Genular: Defining Cellular Identity and Function

Details for: Ptprc

Gene ID: 19264

Symbol: Ptprc

Ensembl ID: ENSMUSG00000026395

Description: protein tyrosine phosphatase receptor type C

Associated with

Adaptive immune system
(R-MMU-1280218)
Axon guidance
(R-MMU-422475)
Developmental biology
(R-MMU-1266738)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Nervous system development
(R-MMU-9675108)
Neutrophil degranulation
(R-MMU-6798695)
Other semaphorin interactions
(R-MMU-416700)
Phosphorylation of cd3 and tcr zeta chains
(R-MMU-202427)
Semaphorin interactions
(R-MMU-373755)
Tcr signaling
(R-MMU-202403)
Alpha-beta t cell proliferation
(GO:0046633)
Ankyrin binding
(GO:0030506)
B cell differentiation
(GO:0030183)
B cell proliferation
(GO:0042100)
B cell receptor signaling pathway
(GO:0050853)
Bone marrow development
(GO:0048539)
Calcium-mediated signaling using intracellular calcium source
(GO:0035584)
Cell cycle phase transition
(GO:0044770)
Cellular response to extracellular stimulus
(GO:0031668)
Defense response to virus
(GO:0051607)
Dephosphorylation
(GO:0016311)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Gamma-delta t cell differentiation
(GO:0042492)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Heparan sulfate proteoglycan binding
(GO:0043395)
Heparin binding
(GO:0008201)
Heterotypic cell-cell adhesion
(GO:0034113)
Hydrolase activity
(GO:0016787)
Leukocyte cell-cell adhesion
(GO:0007159)
Mapk cascade
(GO:0000165)
Natural killer cell differentiation
(GO:0001779)
Negative regulation of cell adhesion involved in substrate-bound cell migration
(GO:0006933)
Negative regulation of cytokine-mediated signaling pathway
(GO:0001960)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of interleukin-2 production
(GO:0032703)
Negative regulation of peptidyl-tyrosine phosphorylation
(GO:0050732)
Negative regulation of protein autophosphorylation
(GO:0031953)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of protein tyrosine kinase activity
(GO:0061099)
Negative regulation of t cell mediated cytotoxicity
(GO:0001915)
Negative thymic t cell selection
(GO:0045060)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phosphatase activity
(GO:0016791)
Phosphoprotein phosphatase activity
(GO:0004721)
Plasma membrane raft distribution
(GO:0044855)
Positive regulation of alpha-beta t cell proliferation
(GO:0046641)
Positive regulation of antigen receptor-mediated signaling pathway
(GO:0050857)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fc receptor mediated stimulatory signaling pathway
(GO:0060369)
Positive regulation of gamma-delta t cell differentiation
(GO:0045588)
Positive regulation of humoral immune response mediated by circulating immunoglobulin
(GO:0002925)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of isotype switching to igg isotypes
(GO:0048304)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of t cell differentiation
(GO:0045582)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Positive regulation of t cell mediated immunity
(GO:0002711)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive thymic t cell selection
(GO:0045059)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein kinase binding
(GO:0019901)
Protein tyrosine phosphatase activity
(GO:0004725)
Regulation of cell cycle
(GO:0051726)
Regulation of gene expression
(GO:0010468)
Regulation of humoral immune response mediated by circulating immunoglobulin
(GO:0002923)
Regulation of interleukin-8 production
(GO:0032677)
Regulation of phagocytosis
(GO:0050764)
Regulation of protein tyrosine kinase activity
(GO:0061097)
Regulation of receptor signaling pathway via jak-stat
(GO:0046425)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to gamma radiation
(GO:0010332)
Signaling receptor binding
(GO:0005102)
Spectrin binding
(GO:0030507)
Stem cell development
(GO:0048864)
T cell differentiation
(GO:0030217)
T cell proliferation
(GO:0042098)
T cell receptor signaling pathway
(GO:0050852)

Other Information

Proteins

Genular Protein ID: 2321364023

Symbol: PTPRC_MOUSE

Name: Leukocyte common antigen

UniProtKB Accession Codes:

P06800 E9QLT5 Q61812 Q61813 Q61814 Q61815 Q78EF1 S4R1S4 S4R2V1

Database IDs:

Citations:

PubMed ID: 2944116

Title: Sequences of Ly-5 cDNA: isoform-related diversity of Ly-5 mRNA.

PubMed ID: 2944116

DOI: 10.1073/pnas.83.18.6940

PubMed ID: 1822988

Title: Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles.

PubMed ID: 1822988

DOI: 10.1155/1991/52686

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 3037546

Title: Alternative use of 5' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages.

PubMed ID: 3037546

DOI: 10.1073/pnas.84.15.5364

PubMed ID: 3211131

Title: Organization of the Ly-5 gene.

PubMed ID: 3211131

DOI: 10.1128/mcb.8.11.4889-4895.1988

PubMed ID: 2522930

Title: Sequence conservation in potential regulatory regions of the mouse and human leukocyte common antigen gene.

PubMed ID: 2522930

DOI: 10.1016/s0021-9258(18)83337-3

PubMed ID: 3864163

Title: Cloning of Ly-5 cDNA.

PubMed ID: 3864163

DOI: 10.1073/pnas.82.21.7360

PubMed ID: 3417340

Title: Structural features of Ly-5 glycoproteins of the mouse and counterparts in other mammals.

PubMed ID: 3417340

DOI: 10.1007/bf00345505

PubMed ID: 1932742

Title: Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification.

PubMed ID: 1932742

PubMed ID: 2948186

Title: Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within B- and T-lymphocyte lineages.

PubMed ID: 2948186

DOI: 10.1073/pnas.84.1.161

PubMed ID: 3570377

Title: High sequence conservation between rat (T200) and mouse (Ly-5) leukocyte common antigens.

PubMed ID: 3570377

DOI: 10.1007/bf00404697

PubMed ID: 9148925

Title: Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II.

PubMed ID: 9148925

DOI: 10.1074/jbc.272.20.13117

PubMed ID: 10415030

Title: CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells.

PubMed ID: 10415030

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1293
Mass: 144837
Checksum: 44C3D35121181B31
Sequence:

MTMGLWLKLL AFGFALLDTE VFVTGQTPTP SDELSTTENA LLLPQSDPLP ARTTESTPPS 
ISERGNGSSE TTYHPGVLST LLPHLSPQPD SQTPSAGGAD TQTFSSQADN PTLTPAPGGG 
TDPPGVPGER TVPGTIPADT AFPVDTPSLA RNSSAASPTH TSNVSTTDIS SGASLTTLTP 
STLGLASTDP PSTTIATTTK QTCAAMFGNI TVNYTYESSN QTFKADLKDV QNAKCGNEDC 
ENVLNNLEEC SQIKNISVSN DSCAPATTID LYVPPGTDKF SLHDCTPKEK ANTSICLEWK 
TKNLDFRKCN SDNISYVLHC EPENNTKCIR RNTFIPERCQ LDNLRAQTNY TCVAEILYRG 
VKLVKNVINV QTDLGIPETP KPSCGDPAAR KTLVSWPEPV SKPESASKPH GYVLCYKNNS 
EKCKSLPNNV TSFEVESLKP YKYYEVSLLA YVNGKIQRNG TAEKCNFHTK ADRPDKVNGM 
KTSRPTDNSI NVTCGPPYET NGPKTFYILV VRSGGSFVTK YNKTNCQFYV DNLYYSTDYE 
FLVSFHNGVY EGDSVIRNES TNFNAKALII FLVFLIIVTS IALLVVLYKI YDLRKKRSSN 
LDEQQELVER DDEKQLMDVE PIHSDILLET YKRKIADEGR LFLAEFQSIP RVFSKFPIKD 
ARKPHNQNKN RYVDILPYDY NRVELSEING DAGSTYINAS YIDGFKEPRK YIAAQGPRDE 
TVDDFWRMIW EQKATVIVMV TRCEEGNRNK CAEYWPSMEE GTRAFKDIVV TINDHKRCPD 
YIIQKLNVAH KKEKATGREV THIQFTSWPD HGVPEDPHLL LKLRRRVNAF SNFFSGPIVV 
HCSAGVGRTG TYIGIDAMLE GLEAEGKVDV YGYVVKLRRQ RCLMVQVEAQ YILIHQALVE 
YNQFGETEVN LSELHSCLHN MKKRDPPSDP SPLEAEYQRL PSYRSWRTQH IGNQEENKKK 
NRNSNVVPYD FNRVPLKHEL EMSKESEPES DESSDDDSDS EETSKYINAS FVMSYWKPEM 
MIAAQGPLKE TIGDFWQMIF QRKVKVIVML TELVNGDQEV CAQYWGEGKQ TYGDMEVEMK 
DTNRASAYTL RTFELRHSKR KEPRTVYQYQ CTTWKGEELP AEPKDLVSMI QDLKQKLPKA 
SPEGMKYHKH ASILVHCRDG SQQTGLFCAL FNLLESAETE DVVDVFQVVK SLRKARPGVV 
CSYEQYQFLY DIIASIYPAQ NGQVKKTNSQ DKIEFHNEVD GGKQDANCVR PDGPLNKAQE 
DSRGVGTPEP TNSAEEPEHA ANGSASPAPT QSS

Genular Protein ID: 699993055

Symbol: Q8C6Q7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C6Q7

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 879
Mass: 99989
Checksum: 9CB9E5FCD7909D4C
Sequence:

MTMGLWLKLL AFGFALLDTE VFVTGQTPTP SDGASLTTLT PSTLGLASTD PPSTTIATTT 
KQTCAAMFGN ITVNYTYESS NQTFKADLKD VQNAKCGNED CENVLNNLEE CSQIKNISVS 
NDSCAPATTI DLYVPPGTDK FSLHDCTPKE KANTSICLEW KTKNLDFRKC NSDNISYVLH 
CEPENNTKCI RRNTFIPERC QLDNLRAQTN YTCVAEILYR GVKLVKNVIN VQTDLGIPET 
PKPSCGDPAA RKTLVSWPEP VSKPESASKP HGYVLCYKNN SEKCKSLPNN VTSFEVESLK 
PYKYYEVSLL AYVNGKIQRN GTAEKCNFHT KADRPDKVNG MKTSRPTDNS INVTCGPPYE 
TNGPKTFYIL VVRSGGSFVT KYNKTNCQFY VDNLYYSTDY EFLVSFHNGV YEGDSVIRNE 
STNFNAKALI IFLVFLIIVT SIALLVVLYK IYDLRKKRSS NLDEQQELVE RDDEKQLMDV 
EPIHSDILLE TYKRKIADEG RLFLAEFQSI PRVFSKFPIK DARKPHNQNK NRYVDILPYD 
YNRVELSEIN GDAGSTYINA SYIDGFKEPR KYIAAQGPRD ETVDDFWRMI WEQKATVIVM 
VTRCEEGNRN KCAEYWPSME EGTRAFKDIV VTINDHKRCP DYIIQKLNVA HKKEKATGRE 
VTHIQFTSWP DHGVPEDPHL LLKLRRRVNA FSNFFSGPIV VHCSAGVGRT GTYIGIDAML 
EGLEAEGKVD VYGYVVKLRR QRCLMVQVEA QYILIHQALV EYNQFGETEV NLSELHSCLH 
NMKKRDPPSD PSPLEAEYQR LPSYRSWRTQ HIGNQEENKK KNRNSNVVPY DFNRVPLKHE 
LEMSKESEPE SDESSDDDSD SEETSKYINA SFVMSYWKP

Genular Protein ID: 4113382009

Symbol: S4R1M0_MOUSE

Name: N/A

UniProtKB Accession Codes:

S4R1M0

Database IDs:

Citations:

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1130
Mass: 128570
Checksum: 70F5EDC24F9CC0BB
Sequence:

MTMGLWLKLL AFGFALLDTE VFVTGQTPTP SDATTTKQTC AAMFGNITVN YTYESSNQTF 
KADLKDVQNA KCGNEDCENV LNNLEECSQI KNISVSNDSC APATTIDLYV PPGTDKFSLH 
DCTPKEKANT SICLEWKTKN LDFRKCNSDN ISYVLHCEPE NNTKCIRRNT FIPERCQLDN 
LRAQTNYTCV AEILYRGVKL VKNVINVQTD LGIPETPKPS CGDPAARKTL VSWPEPVSKP 
ESASKPHGYV LCYKNNSEKC KSLPNNVTSF EVESLKPYKY YEVSLLAYVN GKIQRNGTAE 
KCNFHTKADR PDKVNGMKTS RPTDNSINVT CGPPYETNGP KTFYILVVRS GGSFVTKYNK 
TNCQFYVDNL YYSTDYEFLV SFHNGVYEGD SVIRNESTNF NAKALIIFLV FLIIVTSIAL 
LVVLYKIYDL RKKRSSNLDE QQELVERDDE KQLMDVEPIH SDILLETYKR KIADEGRLFL 
AEFQSIPRVF SKFPIKDARK PHNQNKNRYV DILPYDYNRV ELSEINGDAG STYINASYID 
GFKEPRKYIA AQGPRDETVD DFWRMIWEQK ATVIVMVTRC EEGNRNKCAE YWPSMEEGTR 
AFKDIVVTIN DHKRCPDYII QKLNVAHKKE KATGREVTHI QFTSWPDHGV PEDPHLLLKL 
RRRVNAFSNF FSGPIVVHCS AGVGRTGTYI GIDAMLEGLE AEGKVDVYGY VVKLRRQRCL 
MVQVEAQYIL IHQALVEYNQ FGETEVNLSE LHSCLHNMKK RDPPSDPSPL EAEYQRLPSY 
RSWRTQHIGN QEENKKKNRN SNVVPYDFNR VPLKHELEMS KESEPESDES SDDDSDSEET 
SKYINASFVM SYWKPEMMIA AQGPLKETIG DFWQMIFQRK VKVIVMLTEL VNGDQEVCAQ 
YWGEGKQTYG DMEVEMKDTN RASAYTLRTF ELRHSKRKEP RTVYQYQCTT WKGEELPAEP 
KDLVSMIQDL KQKLPKASPE GMKYHKHASI LVHCRDGSQQ TGLFCALFNL LESAETEDVV 
DVFQVVKSLR KARPGVVCSY EQYQFLYDII ASIYPAQNGQ VKKTNSQDKI EFHNEVDGGK 
QDANCVRPDG PLNKAQEDSR GVGTPEPTNS AEEPEHAANG SASPAPTQSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ptprc

Associated with

Other Information

Sequences of Ly-5 cDNA: isoform-related diversity of Ly-5 mRNA. PubMed ID: 2944116

Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles. PubMed ID: 1822988

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Alternative use of 5' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages. PubMed ID: 3037546

Organization of the Ly-5 gene. PubMed ID: 3211131

Sequence conservation in potential regulatory regions of the mouse and human leukocyte common antigen gene. PubMed ID: 2522930

Cloning of Ly-5 cDNA. PubMed ID: 3864163

Structural features of Ly-5 glycoproteins of the mouse and counterparts in other mammals. PubMed ID: 3417340

Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. PubMed ID: 1932742

Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within B- and T-lymphocyte lineages. PubMed ID: 2948186

High sequence conservation between rat (T200) and mouse (Ly-5) leukocyte common antigens. PubMed ID: 3570377

Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II. PubMed ID: 9148925

CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells. PubMed ID: 10415030

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 2944116

PubMed ID: 1822988

PubMed ID: 19468303

PubMed ID: 3037546

PubMed ID: 3211131

PubMed ID: 2522930

PubMed ID: 3864163

PubMed ID: 3417340

PubMed ID: 1932742

PubMed ID: 2948186

PubMed ID: 3570377

PubMed ID: 9148925

PubMed ID: 10415030

PubMed ID: 19144319

PubMed ID: 21183079

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 19144319

PubMed ID: 19468303

PubMed ID: 21183079