Hydrolase activity
(GO:0016787)
Insulin receptor binding
(GO:0005158)
Insulin receptor recycling
(GO:0038020)
Insulin receptor signaling pathway
(GO:0008286)
Ire1-mediated unfolded protein response
(GO:0036498)
Membrane
(GO:0016020)
Mitochondrial crista
(GO:0030061)
Mitochondrial matrix
(GO:0005759)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902236)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of perk-mediated unfolded protein response
(GO:1903898)
Negative regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030948)
Non-membrane spanning protein tyrosine phosphatase activity
(GO:0004726)
Peptidyl-tyrosine dephosphorylation
(GO:0035335)
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
(GO:1990264)
Phosphatase activity
(GO:0016791)
Phosphoprotein phosphatase activity
(GO:0004721)
Plasma membrane
(GO:0005886)
Platelet-derived growth factor receptor-beta signaling pathway
(GO:0035791)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of protein tyrosine kinase activity
(GO:0061098)
Positive regulation of receptor catabolic process
(GO:2000646)
Protein-containing complex
(GO:0032991)
Protein dephosphorylation
(GO:0006470)
Protein kinase binding
(GO:0019901)
Protein phosphatase 2a binding
(GO:0051721)
Protein tyrosine phosphatase activity
(GO:0004725)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of endocytosis
(GO:0030100)
Regulation of hepatocyte growth factor receptor signaling pathway
(GO:1902202)
Regulation of insulin receptor signaling pathway
(GO:0046626)
Regulation of intracellular protein transport
(GO:0033157)
Regulation of signal transduction
(GO:0009966)
Response to endoplasmic reticulum stress
(GO:0034976)
Sorting endosome
(GO:0097443)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Tyrosine-protein phosphatase non-receptor type 1

Genular Protein ID: 3709671017

Symbol: PTN1_MOUSE

Name: Tyrosine-protein phosphatase non-receptor type 1

UniProtKB Accession Codes:

P35821 Q60840 Q62131 Q64498 Q99JS1

Database IDs:

Citations:

PubMed ID: 1932742

Title: Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification.

PubMed ID: 1932742

PubMed ID: 1378268

Title: The cDNA cloning, nucleotide sequence and expression of an intracellular protein tyrosine phosphatase from mouse testis.

PubMed ID: 1378268

DOI: 10.1016/0006-291x(92)91700-z

PubMed ID: 7832766

Title: A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain.

PubMed ID: 7832766

DOI: 10.1042/bj3050499

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 432
Mass: 49593
Checksum: 4843D2DD4C288C48
Sequence:

MEMEKEFEEI DKAGNWAAIY QDIRHEASDF PCKVAKLPKN KNRNRYRDVS PFDHSRIKLH 
QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRIMEKGSLK 
CAQYWPQQEE KEMVFDDTGL KLTLISEDVK SYYTVRQLEL ENLTTKETRE ILHFHYTTWP 
DFGVPESPAS FLNFLFKVRE SGSLSLEHGP IVVHCSAGIG RSGTFCLADT CLLLMDKRKD 
PSSVDIKKVL LEMRRFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSREDLD 
LPPEHVPPPP RPPKRTLEPH NGKCKELFSS HQWVSEETCG DEDSLAREEG RAQSSAMHSV 
SSMSPDTEVR RRMVGGGLQS AQASVPTEEE LSSTEEEHKA HWPSHWKPFL VNVCMATLLA 
TGAYLCYRVC FH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ptpn1

Associated with

Other Information

Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. PubMed ID: 1932742

The cDNA cloning, nucleotide sequence and expression of an intracellular protein tyrosine phosphatase from mouse testis. PubMed ID: 1378268

A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain. PubMed ID: 7832766

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355