Genular: Defining Cellular Identity and Function

Details for: Rab7

Gene ID: 19349

Symbol: Rab7

Ensembl ID: ENSMUSG00000079477

Description: RAB7, member RAS oncogene family

Associated with

Adaptive immune system
(R-MMU-1280218)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Mhc class ii antigen presentation
(R-MMU-2132295)
Neutrophil degranulation
(R-MMU-6798695)
Post-translational protein modification
(R-MMU-597592)
Rab gefs exchange gtp for gdp on rabs
(R-MMU-8876198)
Rab geranylgeranylation
(R-MMU-8873719)
Rab regulation of trafficking
(R-MMU-9007101)
Rac1 gtpase cycle
(R-MMU-9013149)
Rac2 gtpase cycle
(R-MMU-9013404)
Rac3 gtpase cycle
(R-MMU-9013423)
Rhod gtpase cycle
(R-MMU-9013405)
Rhof gtpase cycle
(R-MMU-9035034)
Rhog gtpase cycle
(R-MMU-9013408)
Rho gtpase cycle
(R-MMU-9012999)
Rhoh gtpase cycle
(R-MMU-9013407)
Rhoq gtpase cycle
(R-MMU-9013406)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Tbc/rabgaps
(R-MMU-8854214)
Vesicle-mediated transport
(R-MMU-5653656)
Alveolar lamellar body
(GO:0097208)
Autophagosome assembly
(GO:0000045)
Autophagy
(GO:0006914)
Bone resorption
(GO:0045453)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Early endosome to late endosome transport
(GO:0045022)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Endosome to lysosome transport
(GO:0008333)
Endosome to plasma membrane protein transport
(GO:0099638)
Epidermal growth factor catabolic process
(GO:0007174)
Establishment of vesicle localization
(GO:0051650)
Gdp binding
(GO:0019003)
Golgi apparatus
(GO:0005794)
G protein activity
(GO:0003925)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Intracellular protein transport
(GO:0006886)
Intracellular transport
(GO:0046907)
Late endosome
(GO:0005770)
Late endosome membrane
(GO:0031902)
Lipid catabolic process
(GO:0016042)
Lipid droplet
(GO:0005811)
Lipid metabolic process
(GO:0006629)
Lipophagy
(GO:0061724)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Negative regulation of exosomal secretion
(GO:1903542)
Nucleotide binding
(GO:0000166)
Phagocytic vesicle
(GO:0045335)
Phagophore assembly site membrane
(GO:0034045)
Phagosome-lysosome fusion
(GO:0090385)
Phagosome acidification
(GO:0090383)
Positive regulation of exosomal secretion
(GO:1903543)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of viral process
(GO:0048524)
Protein binding
(GO:0005515)
Protein targeting to lysosome
(GO:0006622)
Protein to membrane docking
(GO:0022615)
Protein transport
(GO:0015031)
Response to bacterium
(GO:0009617)
Retrograde transport, endosome to golgi
(GO:0042147)
Retromer complex
(GO:0030904)
Retromer complex binding
(GO:1905394)
Small gtpase binding
(GO:0031267)
Synaptic vesicle membrane
(GO:0030672)
Viral release from host cell
(GO:0019076)

Other Information

Proteins

Ras-related protein Rab-7a

Genular Protein ID: 4210273753

Symbol: RAB7A_MOUSE

Name: Ras-related protein Rab-7a

UniProtKB Accession Codes:

P51150

Database IDs:

Citations:

PubMed ID: 8547311

Title: Cloning and expression analysis of the murine Rab7 cDNA.

PubMed ID: 8547311

DOI: 10.1016/0167-4781(95)00188-3

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12545426

Title: Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy.

PubMed ID: 12545426

DOI: 10.1086/367847

PubMed ID: 12972561

Title: Rabring7, a novel Rab7 target protein with a RING finger motif.

PubMed ID: 12972561

DOI: 10.1091/mbc.e02-08-0495

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20048159

Title: Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9.

PubMed ID: 20048159

DOI: 10.1074/jbc.m109.069088

PubMed ID: 23179371

Title: Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin.

PubMed ID: 23179371

DOI: 10.1007/s00401-012-1063-8

PubMed ID: 24549040

Title: C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.

PubMed ID: 24549040

DOI: 10.1093/hmg/ddu068

PubMed ID: 23708524

Title: beta-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation.

PubMed ID: 23708524

DOI: 10.4161/auto.24893

PubMed ID: 27777970

Title: PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.

PubMed ID: 27777970

DOI: 10.1172/jci.insight.86330

Sequence Information:

Length: 207
Mass: 23490
Checksum: A2AF33B16A672971
Sequence:

MTSRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV MVDDRLVTMQ 
IWDTAGQERF QSLGVAFYRG ADCCVLVFDV TAPNTFKTLD SWRDEFLIQA SPRDPENFPF 
VVLGNKIDLE NRQVATKRAQ AWCYSKNNIP YFETSAKEAI NVEQAFQTIA RNALKQETEV 
ELYNEFPEPI KLDKNDRAKA SAESCSC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rab7

Associated with

Other Information

Cloning and expression analysis of the murine Rab7 cDNA. PubMed ID: 8547311

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. PubMed ID: 12545426

Rabring7, a novel Rab7 target protein with a RING finger motif. PubMed ID: 12972561

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9. PubMed ID: 20048159

Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin. PubMed ID: 23179371

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. PubMed ID: 24549040

beta-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation. PubMed ID: 23708524

PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. PubMed ID: 27777970