Genular: Defining Cellular Identity and Function

Details for: Rasgrp1

Gene ID: 19419

Symbol: Rasgrp1

Ensembl ID: ENSMUSG00000027347

Description: RAS guanyl releasing protein 1

Associated with

Activation of ras in b cells
(R-MMU-1169092)
Adaptive immune system
(R-MMU-1280218)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Integrin signaling
(R-MMU-354192)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet aggregation (plug formation)
(R-MMU-76009)
Raf/map kinase cascade
(R-MMU-5673001)
Rap1 signalling
(R-MMU-392517)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signal transduction
(R-MMU-162582)
Activation of gtpase activity
(GO:0090630)
B cell activation
(GO:0042113)
B cell proliferation
(GO:0042100)
Calcium ion binding
(GO:0005509)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Diacylglycerol binding
(GO:0019992)
Endoplasmic reticulum
(GO:0005783)
Golgi apparatus
(GO:0005794)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Identical protein binding
(GO:0042802)
Inflammatory response to antigenic stimulus
(GO:0002437)
Mast cell cytokine production
(GO:0032762)
Mast cell degranulation
(GO:0043303)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Natural killer cell activation
(GO:0030101)
Phosphatidylcholine binding
(GO:0031210)
Plasma membrane
(GO:0005886)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of granulocyte macrophage colony-stimulating factor production
(GO:0032725)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of natural killer cell activation
(GO:0032816)
Positive regulation of natural killer cell differentiation
(GO:0032825)
Positive regulation of natural killer cell mediated cytotoxicity
(GO:0045954)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of ras protein signal transduction
(GO:0046579)
Positive regulation of t cell differentiation in thymus
(GO:0033089)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type ii interferon production
(GO:0032729)
Ras protein signal transduction
(GO:0007265)
Regulation of erk1 and erk2 cascade
(GO:0070372)
Regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051896)
Secretory granule localization
(GO:0032252)
Small gtpase-mediated signal transduction
(GO:0007264)
T cell activation
(GO:0042110)
T cell proliferation
(GO:0042098)
Vesicle transport along microtubule
(GO:0047496)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

RAS guanyl-releasing protein 1

Genular Protein ID: 409898877

Symbol: GRP1_MOUSE

Name: RAS guanyl-releasing protein 1

UniProtKB Accession Codes:

Q9Z1S3 Q3URH0 Q3V401 Q8BQP6

Database IDs:

Citations:

PubMed ID: 10087292

Title: RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions.

PubMed ID: 10087292

DOI: 10.1007/s003359901001

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9819387

Title: Regulation of RasGRP via a phorbol ester-responsive C1 domain.

PubMed ID: 9819387

DOI: 10.1128/mcb.18.12.6995

PubMed ID: 11017103

Title: RasGRP is essential for mouse thymocyte differentiation and TCR signaling.

PubMed ID: 11017103

DOI: 10.1038/79766

PubMed ID: 12433368

Title: RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation.

PubMed ID: 12433368

DOI: 10.1016/s1074-7613(02)00451-x

PubMed ID: 12932358

Title: Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.

PubMed ID: 12932358

DOI: 10.1016/s1074-7613(03)00209-7

PubMed ID: 22808526

Title:

PubMed ID: 22808526

DOI: 10.1016/j.immuni.2012.05.007

PubMed ID: 14532295

Title: RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes.

PubMed ID: 14532295

DOI: 10.1074/jbc.m308240200

PubMed ID: 12538669

Title: Transgenic expression of RasGRP1 induces the maturation of double-negative thymocytes and enhances the production of CD8 single-positive thymocytes.

PubMed ID: 12538669

DOI: 10.4049/jimmunol.170.3.1141

PubMed ID: 12845332

Title: Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.

PubMed ID: 12845332

DOI: 10.1038/nature01806

PubMed ID: 14970203

Title: RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.

PubMed ID: 14970203

DOI: 10.1074/jbc.m314273200

PubMed ID: 16301621

Title: RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling.

PubMed ID: 16301621

DOI: 10.4049/jimmunol.175.11.7179

PubMed ID: 15829980

Title: Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors.

PubMed ID: 15829980

DOI: 10.1038/sj.onc.1208334

PubMed ID: 16849453

Title: RasGRP1 transmits prodifferentiation TCR signaling that is crucial for CD4 T cell development.

PubMed ID: 16849453

DOI: 10.4049/jimmunol.177.3.1470

PubMed ID: 17523924

Title: Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.

PubMed ID: 17523924

DOI: 10.1042/bj20070294

PubMed ID: 17210708

Title: Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin.

PubMed ID: 17210708

DOI: 10.1158/0008-5472.can-06-3080

PubMed ID: 17190838

Title: An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response.

PubMed ID: 17190838

DOI: 10.1084/jem.20061598

PubMed ID: 17675473

Title: Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion.

PubMed ID: 17675473

DOI: 10.4049/jimmunol.179.4.2143

PubMed ID: 17567957

Title: Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane.

PubMed ID: 17567957

DOI: 10.1091/mbc.e06-10-0932

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 795
Mass: 90304
Checksum: E2096D985DFB79A0
Sequence:

MGTLGKAREA PRKPCHGSRA GPKARLEAKS TNSPLPAQPS LAQITQFRMM VSLGHLAKGA 
SLDDLIDSCI QSFDADGNLC RNNQLLQVML TMHRIIISSA ELLQKVMNLY KDALEKNSPG 
VCLKICYFVR YWITEFWIMF KMDASLTSTM EEFQDLVKAN GEETHCHLID TTQINSRDWS 
RKLTQRIKSN TSKKRKVSLL FDHLEPEELS EHLTYLEFKS FRRISFSDYQ NYLVNSCVKE 
NPTMERSIAL CNGISQWVQL MVLSRPTPQL RAEVFIKFIH VAQKLHQLQN FNTLMAVIGG 
LCHSSISRLK ETSSHVPHEI NKVLGEMTEL LSSCRNYDNY RRAYGECTHF KIPILGVHLK 
DLISLYEAMP DYLEDGKVNV QKLLALYNHI NELVQLQEMA PPLDANKDLV HLLTLSLDLY 
YTEDEIYELS YAREPRNHRA PPLTPSKPPV VVDWASGVSP KPDPKTISKH VQRMVDSVFK 
NYDLDQDGYI SQEEFEKIAA SFPFSFCVMD KDREGLISRD EITAYFMRAS SIYSKLGLGF 
PHNFQETTYL KPTFCDNCAG FLWGVIKQGY RCKDCGMNCH KQCKDLVVFE CKKRIKSPAI 
STENISSVVP MSTLCPLGTK DLLHAPEEGS FIFQNGEIVD HSEESKDRTI MLLGVSSQKI 
SVRLKRTVAH KSTQTESFPW VGGETTPGHF VLSSPRKSAQ GALYVHSPAS PCPSPALVRK 
RAFVKWENKE SLIKPKPELH LRLRTYQELE QEINTLKADN DALKIQLKYA QKKIESLQLG 
KSNHVLAQMD HGDSA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rasgrp1

Associated with

Other Information

RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions. PubMed ID: 10087292

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulation of RasGRP via a phorbol ester-responsive C1 domain. PubMed ID: 9819387

RasGRP is essential for mouse thymocyte differentiation and TCR signaling. PubMed ID: 11017103

RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation. PubMed ID: 12433368

Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. PubMed ID: 12932358

PubMed ID: 22808526

RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes. PubMed ID: 14532295

Transgenic expression of RasGRP1 induces the maturation of double-negative thymocytes and enhances the production of CD8 single-positive thymocytes. PubMed ID: 12538669

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. PubMed ID: 12845332

RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis. PubMed ID: 14970203

RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. PubMed ID: 16301621

Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors. PubMed ID: 15829980

RasGRP1 transmits prodifferentiation TCR signaling that is crucial for CD4 T cell development. PubMed ID: 16849453

Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs. PubMed ID: 17523924

Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin. PubMed ID: 17210708

An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. PubMed ID: 17190838

Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion. PubMed ID: 17675473

Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane. PubMed ID: 17567957

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079