Genular: Defining Cellular Identity and Function

Details for: Reg3g

Gene ID: 19695

Symbol: Reg3g

Ensembl ID: ENSMUSG00000030017

Description: regenerating islet-derived 3 gamma

Associated with

Antimicrobial peptides
(R-MMU-6803157)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Acute-phase response
(GO:0006953)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Carbohydrate binding
(GO:0030246)
Collagen-containing extracellular matrix
(GO:0062023)
Cytoplasm
(GO:0005737)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to gram-positive bacterium
(GO:0050830)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hormone activity
(GO:0005179)
Inflammatory response
(GO:0006954)
Metal ion binding
(GO:0046872)
Myd88-dependent toll-like receptor signaling pathway
(GO:0002755)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of inflammatory response to wounding
(GO:0106015)
Negative regulation of keratinocyte differentiation
(GO:0045617)
Oligosaccharide binding
(GO:0070492)
Peptidoglycan binding
(GO:0042834)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of detection of glucose
(GO:2000972)
Positive regulation of keratinocyte proliferation
(GO:0010838)
Positive regulation of wound healing
(GO:0090303)
Response to bacterium
(GO:0009617)
Response to peptide hormone
(GO:0043434)
Response to symbiotic bacterium
(GO:0009609)
Secretory granule
(GO:0030141)
Signaling receptor activity
(GO:0038023)

Other Information

Proteins

Pancreatitis-associated protein 3

Genular Protein ID: 614332783

Symbol: REG3G_MOUSE

Name: Pancreatitis-associated protein 3

UniProtKB Accession Codes:

O09049

Database IDs:

Citations:

PubMed ID: 9055810

Title: Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma.

PubMed ID: 9055810

DOI: 10.1016/s0378-1119(96)00589-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19095652

Title: Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment.

PubMed ID: 19095652

DOI: 10.1074/jbc.m808077200

PubMed ID: 16504538

Title: Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coli.

PubMed ID: 16504538

DOI: 10.1016/j.pep.2006.01.014

PubMed ID: 16931762

Title: Symbiotic bacteria direct expression of an intestinal bactericidal lectin.

PubMed ID: 16931762

DOI: 10.1126/science.1127119

PubMed ID: 17635956

Title: MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection.

PubMed ID: 17635956

DOI: 10.1084/jem.20070563

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21998396

Title: The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine.

PubMed ID: 21998396

DOI: 10.1126/science.1209791

PubMed ID: 22727489

Title: The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury.

PubMed ID: 22727489

DOI: 10.1016/j.immuni.2012.04.010

PubMed ID: 23401489

Title: Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia.

PubMed ID: 23401489

DOI: 10.1084/jem.20120260

PubMed ID: 27830702

Title: Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes.

PubMed ID: 27830702

DOI: 10.1038/ncomms13393

PubMed ID: 28811323

Title: IL-22 induces Reg3gamma and inhibits allergic inflammation in house dust mite-induced asthma models.

PubMed ID: 28811323

DOI: 10.1084/jem.20162108

PubMed ID: 36240758

Title: The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function.

PubMed ID: 36240758

DOI: 10.1016/j.cmet.2022.09.024

PubMed ID: 35263589

Title: Nociceptor-derived Reg3gamma prevents endotoxic death by targeting kynurenine pathway in microglia.

PubMed ID: 35263589

DOI: 10.1016/j.celrep.2022.110462

Sequence Information:

Length: 174
Mass: 19307
Checksum: 5575E9E56A4D8CEF
Sequence:

MLPRITITIM SWMLLSCLML LSQVQGEVAK KDAPSSRSSC PKGSRAYGSY CYALFSVSKN 
WYDADMACQK RPSGHLVSVL SGAEASFLSS MIKSSGNSGQ YVWIGLHDPT LGYEPNRGGW 
EWSNADVMNY INWETNPSSS SGNHCGTLSR ASGFLKWREN YCNLELPYVC KFKA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Reg3g

Associated with

Other Information

Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma. PubMed ID: 9055810

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment. PubMed ID: 19095652

Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coli. PubMed ID: 16504538

Symbiotic bacteria direct expression of an intestinal bactericidal lectin. PubMed ID: 16931762

MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. PubMed ID: 17635956

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. PubMed ID: 21998396

The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. PubMed ID: 22727489

Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia. PubMed ID: 23401489

Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes. PubMed ID: 27830702

IL-22 induces Reg3gamma and inhibits allergic inflammation in house dust mite-induced asthma models. PubMed ID: 28811323

The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function. PubMed ID: 36240758

Nociceptor-derived Reg3gamma prevents endotoxic death by targeting kynurenine pathway in microglia. PubMed ID: 35263589