Genular: Defining Cellular Identity and Function

Details for: Rad17

Gene ID: 19356

Symbol: Rad17

Ensembl ID: ENSMUSG00000021635

Description: RAD17 checkpoint clamp loader component

Associated with

Activation of atr in response to replication stress
(R-MMU-176187)
Cell cycle checkpoints
(R-MMU-69620)
Dna double-strand break repair
(R-MMU-5693532)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Hdr through single strand annealing (ssa)
(R-MMU-5685938)
Homology directed repair
(R-MMU-5693538)
Processing of dna double-strand break ends
(R-MMU-5693607)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Rna polymerase ii transcription
(R-MMU-73857)
Transcriptional regulation by tp53
(R-MMU-3700989)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cell cycle
(GO:0007049)
Chromatin binding
(GO:0003682)
Chromosome, telomeric region
(GO:0000781)
Dna clamp loader activity
(GO:0003689)
Dna damage checkpoint signaling
(GO:0000077)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Mitotic dna replication checkpoint signaling
(GO:0033314)
Mitotic intra-s dna damage checkpoint signaling
(GO:0031573)
Multicellular organism development
(GO:0007275)
Negative regulation of dna replication
(GO:0008156)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Rad17 rfc-like complex
(GO:0031389)
Regulation of phosphorylation
(GO:0042325)

Other Information

Proteins

Cell cycle checkpoint protein RAD17

Genular Protein ID: 211606925

Symbol: RAD17_MOUSE

Name: Cell cycle checkpoint protein RAD17

UniProtKB Accession Codes:

Q6NXW6 O88934 O89024

Database IDs:

Citations:

PubMed ID: 10232579

Title: HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma.

PubMed ID: 10232579

PubMed ID: 9933569

Title: Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.

PubMed ID: 9933569

DOI: 10.1006/geno.1998.5642

PubMed ID: 10480350

Title: Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma.

PubMed ID: 10480350

DOI: 10.1007/s004399900067

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11687627

Title: Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.

PubMed ID: 11687627

DOI: 10.1073/pnas.231364598

PubMed ID: 14500819

Title: The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon.

PubMed ID: 14500819

DOI: 10.1093/nar/gkg765

PubMed ID: 15297881

Title: Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination.

PubMed ID: 15297881

DOI: 10.1038/sj.emboj.7600353

PubMed ID: 17376776

Title: Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest.

PubMed ID: 17376776

DOI: 10.1074/jbc.c700019200

Sequence Information:

Length: 688
Mass: 77391
Checksum: 7A950CA8CDDC8732
Sequence:

MSETFLRPKV SSTKVTDWVA PAFDDFEANT AITTITASSL TFSNSSHRRK YLPSTLESNR 
LSARKRGRLS LEQTHGLETS RERLSDNEPW VDKYKPETQH ELAVHKKKIE EVETWLKAQV 
LEVKPKQGGS VLLITGPPGC GKTTTIKILS KELGIQVQEW VNPILPDFQK DDYKELLSLE 
SNFSVVPYQS QIAVFNDFLL RATKYSKLQM LGDDLTTDKK IILVEELPNQ FYRDPNALHE 
ILRKHVQIGR CPLVFIVSDS VSGDNNQRLL FPRNIQEECS VSNISFNPVA PTIMMKFLNR 
IVTIEASKNG EKIIVPNKTS LELLCQGCSG DIRSAINSLQ FSSSKGENSS WSKKKRMSLK 
SDAAISKSKQ KKKHNSTLEN QEIQAIGGKD VSLFLFRALG KILYCKRAPL TELDSPRLPA 
HLSEHDRDTL LVQPEEIVEM SHMPGDFFNL YLHQNYIDFF AEVDDLVPAS EFLSFADILG 
GDWNTRSLLR EYSTSVATRG VMHSNKARGF AHCQGGSSFR PLHKPQWFLI QKKYRENCLA 
AKALFVDFCL PALCLQTQLL PYLALLTIPM RNKAQISFIQ DVGRLPLKRS FGRLKMEALT 
DRELGLIDPD SGDESPHSGG QPAQEAPGEP AQAAQNADPE TWSLPLSQNS GSDLPASQPQ 
PFSSKVDMEE EEEEEEDIII EDYDSEET

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rad17

Associated with

Other Information

HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma. PubMed ID: 10232579

Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene. PubMed ID: 9933569

Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma. PubMed ID: 10480350

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. PubMed ID: 11687627

The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. PubMed ID: 14500819

Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination. PubMed ID: 15297881

Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest. PubMed ID: 17376776