Genular: Defining Cellular Identity and Function

Details for: Rab3a

Gene ID: 19339

Symbol: Rab3a

Ensembl ID: ENSMUSG00000031840

Description: RAB3A, member RAS oncogene family

Associated with

Acetylcholine neurotransmitter release cycle
(R-MMU-264642)
Dopamine neurotransmitter release cycle
(R-MMU-212676)
Gaba synthesis, release, reuptake and degradation
(R-MMU-888590)
Glutamate neurotransmitter release cycle
(R-MMU-210500)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Neuronal system
(R-MMU-112316)
Neurotransmitter release cycle
(R-MMU-112310)
Neutrophil degranulation
(R-MMU-6798695)
Norepinephrine neurotransmitter release cycle
(R-MMU-181430)
Post-translational protein modification
(R-MMU-597592)
Rab gefs exchange gtp for gdp on rabs
(R-MMU-8876198)
Rab geranylgeranylation
(R-MMU-8873719)
Rab regulation of trafficking
(R-MMU-9007101)
Serotonin neurotransmitter release cycle
(R-MMU-181429)
Transmission across chemical synapses
(R-MMU-112315)
Vesicle-mediated transport
(R-MMU-5653656)
Acrosomal vesicle
(GO:0001669)
Acrosomal vesicle exocytosis
(GO:0060478)
Atpase activator activity
(GO:0001671)
Atpase binding
(GO:0051117)
Axon
(GO:0030424)
Axonogenesis
(GO:0007409)
Calcium-ion regulated exocytosis
(GO:0017156)
Cell projection
(GO:0042995)
Clathrin-sculpted glutamate transport vesicle membrane
(GO:0060203)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Endosome
(GO:0005768)
Establishment of localization in cell
(GO:0051649)
Evoked neurotransmitter secretion
(GO:0061670)
Exocytosis
(GO:0006887)
Gdp-dissociation inhibitor binding
(GO:0051021)
Gtp-dependent protein binding
(GO:0030742)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Insulin secretion
(GO:0030073)
Lung development
(GO:0030324)
Lysosome
(GO:0005764)
Lysosome localization
(GO:0032418)
Maintenance of presynaptic active zone structure
(GO:0048790)
Membrane
(GO:0016020)
Mitochondrion organization
(GO:0007005)
Myosin v binding
(GO:0031489)
Neuromuscular synaptic transmission
(GO:0007274)
Nucleotide binding
(GO:0000166)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Plasma membrane repair
(GO:0001778)
Positive regulation of regulated secretory pathway
(GO:1903307)
Post-embryonic development
(GO:0009791)
Postsynapse
(GO:0098794)
Presynapse
(GO:0098793)
Presynaptic active zone
(GO:0048786)
Protein-containing complex
(GO:0032991)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Protein secretion
(GO:0009306)
Protein transport
(GO:0015031)
Regulated exocytosis
(GO:0045055)
Regulation of dopamine secretion
(GO:0014059)
Regulation of exocytosis
(GO:0017157)
Regulation of long-term synaptic potentiation
(GO:1900271)
Regulation of plasma membrane repair
(GO:1905684)
Regulation of presynaptic dense core granule exocytosis
(GO:0099161)
Regulation of short-term neuronal synaptic plasticity
(GO:0048172)
Regulation of synaptic vesicle exocytosis
(GO:2000300)
Regulation of synaptic vesicle fusion to presynaptic active zone membrane
(GO:0031630)
Regulation of synaptic vesicle priming
(GO:0010807)
Respiratory system process
(GO:0003016)
Response to electrical stimulus
(GO:0051602)
Secretory granule
(GO:0030141)
Sensory perception of touch
(GO:0050975)
Synapse
(GO:0045202)
Synaptic vesicle
(GO:0008021)
Synaptic vesicle clustering
(GO:0097091)
Synaptic vesicle exocytosis
(GO:0016079)
Synaptic vesicle maturation
(GO:0016188)
Synaptic vesicle membrane
(GO:0030672)
Synaptic vesicle recycling
(GO:0036465)
Synaptic vesicle transport
(GO:0048489)
Terminal bouton
(GO:0043195)
Vesicle docking involved in exocytosis
(GO:0006904)

Other Information

Proteins

Ras-related protein Rab-3A

Genular Protein ID: 79949704

Symbol: RAB3A_MOUSE

Name: Ras-related protein Rab-3A

UniProtKB Accession Codes:

P63011 P05713 Q3TSL4

Database IDs:

Citations:

PubMed ID: 7687127

Title: Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes.

PubMed ID: 7687127

DOI: 10.1042/bj2930157

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11056535

Title: cAMP-GEFII is a direct target of cAMP in regulated exocytosis.

PubMed ID: 11056535

DOI: 10.1038/35041046

PubMed ID: 11431472

Title: Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha-helix motifs.

PubMed ID: 11431472

DOI: 10.1074/jbc.m103337200

PubMed ID: 11598194

Title: Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals.

PubMed ID: 11598194

DOI: 10.1091/mbc.12.10.3095

PubMed ID: 12401793

Title: Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis.

PubMed ID: 12401793

DOI: 10.1074/jbc.m210146200

PubMed ID: 12578829

Title: Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.

PubMed ID: 12578829

DOI: 10.1074/jbc.m212341200

PubMed ID: 12590134

Title: Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.

PubMed ID: 12590134

DOI: 10.1074/jbc.m213090200

PubMed ID: 15159548

Title: Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.

PubMed ID: 15159548

DOI: 10.1073/pnas.0306709101

PubMed ID: 17509819

Title: Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.

PubMed ID: 17509819

DOI: 10.1016/j.ygeno.2007.03.013

PubMed ID: 18849981

Title: KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD.

PubMed ID: 18849981

DOI: 10.1038/ncb1785

PubMed ID: 20674857

Title: Rim2alpha determines docking and priming states in insulin granule exocytosis.

PubMed ID: 20674857

DOI: 10.1016/j.cmet.2010.05.017

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

PubMed ID: 31651360

Title: Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels.

PubMed ID: 31651360

DOI: 10.1186/s40478-019-0812-5

Sequence Information:

Length: 220
Mass: 24970
Checksum: 1A3E9F8C9D09EB40
Sequence:

MASATDSRYG QKESSDQNFD YMFKILIIGN SSVGKTSFLF RYADDSFTPA FVSTVGIDFK 
VKTIYRNDKR IKLQIWDTAG QERYRTITTA YYRGAMGFIL MYDITNEESF NAVQDWSTQI 
KTYSWDNAQV LLVGNKCDME DERVVSSERG RQLADHLGFE FFEASAKDNI NVKQTFERLV 
DVICEKMSES LDTADPAVTG AKQGPQLTDQ QAPPHQDCAC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rab3a

Associated with

Other Information

Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes. PubMed ID: 7687127

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

cAMP-GEFII is a direct target of cAMP in regulated exocytosis. PubMed ID: 11056535

Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha-helix motifs. PubMed ID: 11431472

Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals. PubMed ID: 11598194

Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis. PubMed ID: 12401793

Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. PubMed ID: 12578829

Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. PubMed ID: 12590134

Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. PubMed ID: 15159548

Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. PubMed ID: 17509819

KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD. PubMed ID: 18849981

Rim2alpha determines docking and priming states in insulin granule exocytosis. PubMed ID: 20674857

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. PubMed ID: 29125462

Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels. PubMed ID: 31651360