Genular: Defining Cellular Identity and Function

Details for: Rb1

Gene ID: 19645

Symbol: Rb1

Ensembl ID: ENSMUSG00000022105

Description: RB transcriptional corepressor 1

Associated with

Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-MMU-174178)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Condensation of prophase chromosomes
(R-MMU-2299718)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin d associated events in g1
(R-MMU-69231)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Dna damage/telomere stress induced senescence
(R-MMU-2559586)
E2f mediated regulation of dna replication
(R-MMU-113510)
Formation of senescence-associated heterochromatin foci (sahf)
(R-MMU-2559584)
G1 phase
(R-MMU-69236)
G1/s transition
(R-MMU-69206)
Inhibition of replication initiation of damaged dna by rb1/e2f1
(R-MMU-113501)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic prophase
(R-MMU-68875)
M phase
(R-MMU-68886)
Phosphorylation of proteins involved in g1/s transition by active cyclin e:cdk2 complexes
(R-MMU-69200)
S phase
(R-MMU-69242)
Aortic valve morphogenesis
(GO:0003180)
Apoptotic process
(GO:0006915)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Cell division
(GO:0051301)
Cell morphogenesis involved in neuron differentiation
(GO:0048667)
Cell population proliferation
(GO:0008283)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to xenobiotic stimulus
(GO:0071466)
Chondrocyte differentiation
(GO:0002062)
Chromatin organization
(GO:0006325)
Chromosome organization
(GO:0051276)
Digestive tract development
(GO:0048565)
Disordered domain specific binding
(GO:0097718)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Enucleate erythrocyte differentiation
(GO:0043353)
Enzyme binding
(GO:0019899)
Epithelial cell proliferation
(GO:0050673)
G1/s transition of mitotic cell cycle
(GO:0000082)
Glial cell apoptotic process
(GO:0034349)
Glial cell proliferation
(GO:0014009)
Heterochromatin formation
(GO:0031507)
Identical protein binding
(GO:0042802)
Importin-alpha family protein binding
(GO:0061676)
Kinase binding
(GO:0019900)
Maintenance of mitotic sister chromatid cohesion
(GO:0034088)
Molecular adaptor activity
(GO:0060090)
Myoblast differentiation
(GO:0045445)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of glial cell proliferation
(GO:0060253)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of mitotic cell cycle
(GO:0045930)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron apoptotic process
(GO:0051402)
Neuron differentiation
(GO:0030182)
Neuron maturation
(GO:0042551)
Neuron projection development
(GO:0031175)
Phosphoprotein binding
(GO:0051219)
Positive regulation of macrophage differentiation
(GO:0045651)
Positive regulation of mitotic metaphase/anaphase transition
(GO:0045842)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein localization to chromosome, centromeric region
(GO:0071459)
Regulation of cell cycle
(GO:0051726)
Regulation of cell growth
(GO:0001558)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of lipid kinase activity
(GO:0043550)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sister chromatid biorientation
(GO:0031134)
Skeletal muscle cell differentiation
(GO:0035914)
Smoothened signaling pathway
(GO:0007224)
Striated muscle cell differentiation
(GO:0051146)
Tissue homeostasis
(GO:0001894)
Transcription by rna polymerase ii
(GO:0006366)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Retinoblastoma-associated protein

Genular Protein ID: 3703893277

Symbol: RB_MOUSE

Name: Retinoblastoma-associated protein

UniProtKB Accession Codes:

P13405 Q4VA62

Database IDs:

Citations:

PubMed ID: 2671991

Title: Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.

PubMed ID: 2671991

DOI: 10.1073/pnas.86.17.6474

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8336704

Title: A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity.

PubMed ID: 8336704

DOI: 10.1128/mcb.13.8.4588-4599.1993

PubMed ID: 10888886

Title: DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.

PubMed ID: 10888886

DOI: 10.1038/77124

PubMed ID: 10869426

Title: pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.

PubMed ID: 10869426

DOI: 10.1073/pnas.130198397

PubMed ID: 11571651

Title: Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130.

PubMed ID: 11571651

DOI: 10.1038/sj.onc.1204823

PubMed ID: 12095676

Title: Isolation, characterization and mapping of the mouse and human RB1CC1 genes.

PubMed ID: 12095676

DOI: 10.1016/s0378-1119(02)00585-1

PubMed ID: 15750587

Title: Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin.

PubMed ID: 15750587

DOI: 10.1038/ncb1235

PubMed ID: 15983387

Title: Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis.

PubMed ID: 15983387

DOI: 10.1073/pnas.0504222102

PubMed ID: 16616919

Title: The arginine methyltransferase PRMT2 binds RB and regulates E2F function.

PubMed ID: 16616919

DOI: 10.1016/j.yexcr.2006.03.001

PubMed ID: 16612004

Title: The retinoblastoma protein regulates pericentric heterochromatin.

PubMed ID: 16612004

DOI: 10.1128/mcb.26.9.3659-3671.2006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20940255

Title: Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation.

PubMed ID: 20940255

DOI: 10.1242/jcs.068924

PubMed ID: 20668449

Title: NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.

PubMed ID: 20668449

DOI: 10.1038/nature09343

Sequence Information:

Length: 921
Mass: 105367
Checksum: AE81D35A07ADB493
Sequence:

MPPKAPRRAA AAEPPPPPPP PPREDDPAQD SGPEELPLAR LEFEEIEEPE FIALCQKLKV 
PDHVRERAWL TWEKVSSVDG ILEGYIQKKK ELWGICIFIA AVDLDEMPFT FTELQKSIET 
SVYKFFDLLK EIDTSTKVDN AMSRLLKKYN VLCALYSKLE RTCELIYLTQ PSSALSTEIN 
SMLVLKISWI TFLLAKGEVL QMEDDLVISF QLMLCVVDYF IKFSPPALLR EPYKTAAIPI 
NGSPRTPRRG QNRSARIAKQ LENDTRIIEV LCKEHECNID EVKNVYFKNF IPFINSLGIV 
SSNGLPEVES LSKRYEEVYL KNKDLDARLF LDHDKTLQTD PIDSFETERT PRKNNPDEEA 
NVVTPHTPVR TVMNTIQQLM VILNSASDQP SENLISYFNN CTVNPKENIL KRVKDVGHIF 
KEKFANAVGQ GCVDIGVQRY KLGVRLYYRV MESMLKSEEE RLSIQNFSKL LNDNIFHMSL 
LACALEVVMA TYSRSTLQHL DSGTDLSFPW ILNVLNLKAF DFYKVIESFI KVEANLTREM 
IKHLERCEHR IMESLAWLSD SPLFDLIKQS KDGEGPDNLE PACPLSLPLQ GNHTAADMYL 
SPLRSPKKRT STTRVNSAAN TETQAASAFH TQKPLKSTSL ALFYKKVYRL AYLRLNTLCA 
RLLSDHPELE HIIWTLFQHT LQNEYELMRD RHLDQIMMCS MYGICKVKNI DLKFKIIVTA 
YKDLPHAAQE TFKRVLIREE EFDSIIVFYN SVFMQRLKTN ILQYASTRPP TLSPIPHIPR 
SPYKFSSSPL RIPGGNIYIS PLKSPYKISE GLPTPTKMTP RSRILVSIGE SFGTSEKFQK 
INQMVCNSDR VLKRSAEGGN PPKPLKKLRF DIEGADEADG SKHLPAESKF QQKLAEMTST 
RTRMQKQRMN ESKDVSNKEE K

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rb1

Associated with

Other Information

Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein. PubMed ID: 2671991

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity. PubMed ID: 8336704

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. PubMed ID: 10888886

pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. PubMed ID: 10869426

Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130. PubMed ID: 11571651

Isolation, characterization and mapping of the mouse and human RB1CC1 genes. PubMed ID: 12095676

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. PubMed ID: 15750587

Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. PubMed ID: 15983387

The arginine methyltransferase PRMT2 binds RB and regulates E2F function. PubMed ID: 16616919

The retinoblastoma protein regulates pericentric heterochromatin. PubMed ID: 16612004

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. PubMed ID: 20940255

NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. PubMed ID: 20668449