Genular: Defining Cellular Identity and Function

Details for: Rad50

Gene ID: 19360

Symbol: Rad50

Ensembl ID: ENSMUSG00000020380

Description: RAD50 double strand break repair protein

Associated with

Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Dna damage/telomere stress induced senescence
(R-MMU-2559586)
Dna double-strand break repair
(R-MMU-5693532)
Dna double strand break response
(R-MMU-5693606)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdr through homologous recombination (hrr)
(R-MMU-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Hdr through mmej (alt-nhej)
(R-MMU-5685939)
Hdr through single strand annealing (ssa)
(R-MMU-5685938)
Homologous dna pairing and strand exchange
(R-MMU-5693579)
Homology directed repair
(R-MMU-5693538)
Nonhomologous end-joining (nhej)
(R-MMU-5693571)
Presynaptic phase of homologous dna pairing and strand exchange
(R-MMU-5693616)
Processing of dna double-strand break ends
(R-MMU-5693607)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-MMU-5693565)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Resolution of d-loop structures
(R-MMU-5693537)
Resolution of d-loop structures through holliday junction intermediates
(R-MMU-5693568)
Rna polymerase ii transcription
(R-MMU-73857)
Sensing of dna double strand breaks
(R-MMU-5693548)
Transcriptional regulation by tp53
(R-MMU-3700989)
3'-5' exonuclease activity
(GO:0008408)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Brca1-c complex
(GO:0070533)
Cell cycle
(GO:0007049)
Chromatin
(GO:0000785)
Chromosomal region
(GO:0098687)
Chromosome
(GO:0005694)
Chromosome, telomeric region
(GO:0000781)
Chromosome organization
(GO:0051276)
Chromosome organization involved in meiotic cell cycle
(GO:0070192)
Condensed nuclear chromosome
(GO:0000794)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna double-strand break processing
(GO:0000729)
Dna duplex unwinding
(GO:0032508)
Dna helicase activity
(GO:0003678)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Dna strand resection involved in replication fork processing
(GO:0110025)
Double-strand break repair
(GO:0006302)
Double-stranded dna binding
(GO:0003690)
Double-stranded telomeric dna binding
(GO:0003691)
G-quadruplex dna binding
(GO:0051880)
Homologous recombination
(GO:0035825)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Inclusion body
(GO:0016234)
Meiotic cell cycle
(GO:0051321)
Metal ion binding
(GO:0046872)
Mitotic g2/m transition checkpoint
(GO:0044818)
Mre11 complex
(GO:0030870)
Negative regulation of telomere capping
(GO:1904354)
Negative regulation of viral entry into host cell
(GO:0046597)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of protein autophosphorylation
(GO:0031954)
Positive regulation of telomere maintenance
(GO:0032206)
Pronucleus
(GO:0045120)
Protein-containing complex binding
(GO:0044877)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of mitotic recombination
(GO:0000019)
Single-stranded dna endodeoxyribonuclease activity
(GO:0000014)
Single-stranded telomeric dna binding
(GO:0043047)
Site of double-strand break
(GO:0035861)
Telomere maintenance
(GO:0000723)
Telomere maintenance via recombination
(GO:0000722)
Telomere maintenance via telomerase
(GO:0007004)
Telomeric 3' overhang formation
(GO:0031860)

Other Information

Proteins

Q5SV02_MOUSE

Genular Protein ID: 3244644398

Symbol: Q5SV02_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5SV02

Database IDs:

Citations:

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1312
Mass: 153547
Checksum: FD99AF7A0C81D634
Sequence:

MSRIEKMSIL GVRSFGIEDK DKQIISFFSP LTILVGPNGA GKTTIIECLK YICTGDFPPG 
TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GEMVAVHRSM LCSQKNKKTE FKTLEGVITR 
MKHGEKVSLS SKCAEIDREM ISCLGVSKSV LNNVIFCHQE DSNWPLSEGK ALKQKFDEIF 
SATRYIKALD TLRQVRQTQG QKVKECQTEL KYLKQNKEKA CEIRDQITSK EAQLASSQEI 
VRSYEDELEP LKNRLKEIEH NLSKIMKLDN EIKALESRKK QMEKDNSELE QKMEKVFQGT 
DEQLNDLYHN HQRTVREKER RLVDCQRELE KLNKEARLLN QEKAELLVEQ GRLQLQADRH 
QEHIRARDSL IQSLATHLEL DGFERGPFSE RQIKNFHELV KERQEREAKT ASQLLSDLTD 
KEALKQRQLD ELRDRKSGLG RTIELKTEIL TKKQSELRHV RSELQQLEGS SDRILELDQE 
LTKAERELSK AEKNSSIETL KAEVMSLQNE KADLDRSLRK LDQEMEQLNH HTTTRTQMEM 
LTKDKTDKDE QIRKIKSRHS DELTSLLGYF PNKKQLEDWL HSKSKEINQT RDRLAKLNKE 
LASAEQNKNH INNELKKKEE QLSSYEDKLF DVCGSQDLES DLGRLKEEIE KSSKQRAMLA 
GATAVYSQFI TQLTDENQSC CPVCQRVFQT EAELQEVISD LQSKLRLAPD KLKSTESELK 
KKERRRDEML GLVPVRQSII DLKEKEIPEL RNRLQSVNRD IQRLKNDIEE QETLLGTIMP 
EEESAKVCLT DVTIMERFQM ELKDVERKIA QQAAKLQGVD LDRTVQQVNQ EKQEKQHRLD 
TVTSKIELNR KLIQDQQEQI QHLKSKTNEL KSEKLQIATN LQRRQQMEEQ SVELSTEVQS 
LNREIKDAKE QISPLETALE KLQQEKEELI HRKHTSNKMA QDKINDIKEK VKNIHGYMKD 
IENYIQDGKD DYKKQKETEL NGVAVQLNEC EKHREKINKD MGTMRQDIDT QKIQERWLQD 
NLTLRKRRDE LKEVEEERKQ HLKEMGQMQV LQMKNEHQKL EENIDTIKRN HSLALGRQKG 
YEDEILHFKK ELREPQFRDA EEKYREMMIV MRTTELVNKD LDIYYKTLDQ AIMKFHSMKM 
EEINKIIRDL WRSTYRGQDI EYIEIRSDAD ENVSASDKRR NYNYRVVMLK GDTALDMRGR 
CSAGQKVLAS LIIRLALAET FCLNCGILAL DEPTTNLDRE NIESLAHALV EIIKSRSQQR 
NFQLLVITHD EDFVELLGRS EYVEKFYRVK KNMDQCSEIV KCSISSLGSY VH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.