Genular: Defining Cellular Identity and Function

Details for: Rela

Gene ID: 19697

Symbol: Rela

Ensembl ID: ENSMUSG00000024927

Description: v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Associated with

Activation of nf-kappab in b cells
(R-MMU-1169091)
Adaptive immune system
(R-MMU-1280218)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Cd209 (dc-sign) signaling
(R-MMU-5621575)
Chromatin modifying enzymes
(R-MMU-3247509)
Chromatin organization
(R-MMU-4839726)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cytokine signaling in immune system
(R-MMU-1280215)
Cytosolic sensors of pathogen-associated dna
(R-MMU-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-MMU-168928)
Death receptor signaling
(R-MMU-73887)
Dex/h-box helicases activate type i ifn and inflammatory cytokines production
(R-MMU-3134963)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Downstream tcr signaling
(R-MMU-202424)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 processing
(R-MMU-448706)
Interleukin-1 signaling
(R-MMU-9020702)
Metabolism of proteins
(R-MMU-392499)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Nf-kb is activated and signals survival
(R-MMU-209560)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
P75ntr signals via nf-kb
(R-MMU-193639)
Pkmts methylate histone lysines
(R-MMU-3214841)
Post-translational protein modification
(R-MMU-597592)
Regulated proteolysis of p75ntr
(R-MMU-193692)
Rip-mediated nfkb activation via zbp1
(R-MMU-1810476)
Signaling by interleukins
(R-MMU-449147)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of immune response proteins
(R-MMU-4755510)
Tak1-dependent ikk and nf-kappa-b activation
(R-MMU-445989)
Tcr signaling
(R-MMU-202403)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Traf6 mediated nf-kb activation
(R-MMU-933542)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Zbp1(dai) mediated induction of type i ifns
(R-MMU-1606322)
Actinin binding
(GO:0042805)
Ankyrin repeat binding
(GO:0071532)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Enzyme binding
(GO:0019899)
General transcription initiation factor binding
(GO:0140296)
Histone deacetylase binding
(GO:0042826)
Identical protein binding
(GO:0042802)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nf-kappab binding
(GO:0051059)
Peptide binding
(GO:0042277)
Phosphate ion binding
(GO:0042301)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transcription regulator activity
(GO:0140110)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Transcription factor p65

Genular Protein ID: 2415280775

Symbol: TF65_MOUSE

Name: Transcription factor p65

UniProtKB Accession Codes:

Q04207 Q62025

Database IDs:

Citations:

PubMed ID: 2001591

Title: DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide.

PubMed ID: 2001591

DOI: 10.1016/0092-8674(91)90320-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8918242

Title: Cloning of the murine relA (p65 NF-kappa B) gene and comparison to the human gene reveals a distinct first intron.

PubMed ID: 8918242

DOI: 10.1016/0378-1119(96)00231-4

PubMed ID: 8281153

Title: Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing.

PubMed ID: 8281153

DOI: 10.1093/hmg/2.11.1895

PubMed ID: 8816457

Title: Role of unphosphorylated, newly synthesized IkappaB beta in persistent activation of NF-kappaB.

PubMed ID: 8816457

DOI: 10.1128/mcb.16.10.5444

PubMed ID: 9990853

Title: Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP.

PubMed ID: 9990853

DOI: 10.1101/gad.13.3.284

PubMed ID: 11931770

Title: Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor.

PubMed ID: 11931770

DOI: 10.1016/s1097-2765(02)00469-0

PubMed ID: 12881425

Title: Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation.

PubMed ID: 12881425

DOI: 10.1093/emboj/cdg370

PubMed ID: 12874295

Title: Critical role of RelB serine 368 for dimerization and p100 stabilization.

PubMed ID: 12874295

DOI: 10.1074/jbc.m301521200

PubMed ID: 15051764

Title: A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells.

PubMed ID: 15051764

DOI: 10.1084/jem.20031272

PubMed ID: 15485901

Title: Tumor necrosis factor alpha induction of NF-kappaB requires the novel coactivator SIMPL.

PubMed ID: 15485901

DOI: 10.1128/mcb.24.21.9317-9326.2004

PubMed ID: 15616592

Title: Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression.

PubMed ID: 15616592

DOI: 10.1038/sj.emboj.7600500

PubMed ID: 18710934

Title: The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis.

PubMed ID: 18710934

DOI: 10.1128/mcb.00299-08

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21131967

Title: Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling.

PubMed ID: 21131967

DOI: 10.1038/ni.1968

PubMed ID: 22244329

Title: Hydrogen sulfide-linked sulfhydration of NF-kappaB mediates its antiapoptotic actions.

PubMed ID: 22244329

DOI: 10.1016/j.molcel.2011.10.021

PubMed ID: 22921934

Title: Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.

PubMed ID: 22921934

DOI: 10.1016/j.molcel.2012.07.020

PubMed ID: 22895791

Title: Core circadian protein CLOCK is a positive regulator of NF-kappaB-mediated transcription.

PubMed ID: 22895791

DOI: 10.1073/pnas.1206274109

PubMed ID: 23616576

Title: Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet.

PubMed ID: 23616576

DOI: 10.4049/jimmunol.1203403

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 25024434

Title: K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation.

PubMed ID: 25024434

DOI: 10.15252/embj.201487870

PubMed ID: 28600438

Title: Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration.

PubMed ID: 28600438

DOI: 10.1084/jem.20160724

PubMed ID: 28378844

Title: MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-kappaB and negatively regulates inflammatory responses.

PubMed ID: 28378844

DOI: 10.1038/srep46097

PubMed ID: 29813070

Title: Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors.

PubMed ID: 29813070

DOI: 10.1371/journal.pbio.2004526

PubMed ID: 9865694

Title: The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.

PubMed ID: 9865694

DOI: 10.1016/s0092-8674(00)81699-2

PubMed ID: 9437432

Title: A novel DNA recognition mode by the NF-kappa B p65 homodimer.

PubMed ID: 9437432

DOI: 10.1038/nsb0198-67

PubMed ID: 9450761

Title: Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA.

PubMed ID: 9450761

DOI: 10.1038/34956

Sequence Information:

Length: 549
Mass: 60212
Checksum: BDF1673D2FE398B9
Sequence:

MDDLFPLIFP SEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER STDTTKTHPT 
IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGYY EADLCPDRSI HSFQNLGIQC 
VKKRDLEQAI SQRIQTNNNP FHVPIEEQRG DYDLNAVRLC FQVTVRDPAG RPLLLTPVLS 
HPIFDNRAPN TAELKICRVN RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS 
QADVHRQVAI VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE 
KRKRTYETFK SIMKKSPFNG PTEPRPPTRR IAVPTRNSTS VPKPAPQPYT FPASLSTINF 
DEFSPMLLPS GQISNQALAL APSSAPVLAQ TMVPSSAMVP LAQPPAPAPV LTPGPPQSLS 
APVPKSTQAG EGTLSEALLH LQFDADEDLG ALLGNSTDPG VFTDLASVDN SEFQQLLNQG 
VSMSHSTAEP MLMEYPEAIT RLVTGSQRPP DPAPTPLGTS GLPNGLSGDE DFSSIADMDF 
SALLSQISS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rela

Associated with

Other Information

DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. PubMed ID: 2001591

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning of the murine relA (p65 NF-kappa B) gene and comparison to the human gene reveals a distinct first intron. PubMed ID: 8918242

Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing. PubMed ID: 8281153

Role of unphosphorylated, newly synthesized IkappaB beta in persistent activation of NF-kappaB. PubMed ID: 8816457

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. PubMed ID: 9990853

Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. PubMed ID: 11931770

Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. PubMed ID: 12881425

Critical role of RelB serine 368 for dimerization and p100 stabilization. PubMed ID: 12874295

A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells. PubMed ID: 15051764

Tumor necrosis factor alpha induction of NF-kappaB requires the novel coactivator SIMPL. PubMed ID: 15485901

Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. PubMed ID: 15616592

The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis. PubMed ID: 18710934

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling. PubMed ID: 21131967

Hydrogen sulfide-linked sulfhydration of NF-kappaB mediates its antiapoptotic actions. PubMed ID: 22244329

Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. PubMed ID: 22921934

Core circadian protein CLOCK is a positive regulator of NF-kappaB-mediated transcription. PubMed ID: 22895791

Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet. PubMed ID: 23616576

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation. PubMed ID: 25024434

Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. PubMed ID: 28600438

MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-kappaB and negatively regulates inflammatory responses. PubMed ID: 28378844

Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors. PubMed ID: 29813070

The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. PubMed ID: 9865694

A novel DNA recognition mode by the NF-kappa B p65 homodimer. PubMed ID: 9437432

Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. PubMed ID: 9450761