Genular: Defining Cellular Identity and Function

Details for: Rag2

Gene ID: 19374

Symbol: Rag2

Ensembl ID: ENSMUSG00000032864

Description: recombination activating gene 2

Associated with

B cell differentiation
(GO:0030183)
B cell homeostatic proliferation
(GO:0002358)
B cell lineage commitment
(GO:0002326)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Defense response to bacterium
(GO:0042742)
Dn2 thymocyte differentiation
(GO:1904155)
Dna binding
(GO:0003677)
Dna recombinase complex
(GO:0097519)
Dna recombination
(GO:0006310)
Mature b cell differentiation involved in immune response
(GO:0002313)
Metal ion binding
(GO:0046872)
Methylated histone binding
(GO:0035064)
Negative regulation of t cell differentiation in thymus
(GO:0033085)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Organ growth
(GO:0035265)
Phosphatidylinositol-3,4,5-trisphosphate binding
(GO:0005547)
Phosphatidylinositol-3,4-bisphosphate binding
(GO:0043325)
Phosphatidylinositol-3,5-bisphosphate binding
(GO:0080025)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Phosphatidylinositol binding
(GO:0035091)
Positive regulation of organ growth
(GO:0046622)
Pre-b cell allelic exclusion
(GO:0002331)
Protein binding
(GO:0005515)
Sequence-specific dna binding
(GO:0043565)
T cell differentiation
(GO:0030217)
T cell differentiation in thymus
(GO:0033077)
T cell lineage commitment
(GO:0002360)
V(d)j recombination
(GO:0033151)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

V(D)J recombination-activating protein 2

Genular Protein ID: 3285014377

Symbol: RAG2_MOUSE

Name: V(D)J recombination-activating protein 2

UniProtKB Accession Codes:

P21784

Database IDs:

Citations:

PubMed ID: 2360047

Title: RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination.

PubMed ID: 2360047

DOI: 10.1126/science.2360047

PubMed ID: 1547487

Title: RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.

PubMed ID: 1547487

DOI: 10.1016/0092-8674(92)90029-c

PubMed ID: 8521468

Title: Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

PubMed ID: 8521468

DOI: 10.1016/0092-8674(95)90116-7

PubMed ID: 9094713

Title: RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination.

PubMed ID: 9094713

DOI: 10.1016/s0092-8674(00)80181-6

PubMed ID: 9184213

Title: Stimulation of V(D)J cleavage by high mobility group proteins.

PubMed ID: 9184213

DOI: 10.1093/emboj/16.10.2665

PubMed ID: 10601032

Title: Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.

PubMed ID: 10601032

DOI: 10.1101/gad.13.23.3059

PubMed ID: 16111638

Title: A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination.

PubMed ID: 16111638

DOI: 10.1016/j.immuni.2005.07.004

PubMed ID: 18033247

Title: RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.

PubMed ID: 18033247

DOI: 10.1038/nature06431

PubMed ID: 18724932

Title: Trex1 prevents cell-intrinsic initiation of autoimmunity.

PubMed ID: 18724932

DOI: 10.1016/j.cell.2008.06.032

PubMed ID: 19524534

Title: H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.

PubMed ID: 19524534

DOI: 10.1016/j.molcel.2009.05.011

PubMed ID: 19448632

Title: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.

PubMed ID: 19448632

DOI: 10.1038/ni.1735

PubMed ID: 19396172

Title: Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.

PubMed ID: 19396172

DOI: 10.1038/nsmb.1593

PubMed ID: 15964836

Title: A PHD finger motif in the C terminus of RAG2 modulates recombination activity.

PubMed ID: 15964836

DOI: 10.1074/jbc.m504731200

PubMed ID: 18025461

Title: The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2.

PubMed ID: 18025461

DOI: 10.1073/pnas.0709170104

Sequence Information:

Length: 527
Mass: 59074
Checksum: 51086F95A4A664A7
Sequence:

MSLQMVTVGH NIALIQPGFS LMNFDGQVFF FGQKGWPKRS CPTGVFHFDI KQNHLKLKPA 
IFSKDSCYLP PLRYPATCSY KGSIDSDKHQ YIIHGGKTPN NELSDKIYIM SVACKNNKKV 
TFRCTEKDLV GDVPEPRYGH SIDVVYSRGK SMGVLFGGRS YMPSTQRTTE KWNSVADCLP 
HVFLIDFEFG CATSYILPEL QDGLSFHVSI ARNDTVYILG GHSLASNIRP ANLYRIRVDL 
PLGTPAVNCT VLPGGISVSS AILTQTNNDE FVIVGGYQLE NQKRMVCSLV SLGDNTIEIS 
EMETPDWTSD IKHSKIWFGS NMGNGTIFLG IPGDNKQAMS EAFYFYTLRC SEEDLSEDQK 
IVSNSQTSTE DPGDSTPFED SEEFCFSAEA TSFDGDDEFD TYNEDDEDDE SVTGYWITCC 
PTCDVDINTW VPFYSTELNK PAMIYCSHGD GHWVHAQCMD LEERTLIHLS EGSNKYYCNE 
HVQIARALQT PKRNPPLQKP PMKSLHKKGS GKVLTPAKKS FLRRLFD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rag2

Associated with

Other Information

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. PubMed ID: 2360047

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. PubMed ID: 1547487

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. PubMed ID: 8521468

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. PubMed ID: 9094713

Stimulation of V(D)J cleavage by high mobility group proteins. PubMed ID: 9184213

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. PubMed ID: 10601032

A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination. PubMed ID: 16111638

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. PubMed ID: 18033247

Trex1 prevents cell-intrinsic initiation of autoimmunity. PubMed ID: 18724932

H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations. PubMed ID: 19524534

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. PubMed ID: 19448632

Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. PubMed ID: 19396172

A PHD finger motif in the C terminus of RAG2 modulates recombination activity. PubMed ID: 15964836

The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. PubMed ID: 18025461