Details for: Rag2
Associated with
Other Information
Genular Protein ID: 3285014377
Symbol: RAG2_MOUSE
Name: V(D)J recombination-activating protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2360047
Title: RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination.
PubMed ID: 2360047
PubMed ID: 1547487
Title: RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.
PubMed ID: 1547487
PubMed ID: 8521468
Title: Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.
PubMed ID: 8521468
PubMed ID: 9094713
Title: RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination.
PubMed ID: 9094713
PubMed ID: 9184213
Title: Stimulation of V(D)J cleavage by high mobility group proteins.
PubMed ID: 9184213
PubMed ID: 10601032
Title: Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.
PubMed ID: 10601032
PubMed ID: 16111638
Title: A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination.
PubMed ID: 16111638
PubMed ID: 18033247
Title: RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.
PubMed ID: 18033247
DOI: 10.1038/nature06431
PubMed ID: 18724932
Title: Trex1 prevents cell-intrinsic initiation of autoimmunity.
PubMed ID: 18724932
PubMed ID: 19524534
Title: H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.
PubMed ID: 19524534
PubMed ID: 19448632
Title: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.
PubMed ID: 19448632
DOI: 10.1038/ni.1735
PubMed ID: 19396172
Title: Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.
PubMed ID: 19396172
DOI: 10.1038/nsmb.1593
PubMed ID: 15964836
Title: A PHD finger motif in the C terminus of RAG2 modulates recombination activity.
PubMed ID: 15964836
PubMed ID: 18025461
Title: The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2.
PubMed ID: 18025461
Sequence Information:
- Length: 527
- Mass: 59074
- Checksum: 51086F95A4A664A7
- Sequence:
MSLQMVTVGH NIALIQPGFS LMNFDGQVFF FGQKGWPKRS CPTGVFHFDI KQNHLKLKPA IFSKDSCYLP PLRYPATCSY KGSIDSDKHQ YIIHGGKTPN NELSDKIYIM SVACKNNKKV TFRCTEKDLV GDVPEPRYGH SIDVVYSRGK SMGVLFGGRS YMPSTQRTTE KWNSVADCLP HVFLIDFEFG CATSYILPEL QDGLSFHVSI ARNDTVYILG GHSLASNIRP ANLYRIRVDL PLGTPAVNCT VLPGGISVSS AILTQTNNDE FVIVGGYQLE NQKRMVCSLV SLGDNTIEIS EMETPDWTSD IKHSKIWFGS NMGNGTIFLG IPGDNKQAMS EAFYFYTLRC SEEDLSEDQK IVSNSQTSTE DPGDSTPFED SEEFCFSAEA TSFDGDDEFD TYNEDDEDDE SVTGYWITCC PTCDVDINTW VPFYSTELNK PAMIYCSHGD GHWVHAQCMD LEERTLIHLS EGSNKYYCNE HVQIARALQT PKRNPPLQKP PMKSLHKKGS GKVLTPAKKS FLRRLFD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.