Genular: Defining Cellular Identity and Function

Details for: Rab12

Gene ID: 19328

Symbol: Rab12

Ensembl ID: ENSMUSG00000023460

Description: RAB12, member RAS oncogene family

Associated with

Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Rab gefs exchange gtp for gdp on rabs
(R-MMU-8876198)
Rab geranylgeranylation
(R-MMU-8873719)
Rab regulation of trafficking
(R-MMU-9007101)
Vesicle-mediated transport
(R-MMU-5653656)
Autophagosome
(GO:0005776)
Autophagy
(GO:0006914)
Cellular response to type ii interferon
(GO:0071346)
Cytoplasmic vesicle
(GO:0031410)
Endocytic recycling
(GO:0032456)
Endosome
(GO:0005768)
Endosome to lysosome transport
(GO:0008333)
Gdp binding
(GO:0019003)
Golgi apparatus
(GO:0005794)
Golgi vesicle fusion to target membrane
(GO:0048210)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Nucleotide binding
(GO:0000166)
Phagocytic vesicle
(GO:0045335)
Plasma membrane
(GO:0005886)
Positive regulation of macroautophagy
(GO:0016239)
Protein catabolic process
(GO:0030163)
Protein localization to plasma membrane
(GO:0072659)
Protein secretion
(GO:0009306)
Protein transport
(GO:0015031)
Rab protein signal transduction
(GO:0032482)
Recycling endosome membrane
(GO:0055038)
Regulation of exocytosis
(GO:0017157)
Secretory granule
(GO:0030141)
Synaptic vesicle
(GO:0008021)
Trans-golgi network transport vesicle
(GO:0030140)
Vesicle docking involved in exocytosis
(GO:0006904)

Other Information

Proteins

Ras-related protein Rab-12

Genular Protein ID: 3284969705

Symbol: RAB12_MOUSE

Name: Ras-related protein Rab-12

UniProtKB Accession Codes:

P35283 Q0PD43 Q9CUW7

Database IDs:

Citations:

PubMed ID: 16923123

Title: Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.

PubMed ID: 16923123

DOI: 10.1111/j.1365-2443.2006.00997.x

PubMed ID: 1555775

Title: The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach.

PubMed ID: 1555775

DOI: 10.1016/0378-1119(92)90387-5

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 17114649

Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

PubMed ID: 17114649

DOI: 10.1074/mcp.m600046-mcp200

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21718402

Title: Small GTPase Rab12 regulates constitutive degradation of transferrin receptor.

PubMed ID: 21718402

DOI: 10.1111/j.1600-0854.2011.01240.x

PubMed ID: 23357852

Title: M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells.

PubMed ID: 23357852

DOI: 10.4161/auto.23458

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

Sequence Information:

Length: 243
Mass: 27329
Checksum: 34E4EDC67F710510
Sequence:

MDPSAALHRR PAGGSLGAVS PALSGGQARR RKQPPRPADF KLQVIIIGSR GVGKTSLMER 
FTDDTFCEAC KSTVGVDFKI KTVELRGKKI RLQIWDTAGQ ERFNSITSAY YRSAKGIILV 
YDITKKETFD DLPKWMKMID KYASEDAELL LVGNKLDCET DREISRQQGE KFAQQITGMR 
FCEASAKDNF NVDEIFLKLV DDILKKMPLD VLRNELSNSI LSLQPEPEIP PELPPPRPHV 
RCC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rab12

Associated with

Other Information

Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. PubMed ID: 16923123

The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. PubMed ID: 1555775

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. PubMed ID: 17114649

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Small GTPase Rab12 regulates constitutive degradation of transferrin receptor. PubMed ID: 21718402

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells. PubMed ID: 23357852

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. PubMed ID: 26824392

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. PubMed ID: 29125462