Genular: Defining Cellular Identity and Function

Details for: Aldh1a2

Gene ID: 19378

Symbol: Aldh1a2

Ensembl ID: ENSMUSG00000013584

Description: aldehyde dehydrogenase family 1, subfamily A2

Associated with

Ra biosynthesis pathway
(R-MMU-5365859)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by retinoic acid
(R-MMU-5362517)
Signal transduction
(R-MMU-162582)
3-chloroallyl aldehyde dehydrogenase activity
(GO:0004028)
9-cis-retinoic acid biosynthetic process
(GO:0042904)
Aldehyde dehydrogenase (nad+) activity
(GO:0004029)
Anterior/posterior pattern specification
(GO:0009952)
Blood vessel development
(GO:0001568)
Camera-type eye development
(GO:0043010)
Cardiac muscle tissue development
(GO:0048738)
Cell population proliferation
(GO:0008283)
Cellular response to retinoic acid
(GO:0071300)
Cytoplasm
(GO:0005737)
Determination of bilateral symmetry
(GO:0009855)
Embryonic camera-type eye development
(GO:0031076)
Embryonic digestive tract development
(GO:0048566)
Embryonic forelimb morphogenesis
(GO:0035115)
Embryonic limb morphogenesis
(GO:0030326)
Face development
(GO:0060324)
Forebrain development
(GO:0030900)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Heart morphogenesis
(GO:0003007)
Hindbrain development
(GO:0030902)
Lipid metabolic process
(GO:0006629)
Lung development
(GO:0030324)
Morphogenesis of embryonic epithelium
(GO:0016331)
Negative regulation of cell population proliferation
(GO:0008285)
Neural crest cell development
(GO:0014032)
Neural tube development
(GO:0021915)
Neuron differentiation
(GO:0030182)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, nad or nadp as acceptor
(GO:0016620)
Pancreas development
(GO:0031016)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Protein homotetramerization
(GO:0051289)
Proximal/distal pattern formation
(GO:0009954)
Regulation of vascular endothelial cell proliferation
(GO:1905562)
Response to cytokine
(GO:0034097)
Response to retinoic acid
(GO:0032526)
Retinal binding
(GO:0016918)
Retinal dehydrogenase activity
(GO:0001758)
Retinal metabolic process
(GO:0042574)
Retinoic acid biosynthetic process
(GO:0002138)
Retinoic acid metabolic process
(GO:0042573)
Retinoic acid receptor signaling pathway
(GO:0048384)
Retinoic acid receptor signaling pathway involved in somitogenesis
(GO:0090242)
Retinoid metabolic process
(GO:0001523)
Ureter maturation
(GO:0035799)

Other Information

Proteins

Retinal dehydrogenase 2

Genular Protein ID: 3208139178

Symbol: AL1A2_MOUSE

Name: Retinal dehydrogenase 2

UniProtKB Accession Codes:

Q62148 Q6DI79

Database IDs:

Citations:

PubMed ID: 8797830

Title: Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase.

PubMed ID: 8797830

DOI: 10.1111/j.1432-1033.1996.0015h.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9106168

Title: Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development.

PubMed ID: 9106168

DOI: 10.1016/s0925-4773(96)00653-3

PubMed ID: 15911617

Title: Metabolism and transactivation activity of 13,14-dihydroretinoic acid.

PubMed ID: 15911617

DOI: 10.1074/jbc.m503520200

PubMed ID: 22075477

Title: Initiating meiosis: the case for retinoic acid.

PubMed ID: 22075477

DOI: 10.1095/biolreprod.111.096610

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 518
Mass: 56626
Checksum: 2BC35B5C90046ABC
Sequence:

MTSSEIAMPG EVKADPAALM ASLQLLPSPT PNLEIKYTKI FINNEWQNSE SGRVFPVCNP 
ATGEQVCEVQ EADKVDIDKA VQAARLAFSL GSVWRRMDAS ERGRLLDKLA DLVERDRATL 
ATMESLNGGK PFLQAFYIDL QGVIKTLRYY AGWADKIHGM TIPVDGDYFT FTRHEPIGVC 
GQIIPWNFPL LMFTWKIAPA LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVVNILP 
GYGPTAGAAI ASHIGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD 
LDYAVEQAHQ GVFFNQGQCC TAGSRIFVEE SIYEEFVKRS VERAKRRIVG SPFDPTTEQG 
PQIDKKQYNK VLELIQSGVA EGAKLECGGK GLGRKGFFIE PTVFSNVTDD MRIAKEEIFG 
PVQEILRFKT MDEVIERANN SDFGLVAAVF TNDINKALMV SSAMQAGTVW INCYNALNAQ 
SPFGGFKMSG NGREMGEFGL REYSEVKTVT VKIPQKNS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Aldh1a2

Associated with

Other Information

Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase. PubMed ID: 8797830

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development. PubMed ID: 9106168

Metabolism and transactivation activity of 13,14-dihydroretinoic acid. PubMed ID: 15911617

Initiating meiosis: the case for retinoic acid. PubMed ID: 22075477

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079