AHR | ENSG00000106546 | NCBI 196

Details for: AHR

Gene ID: 196

Symbol: AHR

Ensembl ID: ENSG00000106546

Description: aryl hydrocarbon receptor

Associated with

Aryl hydrocarbon receptor signalling
(R-HSA-8937144)
Biological oxidations
(R-HSA-211859)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Endogenous sterols
(R-HSA-211976)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phase i - functionalization of compounds
(R-HSA-211945)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Xenobiotics
(R-HSA-211981)
Apoptotic process
(GO:0006915)
Aryl hydrocarbon receptor complex
(GO:0034751)
Blood vessel development
(GO:0001568)
Camp-mediated signaling
(GO:0019933)
Cell cycle
(GO:0007049)
Cellular response to 2,3,7,8-tetrachlorodibenzodioxine
(GO:1904613)
Cellular response to camp
(GO:0071320)
Cellular response to forskolin
(GO:1904322)
Cellular response to molecule of bacterial origin
(GO:0071219)
Chromatin
(GO:0000785)
Circadian regulation of gene expression
(GO:0032922)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Cytosolic aryl hydrocarbon receptor complex
(GO:0034752)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
E-box binding
(GO:0070888)
Hsp90 protein binding
(GO:0051879)
Intracellular receptor signaling pathway
(GO:0030522)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of t cell mediated immune response to tumor cell
(GO:0002841)
Nuclear aryl hydrocarbon receptor complex
(GO:0034753)
Nuclear receptor activity
(GO:0004879)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of adaptive immune response
(GO:0002819)
Regulation of b cell proliferation
(GO:0030888)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to toxic substance
(GO:0009636)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Sequence-specific double-stranded dna binding
(GO:1990837)
Tbp-class protein binding
(GO:0017025)
Tfiid-class transcription factor complex binding
(GO:0001094)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transcription regulator complex
(GO:0005667)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Class E basic helix-loop-helix protein 76

Genular Protein ID: 2923824030

Symbol: AHR_HUMAN

Name: Class E basic helix-loop-helix protein 76

UniProtKB Accession Codes:

P35869 A4D130 Q13728 Q13803 Q13804

Database IDs:

Citations:

PubMed ID: 8393992

Title: Human Ah receptor cDNA: analysis for highly conserved sequences.

PubMed ID: 8393992

DOI: 10.1093/nar/21.15.3578

PubMed ID: 8246913

Title: Cloning and expression of a human Ah receptor cDNA.

PubMed ID: 8246913

PubMed ID: 7883760

Title: Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21.

PubMed ID: 7883760

DOI: 10.1093/oxfordjournals.jbchem.a124605

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16696038

Title: Complete structural characterisation of the human aryl hydrocarbon receptor gene.

PubMed ID: 16696038

DOI: 10.1136/mp.49.1.m12

PubMed ID: 7515333

Title: Interindividual difference in expression of human Ah receptor and related P450 genes.

PubMed ID: 7515333

DOI: 10.1093/carcin/15.5.801

PubMed ID: 7961644

Title: Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors.

PubMed ID: 7961644

DOI: 10.1016/s0021-9258(18)46990-6

PubMed ID: 10395741

Title: Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex.

PubMed ID: 10395741

DOI: 10.1006/abbi.1999.1282

PubMed ID: 11259615

Title: Cell-specific regulation of human aryl hydrocarbon receptor expression by transforming growth factor-beta(1).

PubMed ID: 11259615

DOI: 10.1124/mol.59.4.716

PubMed ID: 12213388

Title: Role of the aryl hydrocarbon receptor in cell cycle regulation.

PubMed ID: 12213388

DOI: 10.1016/s0009-2797(02)00069-8

PubMed ID: 12215427

Title: Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor.

PubMed ID: 12215427

DOI: 10.1074/jbc.m202413200

PubMed ID: 16582008

Title: The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein.

PubMed ID: 16582008

DOI: 10.1124/mol.106.024380

PubMed ID: 12213390

Title: Polymorphisms in the human AH receptor.

PubMed ID: 12213390

DOI: 10.1016/s0009-2797(02)00071-6

PubMed ID: 18076143

Title: The search for endogenous activators of the aryl hydrocarbon receptor.

PubMed ID: 18076143

DOI: 10.1021/tx7001965

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23275542

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.

PubMed ID: 23275542

DOI: 10.1093/nar/gks1337

PubMed ID: 30373764

Title: Characterization of TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP/ARTD14) Catalytic Activity.

PubMed ID: 30373764

DOI: 10.1042/bcj20180347

PubMed ID: 29726989

Title: A splicing mutation in aryl hydrocarbon receptor associated with retinitis pigmentosa.

PubMed ID: 29726989

DOI: 10.1093/hmg/ddy165

PubMed ID: 32818467

Title: IL4I1 is a metabolic immune checkpoint that activates the AHR and promotes tumor progression.

PubMed ID: 32818467

DOI: 10.1016/j.cell.2020.07.038

PubMed ID: 32866000

Title: An endogenous indole pyruvate pathway for tryptophan metabolism mediated by IL4I1.

PubMed ID: 32866000

DOI: 10.1021/acs.jafc.0c03735

PubMed ID: 34521881

Title: The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor.

PubMed ID: 34521881

DOI: 10.1038/s41598-021-97507-w

PubMed ID: 28602820

Title: Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.

PubMed ID: 28602820

DOI: 10.1016/j.str.2017.05.008

PubMed ID: 7550366

Title: Polymorphisms of human Ah receptor gene are not involved in lung cancer.

PubMed ID: 7550366

DOI: 10.1097/00008571-199506000-00003

PubMed ID: 10739168

Title: Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms.

PubMed ID: 10739168

DOI: 10.1097/00008571-200002000-00003

PubMed ID: 11698344

Title: Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer.

PubMed ID: 11698344

DOI: 10.1093/carcin/22.11.1819

PubMed ID: 11689007

Title: Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction.

PubMed ID: 11689007

DOI: 10.1006/bbrc.2001.5861

Sequence Information:

Length: 848
Mass: 96147
Checksum: 1BFE022871B7B028
Sequence:

MNSSSANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL ASLLPFPQDV 
INKLDKLSVL RLSVSYLRAK SFFDVALKSS PTERNGGQDN CRAANFREGL NLQEGEFLLQ 
ALNGFVLVVT TDALVFYASS TIQDYLGFQQ SDVIHQSVYE LIHTEDRAEF QRQLHWALNP 
SQCTESGQGI EEATGLPQTV VCYNPDQIPP ENSPLMERCF ICRLRCLLDN SSGFLAMNFQ 
GKLKYLHGQK KKGKDGSILP PQLALFAIAT PLQPPSILEI RTKNFIFRTK HKLDFTPIGC 
DAKGRIVLGY TEAELCTRGS GYQFIHAADM LYCAESHIRM IKTGESGMIV FRLLTKNNRW 
TWVQSNARLL YKNGRPDYII VTQRPLTDEE GTEHLRKRNT KLPFMFTTGE AVLYEATNPF 
PAIMDPLPLR TKNGTSGKDS ATTSTLSKDS LNPSSLLAAM MQQDESIYLY PASSTSSTAP 
FENNFFNESM NECRNWQDNT APMGNDTILK HEQIDQPQDV NSFAGGHPGL FQDSKNSDLY 
SIMKNLGIDF EDIRHMQNEK FFRNDFSGEV DFRDIDLTDE ILTYVQDSLS KSPFIPSDYQ 
QQQSLALNSS CMVQEHLHLE QQQQHHQKQV VVEPQQQLCQ KMKHMQVNGM FENWNSNQFV 
PFNCPQQDPQ QYNVFTDLHG ISQEFPYKSE MDSMPYTQNF ISCNQPVLPQ HSKCTELDYP 
MGSFEPSPYP TTSSLEDFVT CLQLPENQKH GLNPQSAIIT PQTCYAGAVS MYQCQPEPQH 
THVGQMQYNP VLPGQQAFLN KFQNGVLNET YPAELNNINN TQTTTHLQPL HHPSEARPFP 
DLTSSGFL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AHR

Associated with

Other Information

Human Ah receptor cDNA: analysis for highly conserved sequences. PubMed ID: 8393992

Cloning and expression of a human Ah receptor cDNA. PubMed ID: 8246913

Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21. PubMed ID: 7883760

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete structural characterisation of the human aryl hydrocarbon receptor gene. PubMed ID: 16696038

Interindividual difference in expression of human Ah receptor and related P450 genes. PubMed ID: 7515333

Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. PubMed ID: 7961644

Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. PubMed ID: 10395741

Cell-specific regulation of human aryl hydrocarbon receptor expression by transforming growth factor-beta(1). PubMed ID: 11259615

Role of the aryl hydrocarbon receptor in cell cycle regulation. PubMed ID: 12213388

Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor. PubMed ID: 12215427

The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein. PubMed ID: 16582008

Polymorphisms in the human AH receptor. PubMed ID: 12213390

The search for endogenous activators of the aryl hydrocarbon receptor. PubMed ID: 18076143

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. PubMed ID: 23275542

Characterization of TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP/ARTD14) Catalytic Activity. PubMed ID: 30373764

A splicing mutation in aryl hydrocarbon receptor associated with retinitis pigmentosa. PubMed ID: 29726989

IL4I1 is a metabolic immune checkpoint that activates the AHR and promotes tumor progression. PubMed ID: 32818467

An endogenous indole pyruvate pathway for tryptophan metabolism mediated by IL4I1. PubMed ID: 32866000

The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor. PubMed ID: 34521881

Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation. PubMed ID: 28602820

Polymorphisms of human Ah receptor gene are not involved in lung cancer. PubMed ID: 7550366

Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. PubMed ID: 10739168

Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. PubMed ID: 11698344

Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction. PubMed ID: 11689007