Rara | ENSMUSG00000037992 | NCBI 19401

Details for: Rara

Gene ID: 19401

Symbol: Rara

Ensembl ID: ENSMUSG00000037992

Description: retinoic acid receptor, alpha

Associated with

Developmental biology
(R-MMU-1266738)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Nuclear receptor transcription pathway
(R-MMU-383280)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by retinoic acid
(R-MMU-5362517)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Transcriptional regulation of granulopoiesis
(R-MMU-9616222)
Alpha-actinin binding
(GO:0051393)
Apoptotic cell clearance
(GO:0043277)
Cell differentiation
(GO:0030154)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription repressor activity
(GO:0001217)
Dna binding
(GO:0003677)
Embryonic camera-type eye development
(GO:0031076)
Enzyme binding
(GO:0019899)
Face development
(GO:0060324)
Germ cell development
(GO:0007281)
Glandular epithelial cell development
(GO:0002068)
Growth plate cartilage development
(GO:0003417)
Heterocyclic compound binding
(GO:1901363)
Histone deacetylase binding
(GO:0042826)
Hormone-mediated signaling pathway
(GO:0009755)
Limb development
(GO:0060173)
Male gonad development
(GO:0008584)
Metal ion binding
(GO:0046872)
Mrna 5'-utr binding
(GO:0048027)
Mrna regulatory element binding translation repressor activity
(GO:0000900)
Mrna transcription by rna polymerase ii
(GO:0042789)
Multicellular organism growth
(GO:0035264)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of granulocyte differentiation
(GO:0030853)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of translation
(GO:0017148)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Negative regulation of type ii interferon production
(GO:0032689)
Neural tube closure
(GO:0001843)
Nuclear receptor activity
(GO:0004879)
Positive regulation of binding
(GO:0051099)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of interleukin-5 production
(GO:0032754)
Positive regulation of interleukin-13 production
(GO:0032736)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of t-helper 2 cell differentiation
(GO:0045630)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase a binding
(GO:0051018)
Protein kinase b binding
(GO:0043422)
Protein phosphorylation
(GO:0006468)
Regulation of apoptotic process
(GO:0042981)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of granulocyte differentiation
(GO:0030852)
Regulation of myelination
(GO:0031641)
Regulation of synaptic plasticity
(GO:0048167)
Response to ethanol
(GO:0045471)
Response to retinoic acid
(GO:0032526)
Retinoic acid-responsive element binding
(GO:0044323)
Retinoic acid binding
(GO:0001972)
Retinoic acid receptor signaling pathway
(GO:0048384)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Sertoli cell fate commitment
(GO:0060010)
Signaling receptor binding
(GO:0005102)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Ureteric bud development
(GO:0001657)
Ventricular cardiac muscle cell differentiation
(GO:0055012)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Retinoic acid receptor alpha
Q3U5E7_MOUSE

Genular Protein ID: 3020299821

Symbol: RARA_MOUSE

Name: Retinoic acid receptor alpha

UniProtKB Accession Codes:

P11416 P22603

Database IDs:

Citations:

PubMed ID: 2544807

Title: Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin.

PubMed ID: 2544807

DOI: 10.1038/339714a0

PubMed ID: 8383767

Title: Cloning of several genes coding for retinoic acid nuclear receptors in the mouse embryonal carcinoma cell line PCC7-MZ1.

PubMed ID: 8383767

DOI: 10.3109/10799899309073687

PubMed ID: 1846598

Title: Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.

PubMed ID: 1846598

DOI: 10.1002/j.1460-2075.1991.tb07921.x

PubMed ID: 1320576

Title: Retinoic acid resistance of the variant embryonal carcinoma cell line RAC65 is caused by expression of a truncated RAR alpha.

PubMed ID: 1320576

DOI: 10.1111/j.1432-0436.1992.tb00766.x

PubMed ID: 2174108

Title: A dominant negative mutation of the alpha retinoic acid receptor gene in a retinoic acid-nonresponsive embryonal carcinoma cell.

PubMed ID: 2174108

DOI: 10.1128/mcb.10.12.6445-6453.1990

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17205979

Title: Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function.

PubMed ID: 17205979

DOI: 10.1074/mcp.m600223-mcp200

PubMed ID: 9230306

Title: Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7.

PubMed ID: 9230306

DOI: 10.1016/s0092-8674(00)80317-7

PubMed ID: 9192892

Title: The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.

PubMed ID: 9192892

DOI: 10.1038/42652

PubMed ID: 10660575

Title: Follicle-stimulating hormone inhibits all-trans-retinoic acid-induced retinoic acid receptor alpha nuclear localization and transcriptional activation in mouse Sertoli cell lines.

PubMed ID: 10660575

DOI: 10.1074/jbc.275.6.4145

PubMed ID: 10788465

Title: Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR.

PubMed ID: 10788465

DOI: 10.1074/jbc.275.18.13510

PubMed ID: 12079996

Title: Positive regulation of retinoic acid receptor alpha by protein kinase C and mitogen-activated protein kinase in sertoli cells.

PubMed ID: 12079996

DOI: 10.1095/biolreprod67.1.29

PubMed ID: 15901285

Title: Male sterility in mice lacking retinoic acid receptor alpha involves specific abnormalities in spermiogenesis.

PubMed ID: 15901285

DOI: 10.1111/j.1432-0436.2005.00018.x

PubMed ID: 17905941

Title: Potential functions of retinoic acid receptor A in Sertoli cells and germ cells during spermatogenesis.

PubMed ID: 17905941

DOI: 10.1196/annals.1411.008

PubMed ID: 19389355

Title: Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PubMed ID: 19389355

DOI: 10.1016/j.ydbio.2009.01.031

PubMed ID: 19078967

Title: A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters.

PubMed ID: 19078967

DOI: 10.1038/emboj.2008.256

PubMed ID: 20078863

Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.

PubMed ID: 20078863

DOI: 10.1186/1471-2199-11-3

Sequence Information:

Length: 462
Mass: 50735
Checksum: 726F7799633A85AD
Sequence:

MASNSSSCPT PGGGHLNGYP VPPYAFFFPP MLGGLSPPGA LTSLQHQLPV SGYSTPSPAT 
IETQSSSSEE IVPSPPSPPP LPRIYKPCFV CQDKSSGYHY GVSACEGCKG FFRRSIQKNM 
VYTCHRDKNC IINKVTRNRC QYCRLQKCFD VGMSKESVRN DRNKKKKEAP KPECSESYTL 
TPEVGELIEK VRKAHQETFP ALCQLGKYTT NNSSEQRVSL DIDLWDKFSE LSTKCIIKTV 
EFAKQLPGFT TLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA 
GFGPLTDLVF AFANQLLPLE MDDAETGLLS AICLICGDRQ DLEQPDKVDM LQEPLLEALK 
VYVRKRRPSR PHMFPKMLMK ITDLRSISAK GAERVITLKM EIPGSMPPLI QEMLENSEGL 
DTLSGQSGGG TRDGGGLAPP PGSCSPSLSP SSHRSSPATQ SP

Genular Protein ID: 1028198925

Symbol: Q3U5E7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U5E7

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 343
Mass: 38205
Checksum: C75E02F31BEB77B1
Sequence:

MVYTCHRDKN CIINKVTRNR CQYCRLQKCF DVGMSKESVR NDRNKKKKEA PKPECSESYT 
LTPEVGELIE KVRKAHQETF PALCQLGKYT TNNSSEQRVS LDIDLWDKFS ELSTKCIIKT 
VEFAKQLPGF TTLTIADQIT LLKAACLDIL ILRICTRYTP EQDTMTFSDG LTLNRTQMHN 
AGFGPLTDLV FAFANQLLPL EMDDAETGLL SAICLICGDR QDLEQPDKVD MLQEPLLEAL 
KVYVRKRRPS RPHMFPKMLM KITDLRSISA KGAERVITLK MEIPGSMPPL IQEMLENSEG 
LDTLSGQSGG GTRDGGGLAP PPGSCSPSLS PSSHRSSPAT QSP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rara

Associated with

Other Information

Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. PubMed ID: 2544807

Cloning of several genes coding for retinoic acid nuclear receptors in the mouse embryonal carcinoma cell line PCC7-MZ1. PubMed ID: 8383767

Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid. PubMed ID: 1846598

Retinoic acid resistance of the variant embryonal carcinoma cell line RAC65 is caused by expression of a truncated RAR alpha. PubMed ID: 1320576

A dominant negative mutation of the alpha retinoic acid receptor gene in a retinoic acid-nonresponsive embryonal carcinoma cell. PubMed ID: 2174108

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function. PubMed ID: 17205979

Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. PubMed ID: 9230306

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. PubMed ID: 9192892

Follicle-stimulating hormone inhibits all-trans-retinoic acid-induced retinoic acid receptor alpha nuclear localization and transcriptional activation in mouse Sertoli cell lines. PubMed ID: 10660575

Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. PubMed ID: 10788465

Positive regulation of retinoic acid receptor alpha by protein kinase C and mitogen-activated protein kinase in sertoli cells. PubMed ID: 12079996

Male sterility in mice lacking retinoic acid receptor alpha involves specific abnormalities in spermiogenesis. PubMed ID: 15901285

Potential functions of retinoic acid receptor A in Sertoli cells and germ cells during spermatogenesis. PubMed ID: 17905941

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. PubMed ID: 19389355

A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters. PubMed ID: 19078967

The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR. PubMed ID: 20078863

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073