Details for: Rag1

Gene ID: 19373

Symbol: Rag1

Ensembl ID: ENSMUSG00000061311

Description: recombination activating 1

Associated with

Other Information

Genular Protein ID: 196975974

Symbol: RAG1_MOUSE

Name: V(D)J recombination-activating protein 1

UniProtKB Accession Codes:

P15919 A2AVN8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 ChEBI 21 DIP 1 DNASU 1 EC 3 EMBL 4 EMDB 14 Ensembl 1 EvolutionaryTrace 1 GO 29 Gene3D 3 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 9 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 25 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PaxDb 1 Pfam 4 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2598259

Title: The V(D)J recombination activating gene, RAG-1.

PubMed ID: 2598259

DOI: 10.1016/0092-8674(89)90760-5

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1547488

Title: RAG-1-deficient mice have no mature B and T lymphocytes.

PubMed ID: 1547488

DOI: 10.1016/0092-8674(92)90030-g

PubMed ID: 8284210

Title: Expression and V(D)J recombination activity of mutated RAG-1 proteins.

PubMed ID: 8284210

DOI: 10.1093/nar/21.24.5644

PubMed ID: 8521468

Title: Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

PubMed ID: 8521468

DOI: 10.1016/0092-8674(95)90116-7

PubMed ID: 9094713

Title: RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination.

PubMed ID: 9094713

DOI: 10.1016/s0092-8674(00)80181-6

PubMed ID: 9184213

Title: Stimulation of V(D)J cleavage by high mobility group proteins.

PubMed ID: 9184213

DOI: 10.1093/emboj/16.10.2665

PubMed ID: 10601032

Title: Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.

PubMed ID: 10601032

DOI: 10.1101/gad.13.23.3059

PubMed ID: 10601033

Title: Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase.

PubMed ID: 10601033

DOI: 10.1101/gad.13.23.3070

PubMed ID: 10678172

Title: Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

PubMed ID: 10678172

DOI: 10.1016/s1097-2765(00)80406-2

PubMed ID: 12629039

Title: The RAG1 N-terminal domain is an E3 ubiquitin ligase.

PubMed ID: 12629039

DOI: 10.1101/gad.1058103

PubMed ID: 14671314

Title: Autoubiquitylation of the V(D)J recombinase protein RAG1.

PubMed ID: 14671314

DOI: 10.1073/pnas.2637012100

PubMed ID: 17028591

Title: Amino acid residues in Rag1 crucial for DNA hairpin formation.

PubMed ID: 17028591

DOI: 10.1038/nsmb1154

PubMed ID: 19524534

Title: H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.

PubMed ID: 19524534

DOI: 10.1016/j.molcel.2009.05.011

PubMed ID: 19118899

Title: Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.

PubMed ID: 19118899

DOI: 10.1016/j.molimm.2008.11.009

PubMed ID: 19448632

Title: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.

PubMed ID: 19448632

DOI: 10.1038/ni.1735

PubMed ID: 20122409

Title: The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining.

PubMed ID: 20122409

DOI: 10.1016/j.molcel.2009.12.035

PubMed ID: 22157821

Title: VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity.

PubMed ID: 22157821

DOI: 10.1038/emboj.2011.455

PubMed ID: 9228952

Title: Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster.

PubMed ID: 9228952

DOI: 10.1038/nsb0797-586

PubMed ID: 19396172

Title: Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.

PubMed ID: 19396172

DOI: 10.1038/nsmb.1593

Sequence Information:

  • Length: 1040
  • Mass: 119185
  • Checksum: 7C2E6AD68DCBA081
  • Sequence:
    • MAASLPSTLS FSSAPDEIQH PQIKFSEWKF KLFRVRSFEK APEEAQKEKD SSEGKPYLEQ 
SPVVPEKPGG QNSILTQRAL KLHPKFSKKF HADGKSSDKA VHQARLRHFC RICGNRFKSD 
GHSRRYPVHG PVDAKTQSLF RKKEKRVTSW PDLIARIFRI DVKADVDSIH PTEFCHDCWS 
IMHRKFSSSH SQVYFPRKVT VEWHPHTPSC DICFTAHRGL KRKRHQPNVQ LSKKLKTVLN 
HARRDRRKRT QARVSSKEVL KKISNCSKIH LSTKLLAVDF PAHFVKSISC QICEHILADP 
VETSCKHLFC RICILRCLKV MGSYCPSCRY PCFPTDLESP VKSFLNILNS LMVKCPAQDC 
NEEVSLEKYN HHVSSHKESK ETLVHINKGG RPRQHLLSLT RRAQKHRLRE LKIQVKEFAD 
KEEGGDVKAV CLTLFLLALR ARNEHRQADE LEAIMQGRGS GLQPAVCLAI RVNTFLSCSQ 
YHKMYRTVKA ITGRQIFQPL HALRNAEKVL LPGYHPFEWQ PPLKNVSSRT DVGIIDGLSG 
LASSVDEYPV DTIAKRFRYD SALVSALMDM EEDILEGMRS QDLDDYLNGP FTVVVKESCD 
GMGDVSEKHG SGPAVPEKAV RFSFTVMRIT IEHGSQNVKV FEEPKPNSEL CCKPLCLMLA 
DESDHETLTA ILSPLIAERE AMKSSELTLE MGGIPRTFKF IFRGTGYDEK LVREVEGLEA 
SGSVYICTLC DTTRLEASQN LVFHSITRSH AENLQRYEVW RSNPYHESVE ELRDRVKGVS 
AKPFIETVPS IDALHCDIGN AAEFYKIFQL EIGEVYKHPN ASKEERKRWQ ATLDKHLRKR 
MNLKPIMRMN GNFARKLMTQ ETVDAVCELI PSEERHEALR ELMDLYLKMK PVWRSSCPAK 
ECPESLCQYS FNSQRFAELL STKFKYRYEG KITNYFHKTL AHVPEIIERD GSIGAWASEG 
NESGNKLFRR FRKMNARQSK CYEMEDVLKH HWLYTSKYLQ KFMNAHNALK SSGFTMNSKE 
TLGDPLGIED SLESQDSMEF

Genular Protein ID: 272612137

Symbol: Q3TR87_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TR87

Database IDs:

AGR 1 ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 ChEBI 2 DNASU 1 EC 1 EMBL 2 GO 6 Genevisible 1 InterPro 2 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 RefSeq 1 SAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 140
  • Mass: 15891
  • Checksum: A4FF6FB3F9D79FE3
  • Sequence:
    • MAASLPSTLS FSSAPDEIQH PQIKFSEWKF KLFRVRSFEK APEEAQKEKD SSEGKPYLEQ 
SPVVPEKPGG QNSILTQRAL KLHPKFSKKF HADGESSDKA VHQARLRHFC RICGNRFKSD 
GHSRRYPVHG PVDAKTQSLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.