Genular: Defining Cellular Identity and Function

Details for: Dusp1

Gene ID: 19252

Symbol: Dusp1

Ensembl ID: ENSMUSG00000024190

Description: dual specificity phosphatase 1

Associated with

Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of mapk pathway
(R-MMU-5675221)
Raf-independent mapk1/3 activation
(R-MMU-112409)
Raf/map kinase cascade
(R-MMU-5673001)
Signal transduction
(R-MMU-162582)
Cell cycle
(GO:0007049)
Cellular response to chemokine
(GO:1990869)
Cytoplasm
(GO:0005737)
Dephosphorylation
(GO:0016311)
Endoderm formation
(GO:0001706)
Growth factor binding
(GO:0019838)
Hydrolase activity
(GO:0016787)
Intracellular signal transduction
(GO:0035556)
Map kinase tyrosine/serine/threonine phosphatase activity
(GO:0017017)
Map kinase tyrosine phosphatase activity
(GO:0033550)
Mitogen-activated protein kinase binding
(GO:0051019)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna biosynthetic process
(GO:2000279)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of mapk cascade
(GO:0043409)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of monocyte chemotaxis
(GO:0090027)
Negative regulation of p38mapk cascade
(GO:1903753)
Nucleus
(GO:0005634)
Peptidyl-serine dephosphorylation
(GO:0070262)
Peptidyl-threonine dephosphorylation
(GO:0035970)
Peptidyl-tyrosine dephosphorylation
(GO:0035335)
Phosphatase activity
(GO:0016791)
Phosphoprotein phosphatase activity
(GO:0004721)
Positive regulation of apoptotic process
(GO:0043065)
Protein dephosphorylation
(GO:0006470)
Protein serine/threonine phosphatase activity
(GO:0004722)
Protein tyrosine/serine/threonine phosphatase activity
(GO:0008138)
Protein tyrosine/threonine phosphatase activity
(GO:0008330)
Protein tyrosine phosphatase activity
(GO:0004725)

Other Information

Proteins

DUS1_MOUSE

Genular Protein ID: 3897024695

Symbol: DUS1_MOUSE

Name: N/A

UniProtKB Accession Codes:

P28563

Database IDs:

Citations:

PubMed ID: 1741163

Title: cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.

PubMed ID: 1741163

PubMed ID: 8355678

Title: Structure, mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth.

PubMed ID: 8355678

DOI: 10.1128/mcb.13.9.5195-5205.1993

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8221888

Title: MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo.

PubMed ID: 8221888

DOI: 10.1016/0092-8674(93)90383-2

PubMed ID: 10617468

Title: Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.

PubMed ID: 10617468

DOI: 10.1126/science.286.5449.2514

Sequence Information:

Length: 367
Mass: 39370
Checksum: 50B5F90FEBBD19AB
Sequence:

MVMEVGILDA GGLRALLREG AAQCLLLDCR SFFAFNAGHI AGSVNVRFST IVRRRAKGAM 
GLEHIVPNAE LRGRLLAGAY HAVVLLDERS ASLDGAKRDG TLALAAGALC REARSTQVFF 
LQGGYEAFSA SCPELCSKQS TPTGLSLPLS TSVPDSAESG CSSCSTPLYD QGGPVEILSF 
LYLGSAYHAS RKDMLDALGI TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA 
IDFIDSIKDA GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS 
FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHPT NSALNYLKSP 
ITTSPSC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dusp1

Associated with

Other Information

cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. PubMed ID: 1741163

Structure, mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth. PubMed ID: 8355678

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334