Details for: AHR

Gene ID: 196

Symbol: AHR

Ensembl ID: ENSG00000106546

Description: aryl hydrocarbon receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.77
    Marker Score: 797
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.15
    Marker Score: 18903
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.13
    Marker Score: 3141
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.01
    Marker Score: 10586
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.01
    Marker Score: 1740
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.87
    Marker Score: 2141
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.79
    Marker Score: 8770
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.64
    Marker Score: 2388
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.61
    Marker Score: 674
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.6
    Marker Score: 1930
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.5
    Marker Score: 29856
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.49
    Marker Score: 83379
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167371
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.45
    Marker Score: 1524
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.45
    Marker Score: 1005
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.44
    Marker Score: 48866
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.43
    Marker Score: 414
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.37
    Marker Score: 674
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.35
    Marker Score: 3507
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.35
    Marker Score: 752
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.33
    Marker Score: 1355
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.29
    Marker Score: 1503.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.28
    Marker Score: 2554
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.27
    Marker Score: 348
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.26
    Marker Score: 8232
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.25
    Marker Score: 596
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.23
    Marker Score: 7820
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.23
    Marker Score: 819
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.22
    Marker Score: 834
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.22
    Marker Score: 294
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.22
    Marker Score: 75158
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.22
    Marker Score: 2218
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.21
    Marker Score: 309
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.21
    Marker Score: 5035
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.2
    Marker Score: 30787
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2
    Marker Score: 19250
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.19
    Marker Score: 8871
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.16
    Marker Score: 3044
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.16
    Marker Score: 10887
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.15
    Marker Score: 990
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.13
    Marker Score: 894
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.13
    Marker Score: 10721
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.12
    Marker Score: 2174
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.11
    Marker Score: 16604
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.11
    Marker Score: 476
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.1
    Marker Score: 6654
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17076
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.09
    Marker Score: 220
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.09
    Marker Score: 981
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.06
    Marker Score: 552
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.03
    Marker Score: 1829
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.02
    Marker Score: 6528
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.01
    Marker Score: 908
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.01
    Marker Score: 694
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71664
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1
    Marker Score: 224
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47889
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.99
    Marker Score: 224
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30387
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.98
    Marker Score: 33915.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.98
    Marker Score: 2481
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.97
    Marker Score: 1567
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.97
    Marker Score: 437
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.96
    Marker Score: 1038
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.96
    Marker Score: 233
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.95
    Marker Score: 427
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.95
    Marker Score: 34924
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.95
    Marker Score: 345
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.94
    Marker Score: 1547
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.94
    Marker Score: 835
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2392
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.93
    Marker Score: 560
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.93
    Marker Score: 639
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.93
    Marker Score: 531.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.92
    Marker Score: 1020
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.92
    Marker Score: 356
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.91
    Marker Score: 384
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.91
    Marker Score: 9408
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.91
    Marker Score: 1094
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.9
    Marker Score: 376
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.9
    Marker Score: 192
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2690
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.89
    Marker Score: 3693.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.89
    Marker Score: 278
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.87
    Marker Score: 481
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.87
    Marker Score: 405
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.86
    Marker Score: 7432
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.84
    Marker Score: 286
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.84
    Marker Score: 1331
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 483
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.83
    Marker Score: 289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1347
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.83
    Marker Score: 286
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.82
    Marker Score: 4693
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.81
    Marker Score: 247
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 326

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - AHR is a protein of 140 amino acids. - It is expressed in high levels in the lungs, bladder, and endothelial cells. - AHR is a nuclear receptor that is activated by a variety of ligands, including benzo[a]pyrene, a polycyclic aromatic hydrocarbon. - AHR signaling is involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis. **Pathways and functions:** - AHR signaling is involved in the regulation of lipid metabolism. - It is a key regulator of the expression of genes involved in cholesterol synthesis, fatty acid metabolism, and inflammation. - AHR signaling is also involved in the regulation of cell growth and differentiation. - AHR signaling is involved in the regulation of inflammation. **Clinical significance:** - Mutations in the AHR gene have been linked to a number of human diseases, including lung cancer, breast cancer, and cardiovascular disease. - AHR inhibitors are being investigated as a treatment for these diseases.

Genular Protein ID: 2923824030

Symbol: AHR_HUMAN

Name: Class E basic helix-loop-helix protein 76

UniProtKB Accession Codes:

P35869 A4D130 Q13728 Q13803 Q13804

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 21 DrugCentral 1 ELM 1 EMBL 17 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 47 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8393992

Title: Human Ah receptor cDNA: analysis for highly conserved sequences.

PubMed ID: 8393992

DOI: 10.1093/nar/21.15.3578

PubMed ID: 8246913

Title: Cloning and expression of a human Ah receptor cDNA.

PubMed ID: 8246913

PubMed ID: 7883760

Title: Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21.

PubMed ID: 7883760

DOI: 10.1093/oxfordjournals.jbchem.a124605

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16696038

Title: Complete structural characterisation of the human aryl hydrocarbon receptor gene.

PubMed ID: 16696038

DOI: 10.1136/mp.49.1.m12

PubMed ID: 7515333

Title: Interindividual difference in expression of human Ah receptor and related P450 genes.

PubMed ID: 7515333

DOI: 10.1093/carcin/15.5.801

PubMed ID: 7961644

Title: Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors.

PubMed ID: 7961644

DOI: 10.1016/s0021-9258(18)46990-6

PubMed ID: 10395741

Title: Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex.

PubMed ID: 10395741

DOI: 10.1006/abbi.1999.1282

PubMed ID: 11259615

Title: Cell-specific regulation of human aryl hydrocarbon receptor expression by transforming growth factor-beta(1).

PubMed ID: 11259615

DOI: 10.1124/mol.59.4.716

PubMed ID: 12213388

Title: Role of the aryl hydrocarbon receptor in cell cycle regulation.

PubMed ID: 12213388

DOI: 10.1016/s0009-2797(02)00069-8

PubMed ID: 12215427

Title: Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor.

PubMed ID: 12215427

DOI: 10.1074/jbc.m202413200

PubMed ID: 16582008

Title: The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein.

PubMed ID: 16582008

DOI: 10.1124/mol.106.024380

PubMed ID: 12213390

Title: Polymorphisms in the human AH receptor.

PubMed ID: 12213390

DOI: 10.1016/s0009-2797(02)00071-6

PubMed ID: 18076143

Title: The search for endogenous activators of the aryl hydrocarbon receptor.

PubMed ID: 18076143

DOI: 10.1021/tx7001965

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23275542

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.

PubMed ID: 23275542

DOI: 10.1093/nar/gks1337

PubMed ID: 30373764

Title: Characterization of TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP/ARTD14) Catalytic Activity.

PubMed ID: 30373764

DOI: 10.1042/bcj20180347

PubMed ID: 29726989

Title: A splicing mutation in aryl hydrocarbon receptor associated with retinitis pigmentosa.

PubMed ID: 29726989

DOI: 10.1093/hmg/ddy165

PubMed ID: 32818467

Title: IL4I1 is a metabolic immune checkpoint that activates the AHR and promotes tumor progression.

PubMed ID: 32818467

DOI: 10.1016/j.cell.2020.07.038

PubMed ID: 32866000

Title: An endogenous indole pyruvate pathway for tryptophan metabolism mediated by IL4I1.

PubMed ID: 32866000

DOI: 10.1021/acs.jafc.0c03735

PubMed ID: 34521881

Title: The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor.

PubMed ID: 34521881

DOI: 10.1038/s41598-021-97507-w

PubMed ID: 28602820

Title: Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.

PubMed ID: 28602820

DOI: 10.1016/j.str.2017.05.008

PubMed ID: 7550366

Title: Polymorphisms of human Ah receptor gene are not involved in lung cancer.

PubMed ID: 7550366

DOI: 10.1097/00008571-199506000-00003

PubMed ID: 10739168

Title: Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms.

PubMed ID: 10739168

DOI: 10.1097/00008571-200002000-00003

PubMed ID: 11698344

Title: Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer.

PubMed ID: 11698344

DOI: 10.1093/carcin/22.11.1819

PubMed ID: 11689007

Title: Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction.

PubMed ID: 11689007

DOI: 10.1006/bbrc.2001.5861

Sequence Information:

  • Length: 848
  • Mass: 96147
  • Checksum: 1BFE022871B7B028
  • Sequence:
    • MNSSSANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL ASLLPFPQDV 
INKLDKLSVL RLSVSYLRAK SFFDVALKSS PTERNGGQDN CRAANFREGL NLQEGEFLLQ 
ALNGFVLVVT TDALVFYASS TIQDYLGFQQ SDVIHQSVYE LIHTEDRAEF QRQLHWALNP 
SQCTESGQGI EEATGLPQTV VCYNPDQIPP ENSPLMERCF ICRLRCLLDN SSGFLAMNFQ 
GKLKYLHGQK KKGKDGSILP PQLALFAIAT PLQPPSILEI RTKNFIFRTK HKLDFTPIGC 
DAKGRIVLGY TEAELCTRGS GYQFIHAADM LYCAESHIRM IKTGESGMIV FRLLTKNNRW 
TWVQSNARLL YKNGRPDYII VTQRPLTDEE GTEHLRKRNT KLPFMFTTGE AVLYEATNPF 
PAIMDPLPLR TKNGTSGKDS ATTSTLSKDS LNPSSLLAAM MQQDESIYLY PASSTSSTAP 
FENNFFNESM NECRNWQDNT APMGNDTILK HEQIDQPQDV NSFAGGHPGL FQDSKNSDLY 
SIMKNLGIDF EDIRHMQNEK FFRNDFSGEV DFRDIDLTDE ILTYVQDSLS KSPFIPSDYQ 
QQQSLALNSS CMVQEHLHLE QQQQHHQKQV VVEPQQQLCQ KMKHMQVNGM FENWNSNQFV 
PFNCPQQDPQ QYNVFTDLHG ISQEFPYKSE MDSMPYTQNF ISCNQPVLPQ HSKCTELDYP 
MGSFEPSPYP TTSSLEDFVT CLQLPENQKH GLNPQSAIIT PQTCYAGAVS MYQCQPEPQH 
THVGQMQYNP VLPGQQAFLN KFQNGVLNET YPAELNNINN TQTTTHLQPL HHPSEARPFP 
DLTSSGFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.