Genular: Defining Cellular Identity and Function

Details for: Rad51

Gene ID: 19361

Symbol: Rad51

Ensembl ID: ENSMUSG00000027323

Description: RAD51 recombinase

Associated with

Dna double-strand break repair
(R-MMU-5693532)
Hdr through homologous recombination (hrr)
(R-MMU-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Hdr through single strand annealing (ssa)
(R-MMU-5685938)
Homologous dna pairing and strand exchange
(R-MMU-5693579)
Homology directed repair
(R-MMU-5693538)
Presynaptic phase of homologous dna pairing and strand exchange
(R-MMU-5693616)
Resolution of d-loop structures
(R-MMU-5693537)
Resolution of d-loop structures through holliday junction intermediates
(R-MMU-5693568)
Atp-dependent activity, acting on dna
(GO:0008094)
Atp-dependent dna damage sensor activity
(GO:0140664)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cellular response to alkaloid
(GO:0071312)
Cellular response to camptothecin
(GO:0072757)
Cellular response to hydroxyurea
(GO:0072711)
Cellular response to ionizing radiation
(GO:0071479)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromosome
(GO:0005694)
Chromosome, telomeric region
(GO:0000781)
Chromosome organization involved in meiotic cell cycle
(GO:0070192)
Condensed chromosome
(GO:0000793)
Condensed nuclear chromosome
(GO:0000794)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna metabolic process
(GO:0006259)
Dna polymerase binding
(GO:0070182)
Dna recombinase assembly
(GO:0000730)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Dna strand exchange activity
(GO:0000150)
Dna strand invasion
(GO:0042148)
Dna unwinding involved in dna replication
(GO:0006268)
Double-strand break repair involved in meiotic recombination
(GO:1990918)
Double-strand break repair via homologous recombination
(GO:0000724)
Double-stranded dna binding
(GO:0003690)
Enzyme binding
(GO:0019899)
Identical protein binding
(GO:0042802)
Interstrand cross-link repair
(GO:0036297)
Lateral element
(GO:0000800)
Male germ cell nucleus
(GO:0001673)
Meiotic cell cycle
(GO:0051321)
Mitochondrion
(GO:0005739)
Mitotic recombination
(GO:0006312)
Mitotic recombination-dependent replication fork processing
(GO:1990426)
Nuclear chromosome
(GO:0000228)
Nuclear ubiquitin ligase complex
(GO:0000152)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Pml body
(GO:0016605)
Positive regulation of dna ligation
(GO:0051106)
Presynaptic intermediate filament cytoskeleton
(GO:0099182)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Reciprocal meiotic recombination
(GO:0007131)
Regulation of dna damage checkpoint
(GO:2000001)
Regulation of double-strand break repair via homologous recombination
(GO:0010569)
Regulation of protein phosphorylation
(GO:0001932)
Replication-born double-strand break repair via sister chromatid exchange
(GO:1990414)
Replication fork processing
(GO:0031297)
Single-stranded dna binding
(GO:0003697)
Single-stranded dna helicase activity
(GO:0017116)
Site of double-strand break
(GO:0035861)
Synaptonemal complex
(GO:0000795)
Telomere maintenance via recombination
(GO:0000722)
Telomere maintenance via telomere lengthening
(GO:0010833)
Telomere organization
(GO:0032200)

Other Information

Proteins

RAD51 homolog A

Genular Protein ID: 1348353928

Symbol: RAD51_MOUSE

Name: RAD51 homolog A

UniProtKB Accession Codes:

Q08297 Q3UAY5

Database IDs:

Citations:

PubMed ID: 8358431

Title: Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA.

PubMed ID: 8358431

DOI: 10.1038/ng0793-239

PubMed ID: 8341671

Title: A mouse homolog of the Escherichia coli recA and Saccharomyces cerevisiae RAD51 genes.

PubMed ID: 8341671

DOI: 10.1073/pnas.90.14.6577

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12531026

Title: Analysis of mouse Rad54 expression and its implications for homologous recombination.

PubMed ID: 12531026

DOI: 10.1016/s1568-7864(02)00110-6

PubMed ID: 15834424

Title: The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination.

PubMed ID: 15834424

DOI: 10.1038/nsmb923

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20976249

Title: Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination.

PubMed ID: 20976249

DOI: 10.1371/journal.pgen.1001160

PubMed ID: 22305526

Title: RAD51 haploinsufficiency causes congenital mirror movements in humans.

PubMed ID: 22305526

DOI: 10.1016/j.ajhg.2011.12.002

PubMed ID: 24108124

Title: FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells.

PubMed ID: 24108124

DOI: 10.1074/jbc.m113.484493

PubMed ID: 30760716

Title: A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.

PubMed ID: 30760716

DOI: 10.1038/s41467-019-08676-2

PubMed ID: 32345962

Title: The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.

PubMed ID: 32345962

DOI: 10.1038/s41467-020-15954-x

PubMed ID: 30272023

Title: Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis.

PubMed ID: 30272023

DOI: 10.1038/s42003-018-0154-z

PubMed ID: 30949703

Title: SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.

PubMed ID: 30949703

DOI: 10.1093/nar/gkz226

PubMed ID: 30746471

Title: SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I.

PubMed ID: 30746471

DOI: 10.1126/sciadv.aau9780

PubMed ID: 32463460

Title: MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis.

PubMed ID: 32463460

DOI: 10.1093/nar/gkaa406

PubMed ID: 35547804

Title: TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required for Male Fertility in Mice.

PubMed ID: 35547804

DOI: 10.3389/fcell.2022.757042

Sequence Information:

Length: 339
Mass: 36971
Checksum: CE631E2C246BA481
Sequence:

MAMQMQLEAS ADTSVEEESF GPQPISRLEQ CGINANDVKK LEEAGYHTVE AVAYAPKKEL 
INIKGISEAK ADKILTEAAK LVPMGFTTAT EFHQRRSEII QITTGSKELD KLLQGGIETG 
SITEMFGEFR TGKTQICHTL AVTCQLPIDR GGGEGKAMYI DTEGTFRPER LLAVAERYGL 
SGSDVLDNVA YARGFNTDHQ TQLLYQASAM MVESRYALLI VDSATALYRT DYSGRGELSA 
RQMHLARFLR MLLRLADEFG VAVVITNQVV AQVDGAAMFA ADPKKPIGGN IIAHASTTRL 
YLRKGRGETR ICKIYDSPCL PEAEAMFAIN ADGVGDAKD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rad51

Associated with

Other Information

Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. PubMed ID: 8358431

A mouse homolog of the Escherichia coli recA and Saccharomyces cerevisiae RAD51 genes. PubMed ID: 8341671

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Analysis of mouse Rad54 expression and its implications for homologous recombination. PubMed ID: 12531026

The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination. PubMed ID: 15834424

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. PubMed ID: 20976249

RAD51 haploinsufficiency causes congenital mirror movements in humans. PubMed ID: 22305526

FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells. PubMed ID: 24108124

A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination. PubMed ID: 30760716

The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells. PubMed ID: 32345962

Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis. PubMed ID: 30272023

SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice. PubMed ID: 30949703

SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I. PubMed ID: 30746471

MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis. PubMed ID: 32463460

TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required for Male Fertility in Mice. PubMed ID: 35547804