Details for: Qki
Associated with
Other Information
Genular Protein ID: 4247517205
Symbol: QKI_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8589716
Title: The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins.
PubMed ID: 8589716
DOI: 10.1038/ng0396-260
PubMed ID: 10384037
Title: Genomic organization and expression analysis of the mouse qkI locus.
PubMed ID: 10384037
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10328999
Title: Contrasting effects of ENU induced embryonic lethal mutations of the quaking gene.
PubMed ID: 10328999
PubMed ID: 8987822
Title: Neural cell type-specific expression of QKI proteins is altered in quakingviable mutant mice.
PubMed ID: 8987822
PubMed ID: 9315629
Title: Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and Qk1: role of the KH domain.
PubMed ID: 9315629
PubMed ID: 9778149
Title: QKI expression is regulated during neuron-glial cell fate decisions.
PubMed ID: 9778149
DOI: 10.1002/(sici)1097-4547(19981001)54:1<46::aid-jnr6>3.0.co;2-h
PubMed ID: 9671495
Title: Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization.
PubMed ID: 9671495
PubMed ID: 10506177
Title: The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm.
PubMed ID: 10506177
PubMed ID: 10535969
Title: The STAR protein QKI-6 is a translational repressor.
PubMed ID: 10535969
PubMed ID: 10864952
Title: Destabilization and mislocalization of myelin basic protein mRNAs in quaking dysmyelination lacking the QKI RNA-binding proteins.
PubMed ID: 10864952
PubMed ID: 11297509
Title: Nuclear translocation controlled by alternatively spliced isoforms inactivates the QUAKING apoptotic inducer.
PubMed ID: 11297509
DOI: 10.1101/gad.860301
PubMed ID: 12467586
Title: Nuclear retention of MBP mRNAs in the quaking viable mice.
PubMed ID: 12467586
PubMed ID: 11917126
Title: Function of quaking in myelination: regulation of alternative splicing.
PubMed ID: 11917126
PubMed ID: 11892011
Title: Quaking is essential for blood vessel development.
PubMed ID: 11892011
DOI: 10.1002/gene.10060
PubMed ID: 12682013
Title: Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism.
PubMed ID: 12682013
DOI: 10.1093/emboj/cdg171
PubMed ID: 12529443
Title: Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1.
PubMed ID: 12529443
PubMed ID: 12888522
Title: The quakingviable mutation affects qkI mRNA expression specifically in myelin-producing cells of the nervous system.
PubMed ID: 12888522
DOI: 10.1093/nar/gkg635
PubMed ID: 15014970
Title: The neurological mutant quaking(viable) is Parkin deficient.
PubMed ID: 15014970
PubMed ID: 16198329
Title: STAR proteins quaking-6 and GLD-1 regulate translation of the homologues GLI1 and tra-1 through a conserved RNA 3'UTR-based mechanism.
PubMed ID: 16198329
PubMed ID: 14706070
Title: Defective smooth muscle development in qkI-deficient mice.
PubMed ID: 14706070
PubMed ID: 15528192
Title: Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation.
PubMed ID: 15528192
PubMed ID: 15568022
Title: Protection of p27(Kip1) mRNA by quaking RNA binding proteins promotes oligodendrocyte differentiation.
PubMed ID: 15568022
DOI: 10.1038/nn1359
PubMed ID: 16041388
Title: Target RNA motif and target mRNAs of the Quaking STAR protein.
PubMed ID: 16041388
DOI: 10.1038/nsmb963
PubMed ID: 16470614
Title: Visceral endoderm function is regulated by quaking and required for vascular development.
PubMed ID: 16470614
DOI: 10.1002/gene.20189
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20956316
Title: Quaking I controls a unique cytoplasmic pathway that regulates alternative splicing of myelin-associated glycoprotein.
PubMed ID: 20956316
PubMed ID: 21253564
Title: Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells.
PubMed ID: 21253564
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 28188285
Title: RNA-binding protein Quaking stabilizes Sirt2 mRNA during oligodendroglial differentiation.
PubMed ID: 28188285
PubMed ID: 29021242
Title: Autogenous cross-regulation of Quaking mRNA processing and translation balances Quaking functions in splicing and translation.
PubMed ID: 29021242
PubMed ID: 33378678
Title: QUAKING regulates microexon alternative splicing of the Rho GTPase pathway and controls microglia homeostasis.
PubMed ID: 33378678
PubMed ID: 31868295
Title: QKI regulates adipose tissue metabolism by acting as a brake on thermogenesis and promoting obesity.
PubMed ID: 31868295
PubMed ID: 32732889
Title: Targeting QKI-7 in vivo restores endothelial cell function in diabetes.
PubMed ID: 32732889
PubMed ID: 33942715
Title: Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis.
PubMed ID: 33942715
DOI: 10.7554/elife.60467
PubMed ID: 33045062
Title: Qki is an essential regulator of microglial phagocytosis in demyelination.
PubMed ID: 33045062
DOI: 10.1084/jem.20190348
PubMed ID: 34021134
Title: Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency.
PubMed ID: 34021134
PubMed ID: 33397958
Title: QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function.
PubMed ID: 33397958
PubMed ID: 33750804
Title: Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain.
PubMed ID: 33750804
PubMed ID: 36088389
Title: QKI degradation in macrophage by RNF6 protects mice from MRSA infection via enhancing PI3K p110beta dependent autophagy.
PubMed ID: 36088389
PubMed ID: 36627242
Title: The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes.
PubMed ID: 36627242
DOI: 10.1093/cvr/cvad007
PubMed ID: 37272356
Title: Quaking regulates circular RNA production in cardiomyocytes.
PubMed ID: 37272356
DOI: 10.1242/jcs.261120
PubMed ID: 22982292
Title: Structural analysis of the quaking homodimerization interface.
PubMed ID: 22982292
Sequence Information:
- Length: 341
- Mass: 37671
- Checksum: 43E7F3A426A494C4
- Sequence:
MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI LEYPIEPSGV LGAVATKVRR HDMRVHPYQR IVTADRAATG N
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.