Details for: AHR

Gene ID: 196

Symbol: AHR

Ensembl ID: ENSG00000106546

Description: aryl hydrocarbon receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 201.6777
    Cell Significance Index: -31.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 120.2081
    Cell Significance Index: -30.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.4388
    Cell Significance Index: -28.2100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 68.4991
    Cell Significance Index: -32.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.8603
    Cell Significance Index: -31.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.9243
    Cell Significance Index: -28.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.5565
    Cell Significance Index: -31.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3257
    Cell Significance Index: -30.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.4673
    Cell Significance Index: -20.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.0609
    Cell Significance Index: -27.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9928
    Cell Significance Index: -31.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.0546
    Cell Significance Index: 159.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.7243
    Cell Significance Index: 141.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.6638
    Cell Significance Index: 327.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2973
    Cell Significance Index: 21.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2289
    Cell Significance Index: 401.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.2040
    Cell Significance Index: 50.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.0742
    Cell Significance Index: 28.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2241
    Cell Significance Index: 35.0900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.2003
    Cell Significance Index: 19.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1955
    Cell Significance Index: 32.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0974
    Cell Significance Index: 108.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.0794
    Cell Significance Index: 19.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9898
    Cell Significance Index: 70.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9674
    Cell Significance Index: 10.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9347
    Cell Significance Index: 268.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8453
    Cell Significance Index: 39.7300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.7991
    Cell Significance Index: 4.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7131
    Cell Significance Index: 141.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6804
    Cell Significance Index: 136.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6495
    Cell Significance Index: 70.6500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6071
    Cell Significance Index: 6.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5820
    Cell Significance Index: 317.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5755
    Cell Significance Index: 93.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5737
    Cell Significance Index: 253.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5174
    Cell Significance Index: 11.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3636
    Cell Significance Index: 6.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3630
    Cell Significance Index: 18.3400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3509
    Cell Significance Index: 5.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2954
    Cell Significance Index: 11.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2817
    Cell Significance Index: 12.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2680
    Cell Significance Index: 51.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2439
    Cell Significance Index: 15.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2352
    Cell Significance Index: 5.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1993
    Cell Significance Index: 5.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1879
    Cell Significance Index: 67.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1847
    Cell Significance Index: 14.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1646
    Cell Significance Index: 19.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1441
    Cell Significance Index: 16.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0826
    Cell Significance Index: 2.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0616
    Cell Significance Index: 4.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0439
    Cell Significance Index: 5.0300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0366
    Cell Significance Index: 0.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0280
    Cell Significance Index: 25.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0215
    Cell Significance Index: 0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0198
    Cell Significance Index: 0.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0167
    Cell Significance Index: 2.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0153
    Cell Significance Index: 1.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0124
    Cell Significance Index: 9.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0050
    Cell Significance Index: -0.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0081
    Cell Significance Index: -14.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0110
    Cell Significance Index: -16.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0122
    Cell Significance Index: -23.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0140
    Cell Significance Index: -19.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0195
    Cell Significance Index: -12.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0216
    Cell Significance Index: -16.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0255
    Cell Significance Index: -2.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0313
    Cell Significance Index: -17.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0386
    Cell Significance Index: -28.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0400
    Cell Significance Index: -2.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0407
    Cell Significance Index: -1.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0439
    Cell Significance Index: -27.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0521
    Cell Significance Index: -1.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0611
    Cell Significance Index: -27.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0651
    Cell Significance Index: -8.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0759
    Cell Significance Index: -5.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0940
    Cell Significance Index: -19.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0992
    Cell Significance Index: -11.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1127
    Cell Significance Index: -6.9300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1243
    Cell Significance Index: -1.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1752
    Cell Significance Index: -25.4700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1977
    Cell Significance Index: -1.4200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2068
    Cell Significance Index: -0.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2089
    Cell Significance Index: -4.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2153
    Cell Significance Index: -10.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2389
    Cell Significance Index: -6.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3023
    Cell Significance Index: -31.4800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3083
    Cell Significance Index: -4.7700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3526
    Cell Significance Index: -4.4500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.3627
    Cell Significance Index: -3.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3781
    Cell Significance Index: -23.8300
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: -0.3819
    Cell Significance Index: -2.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3826
    Cell Significance Index: -30.3000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4001
    Cell Significance Index: -6.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4071
    Cell Significance Index: -24.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4411
    Cell Significance Index: -6.5100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4607
    Cell Significance Index: -2.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4923
    Cell Significance Index: -13.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5232
    Cell Significance Index: -29.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5274
    Cell Significance Index: -15.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ligand-activated transcription factor**: AHR is activated by planar aromatic hydrocarbons, such as TCDD, which bind to the ligand-binding domain of the receptor. 2. **DNA-binding transcription factor**: AHR binds to specific DNA sequences, known as Ah-receptor response elements (AREs), which are located upstream of target gene promoters. 3. **Nuclear receptor**: AHR is a nuclear receptor, meaning it resides in the nucleus and regulates gene expression by binding to specific DNA sequences. 4. **Basic helix-loop-helix (bHLH) protein**: AHR belongs to the bHLH protein family, which is characterized by a basic helix-loop-helix structure. 5. **Highly expressed in immune cells**: AHR is highly expressed in immune cells, such as macrophages and T cells, where it plays a crucial role in regulating immune responses. **Pathways and Functions** 1. **Immune response**: AHR regulates the expression of genes involved in immune response, including cytokines, chemokines, and adhesion molecules. 2. **Inflammation**: AHR modulates the expression of genes involved in inflammation, including prostaglandin synthase and cytokines. 3. **Cell cycle**: AHR regulates the expression of genes involved in cell growth and proliferation, including cyclin-dependent kinases and histone acetyltransferases. 4. **Metabolism**: AHR regulates the expression of genes involved in lipid metabolism, including peroxisome proliferator-activated receptor alpha (PPARα) and cytochrome P450 enzymes. 5. **Xenobiotic metabolism**: AHR is involved in the metabolism of xenobiotics, including TCDD and other planar aromatic hydrocarbons. **Clinical Significance** 1. **Cancer**: AHR has been implicated in the development and progression of various cancers, including lung, bladder, and breast cancer. 2. **Immunological disorders**: AHR has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and lupus. 3. **Environmental toxicology**: AHR is involved in the metabolism of TCDD and other planar aromatic hydrocarbons, which are environmental toxins. 4. **Xenobiotic metabolism**: AHR plays a crucial role in the metabolism of xenobiotics, which are substances that are not naturally produced by the body. 5. **Pharmacological applications**: AHR has been used as a model system to study the mechanism of action of various pharmaceuticals, including immunosuppressants and anti-inflammatory agents. In conclusion, the Aryl Hydrocarbon Receptor is a critical regulator of various cellular processes, including immune response, cell cycle, and metabolism. Its dysregulation has been implicated in various diseases, including cancer and immunological disorders. Further research is needed to fully understand the mechanisms of AHR and its clinical significance.

Genular Protein ID: 2923824030

Symbol: AHR_HUMAN

Name: Class E basic helix-loop-helix protein 76

UniProtKB Accession Codes:

P35869 A4D130 Q13728 Q13803 Q13804

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 21 DrugCentral 1 ELM 1 EMBL 17 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 46 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8393992

Title: Human Ah receptor cDNA: analysis for highly conserved sequences.

PubMed ID: 8393992

DOI: 10.1093/nar/21.15.3578

PubMed ID: 8246913

Title: Cloning and expression of a human Ah receptor cDNA.

PubMed ID: 8246913

PubMed ID: 7883760

Title: Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21.

PubMed ID: 7883760

DOI: 10.1093/oxfordjournals.jbchem.a124605

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16696038

Title: Complete structural characterisation of the human aryl hydrocarbon receptor gene.

PubMed ID: 16696038

DOI: 10.1136/mp.49.1.m12

PubMed ID: 7515333

Title: Interindividual difference in expression of human Ah receptor and related P450 genes.

PubMed ID: 7515333

DOI: 10.1093/carcin/15.5.801

PubMed ID: 7961644

Title: Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors.

PubMed ID: 7961644

DOI: 10.1016/s0021-9258(18)46990-6

PubMed ID: 10395741

Title: Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex.

PubMed ID: 10395741

DOI: 10.1006/abbi.1999.1282

PubMed ID: 11259615

Title: Cell-specific regulation of human aryl hydrocarbon receptor expression by transforming growth factor-beta(1).

PubMed ID: 11259615

DOI: 10.1124/mol.59.4.716

PubMed ID: 12213388

Title: Role of the aryl hydrocarbon receptor in cell cycle regulation.

PubMed ID: 12213388

DOI: 10.1016/s0009-2797(02)00069-8

PubMed ID: 12215427

Title: Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor.

PubMed ID: 12215427

DOI: 10.1074/jbc.m202413200

PubMed ID: 16582008

Title: The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein.

PubMed ID: 16582008

DOI: 10.1124/mol.106.024380

PubMed ID: 12213390

Title: Polymorphisms in the human AH receptor.

PubMed ID: 12213390

DOI: 10.1016/s0009-2797(02)00071-6

PubMed ID: 18076143

Title: The search for endogenous activators of the aryl hydrocarbon receptor.

PubMed ID: 18076143

DOI: 10.1021/tx7001965

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23275542

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.

PubMed ID: 23275542

DOI: 10.1093/nar/gks1337

PubMed ID: 30373764

Title: Characterization of TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP/ARTD14) Catalytic Activity.

PubMed ID: 30373764

DOI: 10.1042/bcj20180347

PubMed ID: 29726989

Title: A splicing mutation in aryl hydrocarbon receptor associated with retinitis pigmentosa.

PubMed ID: 29726989

DOI: 10.1093/hmg/ddy165

PubMed ID: 32818467

Title: IL4I1 is a metabolic immune checkpoint that activates the AHR and promotes tumor progression.

PubMed ID: 32818467

DOI: 10.1016/j.cell.2020.07.038

PubMed ID: 32866000

Title: An endogenous indole pyruvate pathway for tryptophan metabolism mediated by IL4I1.

PubMed ID: 32866000

DOI: 10.1021/acs.jafc.0c03735

PubMed ID: 34521881

Title: The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor.

PubMed ID: 34521881

DOI: 10.1038/s41598-021-97507-w

PubMed ID: 28602820

Title: Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.

PubMed ID: 28602820

DOI: 10.1016/j.str.2017.05.008

PubMed ID: 7550366

Title: Polymorphisms of human Ah receptor gene are not involved in lung cancer.

PubMed ID: 7550366

DOI: 10.1097/00008571-199506000-00003

PubMed ID: 10739168

Title: Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms.

PubMed ID: 10739168

DOI: 10.1097/00008571-200002000-00003

PubMed ID: 11698344

Title: Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer.

PubMed ID: 11698344

DOI: 10.1093/carcin/22.11.1819

PubMed ID: 11689007

Title: Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction.

PubMed ID: 11689007

DOI: 10.1006/bbrc.2001.5861

Sequence Information:

  • Length: 848
  • Mass: 96147
  • Checksum: 1BFE022871B7B028
  • Sequence:
    • MNSSSANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL ASLLPFPQDV 
INKLDKLSVL RLSVSYLRAK SFFDVALKSS PTERNGGQDN CRAANFREGL NLQEGEFLLQ 
ALNGFVLVVT TDALVFYASS TIQDYLGFQQ SDVIHQSVYE LIHTEDRAEF QRQLHWALNP 
SQCTESGQGI EEATGLPQTV VCYNPDQIPP ENSPLMERCF ICRLRCLLDN SSGFLAMNFQ 
GKLKYLHGQK KKGKDGSILP PQLALFAIAT PLQPPSILEI RTKNFIFRTK HKLDFTPIGC 
DAKGRIVLGY TEAELCTRGS GYQFIHAADM LYCAESHIRM IKTGESGMIV FRLLTKNNRW 
TWVQSNARLL YKNGRPDYII VTQRPLTDEE GTEHLRKRNT KLPFMFTTGE AVLYEATNPF 
PAIMDPLPLR TKNGTSGKDS ATTSTLSKDS LNPSSLLAAM MQQDESIYLY PASSTSSTAP 
FENNFFNESM NECRNWQDNT APMGNDTILK HEQIDQPQDV NSFAGGHPGL FQDSKNSDLY 
SIMKNLGIDF EDIRHMQNEK FFRNDFSGEV DFRDIDLTDE ILTYVQDSLS KSPFIPSDYQ 
QQQSLALNSS CMVQEHLHLE QQQQHHQKQV VVEPQQQLCQ KMKHMQVNGM FENWNSNQFV 
PFNCPQQDPQ QYNVFTDLHG ISQEFPYKSE MDSMPYTQNF ISCNQPVLPQ HSKCTELDYP 
MGSFEPSPYP TTSSLEDFVT CLQLPENQKH GLNPQSAIIT PQTCYAGAVS MYQCQPEPQH 
THVGQMQYNP VLPGQQAFLN KFQNGVLNET YPAELNNINN TQTTTHLQPL HHPSEARPFP 
DLTSSGFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.