Genular: Defining Cellular Identity and Function

Details for: Pex2

Gene ID: 19302

Symbol: Pex2

Ensembl ID: ENSMUSG00000040374

Description: peroxisomal biogenesis factor 2

Associated with

Class i peroxisomal membrane protein import
(R-MMU-9603798)
E3 ubiquitin ligases ubiquitinate target proteins
(R-MMU-8866654)
Metabolism of proteins
(R-MMU-392499)
Peroxisomal protein import
(R-MMU-9033241)
Post-translational protein modification
(R-MMU-597592)
Protein localization
(R-MMU-9609507)
Protein ubiquitination
(R-MMU-8852135)
Bile acid biosynthetic process
(GO:0006699)
Cdc73/paf1 complex
(GO:0016593)
Cellular response to reactive oxygen species
(GO:0034614)
Cholesterol homeostasis
(GO:0042632)
Fatty acid beta-oxidation
(GO:0006635)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of fibroblast proliferation
(GO:0048147)
Nervous system development
(GO:0007399)
Neuron migration
(GO:0001764)
Peroxisomal membrane
(GO:0005778)
Peroxisome
(GO:0005777)
Peroxisome organization
(GO:0007031)
Pexophagy
(GO:0000425)
Protein destabilization
(GO:0031648)
Protein import into peroxisome matrix
(GO:0016558)
Protein import into peroxisome matrix, receptor recycling
(GO:0016562)
Protein monoubiquitination
(GO:0006513)
Protein transport
(GO:0015031)
Regulation of cholesterol biosynthetic process
(GO:0045540)
Response to amino acid starvation
(GO:1990928)
Transferase activity
(GO:0016740)
Ubiquitin protein ligase activity
(GO:0061630)
Very long-chain fatty acid metabolic process
(GO:0000038)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Peroxisomal membrane protein 3
Q91YZ5_MOUSE

Genular Protein ID: 2507120972

Symbol: PEX2_MOUSE

Name: Peroxisomal membrane protein 3

UniProtKB Accession Codes:

P55098 O35467

Database IDs:

Citations:

PubMed ID: 8043297

Title: Structure and expression of mammalian peroxisome assembly factor-1 (PMP35) genes.

PubMed ID: 8043297

DOI: 10.1006/bmmb.1994.1018

PubMed ID: 9382874

Title: Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder.

PubMed ID: 9382874

DOI: 10.1083/jcb.139.5.1293

PubMed ID: 12746876

Title: Abnormal cerebellar histogenesis in PEX2 Zellweger mice reflects multiple neuronal defects induced by peroxisome deficiency.

PubMed ID: 12746876

DOI: 10.1002/cne.10699

PubMed ID: 14673138

Title: Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model.

PubMed ID: 14673138

DOI: 10.1128/mcb.24.1.1-13.2004

PubMed ID: 19110480

Title: Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.

PubMed ID: 19110480

DOI: 10.1074/jbc.m809064200

PubMed ID: 22441164

Title: Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice.

PubMed ID: 22441164

DOI: 10.1016/j.bbalip.2012.02.011

PubMed ID: 33163488

Title: Peroxisome deficiency impairs BDNF signaling and memory.

PubMed ID: 33163488

DOI: 10.3389/fcell.2020.567017

PubMed ID: 34903883

Title: Peroxisomal beta-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis.

PubMed ID: 34903883

DOI: 10.1038/s42255-021-00489-2

Sequence Information:

Length: 305
Mass: 34732
Checksum: FAFB6C8913F959F0
Sequence:

MAAREESTQS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA RFEPEVKAFL 
WLFLWRFTIY SKNATVGQSV LNIQHKNDSS PNPVYQPPSK NQKLLYAVCT IGGRWLEERC 
YDLFRNRHLA SFGKAKQCMN FVVGLLKLGE LMNFLIFLQK GKFATLTERL LGIHSVFCKP 
QNMREVGFEY MNRELLWHGF AEFLIFLLPL INIQKLKAKL SSWCTLCTGA AGHDSTLGSS 
GKECALCGEW PTMPHTIGCE HVFCYYCVKS SFLFDIYFTC PKCGTEVHSV QPLKAGIQMS 
EVNAL

Genular Protein ID: 2960434501

Symbol: Q91YZ5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q91YZ5

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 305
Mass: 34944
Checksum: CD45AEAF4B297907
Sequence:

MTGKEENMQS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA RFEPEVKAFL 
WLFLWRFTIY SKNATVGQSV LNIQYKNDSS LNLIYQPPSK TQKLWYAVCT IGGKWLEERC 
YDLFRNRHLA SFGKAKQFMN FLVGLLKLGE LINFLIFLQK GKFATLTERL LGIHSVFCKP 
QNMREVGFEY MNRELLWHGF AEFLIFLLPL INIQKLKAKL SSWCIPLTGA AGHDSTLGSS 
GKECALCGEW PTMPHTIGCE HVFCYYCVKS SFLFDIYFTC PKCGTEVHSV QPLKSGIEMS 
EVNAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pex2

Associated with

Other Information

Structure and expression of mammalian peroxisome assembly factor-1 (PMP35) genes. PubMed ID: 8043297

Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder. PubMed ID: 9382874

Abnormal cerebellar histogenesis in PEX2 Zellweger mice reflects multiple neuronal defects induced by peroxisome deficiency. PubMed ID: 12746876

Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model. PubMed ID: 14673138

Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress. PubMed ID: 19110480

Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice. PubMed ID: 22441164

Peroxisome deficiency impairs BDNF signaling and memory. PubMed ID: 33163488

Peroxisomal beta-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis. PubMed ID: 34903883

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303