Genular: Defining Cellular Identity and Function

Details for: Rab10

Gene ID: 19325

Symbol: Rab10

Ensembl ID: ENSMUSG00000020671

Description: RAB10, member RAS oncogene family

Associated with

Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Neutrophil degranulation
(R-MMU-6798695)
Post-translational protein modification
(R-MMU-597592)
Rab gefs exchange gtp for gdp on rabs
(R-MMU-8876198)
Rab geranylgeranylation
(R-MMU-8873719)
Rab regulation of trafficking
(R-MMU-9007101)
Antigen processing and presentation
(GO:0019882)
Axonogenesis
(GO:0007409)
Cell projection
(GO:0042995)
Cellular response to insulin stimulus
(GO:0032869)
Cilium
(GO:0005929)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytoplasmic vesicle membrane
(GO:0030659)
Cytoskeleton
(GO:0005856)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum tubular network
(GO:0071782)
Endoplasmic reticulum tubular network organization
(GO:0071786)
Endosomal transport
(GO:0016197)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Establishment of neuroblast polarity
(GO:0045200)
Establishment of protein localization to endoplasmic reticulum membrane
(GO:0097051)
Establishment of protein localization to membrane
(GO:0090150)
Exocytic vesicle
(GO:0070382)
Gdp-dissociation inhibitor binding
(GO:0051021)
Gdp binding
(GO:0019003)
Golgi apparatus
(GO:0005794)
Golgi to plasma membrane transport
(GO:0006893)
G protein activity
(GO:0003925)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Insulin-responsive compartment
(GO:0032593)
Intracellular protein transport
(GO:0006886)
Membrane
(GO:0016020)
Myosin v binding
(GO:0031489)
Nucleotide binding
(GO:0000166)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Protein transport
(GO:0015031)
Recycling endosome
(GO:0055037)
Regulated exocytosis
(GO:0045055)
Synaptic vesicle membrane
(GO:0030672)
Trans-golgi network
(GO:0005802)
Vesicle-mediated transport
(GO:0016192)

Other Information

Proteins

Ras-related protein Rab-10

Genular Protein ID: 3156821853

Symbol: RAB10_MOUSE

Name: Ras-related protein Rab-10

UniProtKB Accession Codes:

P61027 O88386 Q9D7X6

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17403373

Title: Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane.

PubMed ID: 17403373

DOI: 10.1016/j.cmet.2007.03.001

PubMed ID: 19570034

Title: GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation.

PubMed ID: 19570034

DOI: 10.1042/bj20090624

PubMed ID: 20576682

Title: Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells.

PubMed ID: 20576682

DOI: 10.1152/ajprenal.00198.2010

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20643919

Title: Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane.

PubMed ID: 20643919

DOI: 10.1073/pnas.1009428107

PubMed ID: 21454697

Title: Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.

PubMed ID: 21454697

DOI: 10.1074/jbc.c111.228908

PubMed ID: 22908308

Title: Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes.

PubMed ID: 22908308

DOI: 10.1083/jcb.201111091

PubMed ID: 22762500

Title: TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes.

PubMed ID: 22762500

DOI: 10.1111/j.1600-0854.2012.01397.x

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

PubMed ID: 27354378

Title: SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes.

PubMed ID: 27354378

DOI: 10.1083/jcb.201509052

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

PubMed ID: 30398148

Title: A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.

PubMed ID: 30398148

DOI: 10.7554/elife.40202

Sequence Information:

Length: 200
Mass: 22541
Checksum: 7F02B8E8E46EE1E8
Sequence:

MAKKTYDLLF KLLLIGDSGV GKTCVLFRFS DDAFNTTFIS TIGIDFKIKT VELQGKKIKL 
QIWDTAGQER FHTITTSYYR GAMGIMLVYD ITNGKSFENI SKWLRNIDEH ANEDVERMLL 
GNKCDMDDKR VVPKGKGEQI AREHGIRFFE TSAKANINIE KAFLTLAEDI LRKTPVKEPN 
SENVDISSGG GVTGWKSKCC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rab10

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. PubMed ID: 17403373

GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation. PubMed ID: 19570034

Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells. PubMed ID: 20576682

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane. PubMed ID: 20643919

Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. PubMed ID: 21454697

Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. PubMed ID: 22908308

TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes. PubMed ID: 22762500

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. PubMed ID: 26824392

SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes. PubMed ID: 27354378

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. PubMed ID: 29125462

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. PubMed ID: 30398148