Genular: Defining Cellular Identity and Function

Details for: Pex5

Gene ID: 19305

Symbol: Pex5

Ensembl ID: ENSMUSG00000005069

Description: peroxisomal biogenesis factor 5

Associated with

Autophagy
(R-MMU-9612973)
E3 ubiquitin ligases ubiquitinate target proteins
(R-MMU-8866654)
Macroautophagy
(R-MMU-1632852)
Metabolism of proteins
(R-MMU-392499)
Peroxisomal protein import
(R-MMU-9033241)
Post-translational protein modification
(R-MMU-597592)
Protein localization
(R-MMU-9609507)
Protein ubiquitination
(R-MMU-8852135)
Selective autophagy
(R-MMU-9663891)
Cell development
(GO:0048468)
Cellular lipid metabolic process
(GO:0044255)
Cellular response to reactive oxygen species
(GO:0034614)
Cerebral cortex cell migration
(GO:0021795)
Cerebral cortex neuron differentiation
(GO:0021895)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endoplasmic reticulum organization
(GO:0007029)
Enzyme binding
(GO:0019899)
Fatty acid beta-oxidation
(GO:0006635)
Golgi apparatus
(GO:0005794)
Isoprenoid biosynthetic process
(GO:0008299)
Membrane
(GO:0016020)
Mitochondrial membrane organization
(GO:0007006)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Neuromuscular process
(GO:0050905)
Neuron migration
(GO:0001764)
Peroxisomal matrix
(GO:0005782)
Peroxisomal membrane
(GO:0005778)
Peroxisome
(GO:0005777)
Peroxisome matrix targeting signal-1 binding
(GO:0005052)
Peroxisome membrane targeting sequence binding
(GO:0033328)
Peroxisome organization
(GO:0007031)
Peroxisome targeting sequence binding
(GO:0000268)
Pexophagy
(GO:0000425)
Positive regulation of multicellular organism growth
(GO:0040018)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein carrier chaperone
(GO:0140597)
Protein import into peroxisome matrix
(GO:0016558)
Protein import into peroxisome matrix, docking
(GO:0016560)
Protein import into peroxisome matrix, receptor recycling
(GO:0016562)
Protein import into peroxisome matrix, substrate release
(GO:0044721)
Protein import into peroxisome matrix, translocation
(GO:0016561)
Protein import into peroxisome membrane
(GO:0045046)
Protein targeting to peroxisome
(GO:0006625)
Protein tetramerization
(GO:0051262)
Protein transport
(GO:0015031)
Small gtpase binding
(GO:0031267)
Very long-chain fatty acid metabolic process
(GO:0000038)

Other Information

Proteins

PTS1-BP

Genular Protein ID: 2349616447

Symbol: PEX5_MOUSE

Name: PTS1-BP

UniProtKB Accession Codes:

O09012 Q3UM58 Q8K2V5 Q91YC7

Database IDs:

Citations:

PubMed ID: 9288097

Title: A mouse model for Zellweger syndrome.

PubMed ID: 9288097

DOI: 10.1038/ng0997-49

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 15732085

Title: Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities.

PubMed ID: 15732085

DOI: 10.1002/hep.20628

PubMed ID: 17442273

Title: Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts.

PubMed ID: 17442273

DOI: 10.1016/j.bbrc.2007.03.198

PubMed ID: 33389129

Title: A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes.

PubMed ID: 33389129

DOI: 10.1007/s00439-020-02238-z

Sequence Information:

Length: 639
Mass: 70756
Checksum: A7013FF02926803C
Sequence:

MAMRELVEGE CGGANPLMKL ATHFTQDKAL RQEGLRPGPW PPGASAAETV SKPLGVGTED 
ELVSEFLQDQ NATLVSRAPQ TFKMDDLLAE MQEIEQSNFR QAPQRAPGVA DLALSENWAQ 
EFLAAGDAVD VAQDYNETDW SQEFIAEVTD PLSVSPARWA EEYLEQSEEK LWLGDQEGSS 
TADRWYDEYH PEEDLQHTAS DFVSKVDDPK LANSEFLKFV RQIGEGQVSL ESAAGSGGAQ 
AEQWAAEFIQ QQGTSEAWVD QFTRPGNKIA ALQVEFERAK SAIESDVDFW DKLQAELEEM 
AKRDAEAHPW LSDYDDLTSA SYDKGYQFEE ENPLRDHPQP FEEGLHRLEE GDLPNAVLLF 
EAAVQQDPKH MEAWQYLGTT QAENEQELLA ISALRRCLEL KPDNRTALMA LAVSFTNESL 
QRQACETLRD WLRYSPAYAH LVAPGEEGAT GAGPSKRILG SLLSDSLFLE VKDLFLAAVR 
LDPTSIDPDV QCGLGVLFNL SGEYDKAVDC FTAALSVRPN DYLMWNKLGA TLANGNQSEE 
AVAAYRRALE LQPGYIRSRY NLGISCINLG AHREAVEHFL EALNMQRKSR GPRGEGGAMS 
ENIWSTLRLA LSMLGQSDAY GAADARDLSA LLAMFGLPQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pex5

Associated with

Other Information

A mouse model for Zellweger syndrome. PubMed ID: 9288097

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities. PubMed ID: 15732085

Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts. PubMed ID: 17442273

A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes. PubMed ID: 33389129