Details for: Ptpn22

Gene ID: 19260

Symbol: Ptpn22

Ensembl ID: ENSMUSG00000027843

Description: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

Associated with

  • Adaptive immune system
    (R-MMU-1280218)
  • Immune system
    (R-MMU-168256)
  • Phosphorylation of cd3 and tcr zeta chains
    (R-MMU-202427)
  • Tcr signaling
    (R-MMU-202403)
  • Translocation of zap-70 to immunological synapse
    (R-MMU-202430)
  • Autophagy
    (GO:0006914)
  • Cellular response to muramyl dipeptide
    (GO:0071225)
  • Cytoplasm
    (GO:0005737)
  • Cytoplasmic side of plasma membrane
    (GO:0009898)
  • Dephosphorylation
    (GO:0016311)
  • Hydrolase activity
    (GO:0016787)
  • Immune system process
    (GO:0002376)
  • Kinase binding
    (GO:0019900)
  • Lipid metabolic process
    (GO:0006629)
  • Lipopolysaccharide-mediated signaling pathway
    (GO:0031663)
  • Negative regulation of autophagy
    (GO:0010507)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of interleukin-8 production
    (GO:0032717)
  • Negative regulation of jun kinase activity
    (GO:0043508)
  • Negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
    (GO:0070433)
  • Negative regulation of p38mapk cascade
    (GO:1903753)
  • Negative regulation of t cell activation
    (GO:0050868)
  • Negative regulation of t cell receptor signaling pathway
    (GO:0050860)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Non-membrane spanning protein tyrosine phosphatase activity
    (GO:0004726)
  • Nucleus
    (GO:0005634)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Phosphatase activity
    (GO:0016791)
  • Phosphoanandamide dephosphorylation
    (GO:0035644)
  • Phosphoprotein phosphatase activity
    (GO:0004721)
  • Positive regulation of cd8-positive, alpha-beta t cell proliferation
    (GO:2000566)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of granzyme b production
    (GO:0071663)
  • Positive regulation of interferon-alpha production
    (GO:0032727)
  • Positive regulation of interferon-beta production
    (GO:0032728)
  • Positive regulation of nlrp3 inflammasome complex assembly
    (GO:1900227)
  • Positive regulation of protein import into nucleus
    (GO:0042307)
  • Positive regulation of protein k63-linked ubiquitination
    (GO:1902523)
  • Positive regulation of toll-like receptor 3 signaling pathway
    (GO:0034141)
  • Positive regulation of toll-like receptor 4 signaling pathway
    (GO:0034145)
  • Positive regulation of toll-like receptor 7 signaling pathway
    (GO:0034157)
  • Positive regulation of toll-like receptor 9 signaling pathway
    (GO:0034165)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of type i interferon production
    (GO:0032481)
  • Protein binding
    (GO:0005515)
  • Protein dephosphorylation
    (GO:0006470)
  • Protein tyrosine kinase binding
    (GO:1990782)
  • Protein tyrosine phosphatase activity
    (GO:0004725)
  • Regulation of antigen processing and presentation
    (GO:0002577)
  • Regulation of calcium ion transmembrane transport
    (GO:1903169)
  • Regulation of leukocyte migration
    (GO:0002685)
  • Regulation of natural killer cell proliferation
    (GO:0032817)
  • Regulation of non-canonical nf-kappab signal transduction
    (GO:1901222)
  • Regulation of peptidyl-tyrosine phosphorylation
    (GO:0050730)
  • Regulation of t cell receptor signaling pathway
    (GO:0050856)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Sh3 domain binding
    (GO:0017124)
  • T cell differentiation
    (GO:0030217)
  • T cell receptor signaling pathway
    (GO:0050852)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 3250595561

Symbol: PTN22_MOUSE

Name: Tyrosine-protein phosphatase non-receptor type 22

UniProtKB Accession Codes:

P29352 Q7TMP9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DNASU 1 EC 1 ELM 1 EMBL 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 50 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 6 Rhea 5 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 1373816

Title: Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.

PubMed ID: 1373816

DOI: 10.1128/mcb.12.5.2396-2405.1992

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8890164

Title: Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.

PubMed ID: 8890164

DOI: 10.1002/j.1460-2075.1996.tb00871.x

PubMed ID: 15786712

Title: Leupaxin binds to PEST domain tyrosine phosphatase PEP.

PubMed ID: 15786712

DOI: 10.1007/s11010-005-2149-6

PubMed ID: 16938887

Title: A biosynthetic pathway for anandamide.

PubMed ID: 16938887

DOI: 10.1073/pnas.0601832103

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23871208

Title: The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.

PubMed ID: 23871208

DOI: 10.1016/j.immuni.2013.06.013

PubMed ID: 23991106

Title: Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy.

PubMed ID: 23991106

DOI: 10.1371/journal.pone.0072384

PubMed ID: 27043286

Title: NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

PubMed ID: 27043286

DOI: 10.1172/jci83669

PubMed ID: 11685249

Title: A novel, specific interaction involving the Csk SH3 domain and its natural ligand.

PubMed ID: 11685249

DOI: 10.1038/nsb1101-998

Sequence Information:

  • Length: 802
  • Mass: 89714
  • Checksum: 0F1E45339BD4613E
  • Sequence:
    • MDQREILQQL LKEAQKKKLN SEEFASEFLK LKRQSTKYKA DKIYPTTVAQ RPKNIKKNRY 
KDILPYDHSL VELSLLTSDE DSSYINASFI KGVYGPKAYI ATQGPLSTTL LDFWRMIWEY 
RILVIVMACM EFEMGKKKCE RYWAEPGETQ LQFGPFSISC EAEKKKSDYK IRTLKAKFNN 
ETRIIYQFHY KNWPDHDVPS SIDPILQLIW DMRCYQEDDC VPICIHCSAG CGRTGVICAV 
DYTWMLLKDG IIPKNFSVFN LIQEMRTQRP SLVQTQEQYE LVYSAVLELF KRHMDVISDN 
HLGREIQAQC SIPEQSLTVE ADSCPLDLPK NAMRDVKTTN QHSKQGAEAE STGGSSLGLR 
TSTMNAEEEL VLHSAKSSPS FNCLELNCGC NNKAVITRNG QARASPVVGE PLQKYQSLDF 
GSMLFGSCPS ALPINTADRY HNSKGPVKRT KSTPFELIQQ RKTNDLAVGD GFSCLESQLH 
EHYSLRELQV QRVAHVSSEE LNYSLPGACD ASCVPRHSPG ALRVHLYTSL AEDPYFSSSP 
PNSADSKMSF DLPEKQDGAT SPGALLPASS TTSFFYSNPH DSLVMNTLTS FSPPLNQETA 
VEAPSRRTDD EIPPPLPERT PESFIVVEEA GEPSPRVTES LPLVVTFGAS PECSGTSEMK 
SHDSVGFTPS KNVKLRSPKS DRHQDGSPPP PLPERTLESF FLADEDCIQA QAVQTSSTSY 
PETTENSTSS KQTLRTPGKS FTRSKSLKIF RNMKKSVCNS SSPSKPTERV QPKNSSSFLN 
FGFGNRFSKP KGPRNPPSAW NM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.