Genular: Defining Cellular Identity and Function

Details for: Ran

Gene ID: 19384

Symbol: Ran

Ensembl ID: ENSMUSG00000029430

Description: RAN, member RAS oncogene family

Associated with

Cell cycle, mitotic
(R-MMU-69278)
Gene expression (transcription)
(R-MMU-74160)
Gene silencing by rna
(R-MMU-211000)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of steroids
(R-MMU-8957322)
Mitotic anaphase
(R-MMU-68882)
Mitotic metaphase and anaphase
(R-MMU-2555396)
M phase
(R-MMU-68886)
Nuclear envelope (ne) reassembly
(R-MMU-2995410)
Postmitotic nuclear pore complex (npc) reformation
(R-MMU-9615933)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-MMU-1655829)
Transcriptional regulation by small rnas
(R-MMU-5578749)
Actin cytoskeleton organization
(GO:0030036)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Centriole
(GO:0005814)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Dynein intermediate chain binding
(GO:0045505)
Gdp binding
(GO:0019003)
G protein activity
(GO:0003925)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Gtp metabolic process
(GO:0046039)
Hydrolase activity
(GO:0016787)
Importin-alpha family protein binding
(GO:0061676)
Magnesium ion binding
(GO:0000287)
Male germ cell nucleus
(GO:0001673)
Manchette
(GO:0002177)
Metal ion binding
(GO:0046872)
Midbody
(GO:0030496)
Mitotic sister chromatid segregation
(GO:0000070)
Nuclear envelope
(GO:0005635)
Nuclear pore
(GO:0005643)
Nucleocytoplasmic transport
(GO:0006913)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein import into nucleus
(GO:0042307)
Pre-mirna binding
(GO:0070883)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein-containing complex localization
(GO:0031503)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein export from nucleus
(GO:0006611)
Protein heterodimerization activity
(GO:0046982)
Protein import into nucleus
(GO:0006606)
Protein localization
(GO:0008104)
Protein localization to nucleolus
(GO:1902570)
Protein transport
(GO:0015031)
Recycling endosome
(GO:0055037)
Ribosomal large subunit export from nucleus
(GO:0000055)
Ribosomal small subunit export from nucleus
(GO:0000056)
Ribosomal subunit export from nucleus
(GO:0000054)
Rna nuclear export complex
(GO:0042565)
Snrna import into nucleus
(GO:0061015)
Sperm flagellum
(GO:0036126)

Other Information

Proteins

GTP-binding nuclear protein Ran

Genular Protein ID: 3704926844

Symbol: RAN_MOUSE

Name: GTP-binding nuclear protein Ran

UniProtKB Accession Codes:

P62827 P17080 P28746 P28747 Q3U954 Q811M2 Q86V08 Q9CSP3 Q9CWI7 Q9CZA2 Q9UDJ5 Q9UEU9

Database IDs:

Citations:

PubMed ID: 7849398

Title: Tissue-specific expression of Ran isoforms in the mouse.

PubMed ID: 7849398

DOI: 10.1007/bf00411457

PubMed ID: 8890215

Title: Restoration of lipopolysaccharide-mediated B-cell response after expression of a cDNA encoding a GTP-binding protein.

PubMed ID: 8890215

DOI: 10.1128/iai.64.11.4612-4617.1996

PubMed ID: 10500213

Title: Lps(d)/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses.

PubMed ID: 10500213

DOI: 10.1073/pnas.96.20.11543

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1555775

Title: The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach.

PubMed ID: 1555775

DOI: 10.1016/0378-1119(92)90387-5

PubMed ID: 7891706

Title: Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.

PubMed ID: 7891706

DOI: 10.1128/mcb.15.4.2117

PubMed ID: 9428644

Title: RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors.

PubMed ID: 9428644

DOI: 10.1016/s0014-5793(97)01467-1

PubMed ID: 10811801

Title: The mammalian Mog1 protein is a guanine nucleotide release factor for Ran.

PubMed ID: 10811801

DOI: 10.1074/jbc.c000252200

PubMed ID: 18347012

Title: RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules.

PubMed ID: 18347012

DOI: 10.1074/jbc.m709397200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 26304119

Title: MYCBP2 is a guanosine exchange factor for Ran protein and determines its localization in neurons of dorsal root ganglia.

PubMed ID: 26304119

DOI: 10.1074/jbc.m115.646901

PubMed ID: 25946333

Title: The inner nuclear membrane protein Nemp1 is a new type of RanGTP-binding protein in eukaryotes.

PubMed ID: 25946333

DOI: 10.1371/journal.pone.0127271

Sequence Information:

Length: 216
Mass: 24423
Checksum: D5C9B7275C34BCE0
Sequence:

MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL VFHTNRGPIK 
FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN VPNWHRDLVR VCENIPIVLC 
GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS AKSNYNFEKP FLWLARKLIG DPNLEFVAMP 
ALAPPEVVMD PALAAQYEHD LEVAQTTALP DEDDDL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ran

Associated with

Other Information

Tissue-specific expression of Ran isoforms in the mouse. PubMed ID: 7849398

Restoration of lipopolysaccharide-mediated B-cell response after expression of a cDNA encoding a GTP-binding protein. PubMed ID: 8890215

Lps(d)/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses. PubMed ID: 10500213

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. PubMed ID: 1555775

Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. PubMed ID: 7891706

RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors. PubMed ID: 9428644

The mammalian Mog1 protein is a guanine nucleotide release factor for Ran. PubMed ID: 10811801

RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. PubMed ID: 18347012

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

MYCBP2 is a guanosine exchange factor for Ran protein and determines its localization in neurons of dorsal root ganglia. PubMed ID: 26304119

The inner nuclear membrane protein Nemp1 is a new type of RanGTP-binding protein in eukaryotes. PubMed ID: 25946333