Details for: Ptpn2

Gene ID: 19255

Symbol: Ptpn2

Ensembl ID: ENSMUSG00000024539

Description: protein tyrosine phosphatase, non-receptor type 2

Associated with

  • Antiviral mechanism by ifn-stimulated genes
    (R-MMU-1169410)
  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Immune system
    (R-MMU-168256)
  • Interferon gamma signaling
    (R-MMU-877300)
  • Interferon signaling
    (R-MMU-913531)
  • Negative regulation of met activity
    (R-MMU-6807004)
  • Pkr-mediated signaling
    (R-MMU-9833482)
  • Regulation of ifng signaling
    (R-MMU-877312)
  • Signaling by met
    (R-MMU-6806834)
  • Signaling by receptor tyrosine kinases
    (R-MMU-9006934)
  • Signal transduction
    (R-MMU-162582)
  • B cell differentiation
    (GO:0030183)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Dephosphorylation
    (GO:0016311)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum-golgi intermediate compartment
    (GO:0005793)
  • Endosome lumen
    (GO:0031904)
  • Erythrocyte differentiation
    (GO:0030218)
  • Glucose homeostasis
    (GO:0042593)
  • Hydrolase activity
    (GO:0016787)
  • Insulin receptor recycling
    (GO:0038020)
  • Insulin receptor signaling pathway
    (GO:0008286)
  • Integrin binding
    (GO:0005178)
  • Membrane
    (GO:0016020)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of chemotaxis
    (GO:0050922)
  • Negative regulation of epidermal growth factor receptor signaling pathway
    (GO:0042059)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of insulin receptor signaling pathway
    (GO:0046627)
  • Negative regulation of interleukin-2-mediated signaling pathway
    (GO:1902206)
  • Negative regulation of interleukin-4-mediated signaling pathway
    (GO:1902215)
  • Negative regulation of interleukin-6-mediated signaling pathway
    (GO:0070104)
  • Negative regulation of lipid storage
    (GO:0010888)
  • Negative regulation of macrophage colony-stimulating factor signaling pathway
    (GO:1902227)
  • Negative regulation of macrophage differentiation
    (GO:0045650)
  • Negative regulation of platelet-derived growth factor receptor-beta signaling pathway
    (GO:2000587)
  • Negative regulation of positive thymic t cell selection
    (GO:1902233)
  • Negative regulation of protein tyrosine kinase activity
    (GO:0061099)
  • Negative regulation of receptor signaling pathway via jak-stat
    (GO:0046426)
  • Negative regulation of t cell receptor signaling pathway
    (GO:0050860)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010804)
  • Negative regulation of type ii interferon-mediated signaling pathway
    (GO:0060336)
  • Negative regulation of type i interferon-mediated signaling pathway
    (GO:0060339)
  • Negative regulation of tyrosine phosphorylation of stat protein
    (GO:0042532)
  • Non-membrane spanning protein tyrosine phosphatase activity
    (GO:0004726)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Peptidyl-tyrosine dephosphorylation
    (GO:0035335)
  • Phosphatase activity
    (GO:0016791)
  • Phosphoprotein phosphatase activity
    (GO:0004721)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902237)
  • Positive regulation of gluconeogenesis
    (GO:0045722)
  • Positive regulation of perk-mediated unfolded protein response
    (GO:1903899)
  • Protein binding
    (GO:0005515)
  • Protein dephosphorylation
    (GO:0006470)
  • Protein kinase binding
    (GO:0019901)
  • Protein tyrosine phosphatase activity
    (GO:0004725)
  • Receptor tyrosine kinase binding
    (GO:0030971)
  • Regulation of hepatocyte growth factor receptor signaling pathway
    (GO:1902202)
  • Stat family protein binding
    (GO:0097677)
  • Syntaxin binding
    (GO:0019905)
  • T cell differentiation
    (GO:0030217)

Other Information

Genular Protein ID: 1794191322

Symbol: PTN2_MOUSE

Name: Tyrosine-protein phosphatase non-receptor type 2

UniProtKB Accession Codes:

Q06180 Q3V259 Q922E7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 EC 2 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 48 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 3 SMART 2 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 2 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 1731319

Title: Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase.

PubMed ID: 1731319

DOI: 10.1073/pnas.89.2.499

PubMed ID: 1283199

Title: Molecular cloning, nucleotide sequence and expression of a cDNA encoding an intracellular protein tyrosine phosphatase, PTPase-2, from mouse testis and T-cells.

PubMed ID: 1283199

DOI: 10.1007/bf00249698

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9271584

Title: Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice.

PubMed ID: 9271584

DOI: 10.1084/jem.186.5.683

PubMed ID: 11498795

Title: Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-kappaB activation.

PubMed ID: 11498795

DOI: 10.1038/sj.onc.1204648

PubMed ID: 11909529

Title: The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.

PubMed ID: 11909529

DOI: 10.1016/s0960-9822(02)00697-8

PubMed ID: 12138178

Title: Identification of a nuclear Stat1 protein tyrosine phosphatase.

PubMed ID: 12138178

DOI: 10.1128/mcb.22.16.5662-5668.2002

PubMed ID: 11773439

Title: A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus.

PubMed ID: 11773439

DOI: 10.1210/mend.16.1.0761

PubMed ID: 24319783

Title: Retraction.

PubMed ID: 24319783

DOI: 10.1210/me.2013-1264

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 14726372

Title: T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease.

PubMed ID: 14726372

DOI: 10.1182/blood-2003-09-3153

PubMed ID: 14966296

Title: Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.

PubMed ID: 14966296

DOI: 10.1128/mcb.24.5.2190-2201.2004

PubMed ID: 15696169

Title: Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase.

PubMed ID: 15696169

DOI: 10.1038/ni1169

PubMed ID: 16705167

Title: T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation.

PubMed ID: 16705167

DOI: 10.1128/mcb.01932-05

PubMed ID: 17210636

Title: T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6.

PubMed ID: 17210636

DOI: 10.1128/mcb.01234-06

PubMed ID: 20484139

Title: T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis.

PubMed ID: 20484139

DOI: 10.2337/db09-1365

PubMed ID: 22080863

Title: T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.

PubMed ID: 22080863

DOI: 10.1172/jci59492

PubMed ID: 22124607

Title: T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice.

PubMed ID: 22124607

DOI: 10.1007/s00125-011-2386-z

Sequence Information:

  • Length: 406
  • Mass: 47360
  • Checksum: DFB881DF3C800DC3
  • Sequence:
    • MSATIEREFE ELDAQCRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD VSPYDHSRVK 
LQSTENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM VWQQKTKAVV MLNRTVEKES 
VKCAQYWPTD DREMVFKETG FSVKLLSEDV KSYYTVHLLQ LENINTGETR TISHFHYTTW 
PDFGVPESPA SFLNFLFKVR ESGCLTPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGE 
DVNVKQLLLN MRKYRMGLIQ TPDQLRFSYM AIIEGAKYTK GDSNIQKRWK ELSKEDLSPI 
CDHSQNRVMV EKYNGKRIGS EDEKLTGLPS KVQDTVEESS ESILRKRIRE DRKATTAQKV 
QQMKQRLNET ERKRKRWLYW QPILTKMGFV SVILVGALVG WTLLFH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.