Genular: Defining Cellular Identity and Function

Details for: Rad1

Gene ID: 19355

Symbol: Rad1

Ensembl ID: ENSMUSG00000022248

Description: RAD1 checkpoint DNA exonuclease

Associated with

Activation of atr in response to replication stress
(R-MMU-176187)
Cell cycle
(R-MMU-1640170)
Cell cycle checkpoints
(R-MMU-69620)
Dna double-strand break repair
(R-MMU-5693532)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Hdr through single strand annealing (ssa)
(R-MMU-5685938)
Homology directed repair
(R-MMU-5693538)
Processing of dna double-strand break ends
(R-MMU-5693607)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Rna polymerase ii transcription
(R-MMU-73857)
Transcriptional regulation by tp53
(R-MMU-3700989)
Cellular response to ionizing radiation
(GO:0071479)
Checkpoint clamp complex
(GO:0030896)
Chromosome
(GO:0005694)
Dna damage checkpoint signaling
(GO:0000077)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Double-stranded dna 3'-5' dna exonuclease activity
(GO:0008311)
Exonuclease activity
(GO:0004527)
Hydrolase activity
(GO:0016787)
Intracellular membrane-bounded organelle
(GO:0043231)
Meiotic recombination checkpoint signaling
(GO:0051598)
Nuclease activity
(GO:0004518)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)

Other Information

Proteins

Cell cycle checkpoint protein RAD1

Genular Protein ID: 3040879827

Symbol: RAD1_MOUSE

Name: Cell cycle checkpoint protein RAD1

UniProtKB Accession Codes:

Q9QWZ1 O70452 O88391 Q3TGU1 Q3UG66 Q9QWZ3

Database IDs:

Citations:

PubMed ID: 9716408

Title: Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis.

PubMed ID: 9716408

DOI: 10.1101/gad.12.16.2560

PubMed ID: 9828137

Title: A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene.

PubMed ID: 9828137

DOI: 10.1006/geno.1998.5582

PubMed ID: 9878245

Title: cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster.

PubMed ID: 9878245

DOI: 10.1006/geno.1998.5587

PubMed ID: 9660799

Title: A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease.

PubMed ID: 9660799

DOI: 10.1074/jbc.273.29.18332

PubMed ID: 9705507

Title: HRAD1 and MRad1 encode mammalian homologues of the fission yeast rad1+ cell cycle checkpoint control gene.

PubMed ID: 9705507

DOI: 10.1093/nar/26.17.3971

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 280
Mass: 31610
Checksum: F9D6ED292C5D4361
Sequence:

MPLLTQYNEE EYEQYCLVAS LDNVRNLSTV LKAIHFREHA TCFATKNGIK VTVENAKCVQ 
ANAFIQADVF QEFVIQEESV TFRINLTILL DCLSIFGSSP TPGTLTALRM CYQGYGHPLM 
LFLEEGGVVT VCKITTQEPE ETLDFDFCST NVMNKIILQS EGLREAFSEL DMTGDVLQIT 
VSPDKPYFRL STFGNAGNSH LDYPKDSDLV EAFHCDKTQV NRYKLSLLKP STKALALSCK 
VSIRTDNRGF LSLQYMIRNE DGQICFVEYY CCPDEEVPES

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rad1

Associated with

Other Information

Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. PubMed ID: 9716408

A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene. PubMed ID: 9828137

cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. PubMed ID: 9878245

A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease. PubMed ID: 9660799

HRAD1 and MRad1 encode mammalian homologues of the fission yeast rad1+ cell cycle checkpoint control gene. PubMed ID: 9705507

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334