Genular: Defining Cellular Identity and Function

Details for: Relb

Gene ID: 19698

Symbol: Relb

Ensembl ID: ENSMUSG00000002983

Description: avian reticuloendotheliosis viral (v-rel) oncogene related B

Associated with

C-type lectin receptors (clrs)
(R-MMU-5621481)
Cd209 (dc-sign) signaling
(R-MMU-5621575)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cytokine signaling in immune system
(R-MMU-1280215)
Dectin-1 mediated noncanonical nf-kb signaling
(R-MMU-5607761)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Nik-->noncanonical nf-kb signaling
(R-MMU-5676590)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Antigen processing and presentation
(GO:0019882)
Canonical nf-kappab signal transduction
(GO:0007249)
Cellular response to osmotic stress
(GO:0071470)
Cellular response to stress
(GO:0033554)
Centrosome
(GO:0005813)
Chromatin
(GO:0000785)
Circadian regulation of gene expression
(GO:0032922)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Lymphocyte differentiation
(GO:0030098)
Myeloid dendritic cell differentiation
(GO:0043011)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of interferon-beta production
(GO:0032688)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of dna-templated transcription
(GO:0006355)
Response to cytokine
(GO:0034097)
Rhythmic process
(GO:0048511)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Synapse
(GO:0045202)
T-helper 1 cell differentiation
(GO:0045063)
T-helper 1 type immune response
(GO:0042088)
Transcription repressor complex
(GO:0017053)

Other Information

Proteins

Transcription factor RelB
Q8K220_MOUSE

Genular Protein ID: 3098534500

Symbol: RELB_MOUSE

Name: Transcription factor RelB

UniProtKB Accession Codes:

Q04863 Q8VE46

Database IDs:

Citations:

PubMed ID: 1732739

Title: RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.

PubMed ID: 1732739

DOI: 10.1128/mcb.12.2.674-684.1992

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8441398

Title: Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif.

PubMed ID: 8441398

DOI: 10.1128/mcb.13.3.1572-1582.1993

PubMed ID: 7845467

Title: Expression of relB is required for the development of thymic medulla and dendritic cells.

PubMed ID: 7845467

DOI: 10.1038/373531a0

PubMed ID: 11781828

Title: Signal-specific and phosphorylation-dependent RelB degradation: a potential mechanism of NF-kappaB control.

PubMed ID: 11781828

DOI: 10.1038/sj.onc.1204884

PubMed ID: 11931770

Title: Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor.

PubMed ID: 11931770

DOI: 10.1016/s1097-2765(02)00469-0

PubMed ID: 12874295

Title: Critical role of RelB serine 368 for dimerization and p100 stabilization.

PubMed ID: 12874295

DOI: 10.1074/jbc.m301521200

PubMed ID: 22894897

Title: The RelB subunit of NFkappaB acts as a negative regulator of circadian gene expression.

PubMed ID: 22894897

DOI: 10.4161/cc.21669

PubMed ID: 22565310

Title: Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.

PubMed ID: 22565310

DOI: 10.1172/jci60144

PubMed ID: 16154093

Title: NF-kappaB RelB forms an intertwined homodimer.

PubMed ID: 16154093

DOI: 10.1016/j.str.2005.06.018

PubMed ID: 17869269

Title: X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites.

PubMed ID: 17869269

DOI: 10.1016/j.jmb.2007.08.039

Sequence Information:

Length: 558
Mass: 60305
Checksum: AA49781A891ED7B8
Sequence:

MPSRRAARES APELGALGSS DLSSLSLTVS RTTDELEIID EYIKENGFGL DGTQLSEMPR 
LVPRGPASLS SVTLGPAAPP PPATPSWSCT LGRLVSPGPC PRPYLVITEQ PKQRGMRFRY 
ECEGRSAGSI LGESSTEASK TLPAIELRDC GGLREVEVTA CLVWKDWPHR VHPHSLVGKD 
CTDGVCRVRL RPHVSPRHSF NNLGIQCVRK KEIEAAIERK IQLGIDPYNA GSLKNHQEVD 
MNVVRICFQA SYRDQQGHLH RMDPILSEPV YDKKSTNTSE LRICRINKES GPCTGGEELY 
LLCDKVQKED ISVVFSTASW EGRADFSQAD VHRQIAIVFK TPPYEDLEIS EPVTVNVFLQ 
RLTDGVCSEP LPFTYLPRDH DSYGVDKKRK RGLPDVLGEL SSSDPHGIES KRRKKKPVFL 
DHFLPGHSSG LFLPPSALQP ADSDFFPASI SLPGLEPPGG PDLLDDGFAY DPSAPTLFTM 
LDLLPPAPPL ASAVVGSGGA GATVVESSGP EPLSLDSFAA PGPGDVGTAS LVGSNMFPNQ 
YREAAFGGGL LSPGPEAT

Genular Protein ID: 1095501461

Symbol: Q8K220_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8K220

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 555
Mass: 59948
Checksum: 12642B8A5B9E099A
Sequence:

MPSRRAARES APELGALGSS DLSSLSLTVS RTTEIIDEYI KENGFGLDGT QLSEMPRLVP 
RGPASLSSVT LGPAAPPPPA TPSWSCTLGR LVSPGPCPRP YLVITEQPKQ RGMRFRYECE 
GRSAGSILGE SSTEASKTLP AIELRDCGGL REVEVTACLV WKDWPHRVHP HSLVGKDCTD 
GVCRVRLRPH VSPRHSFNNL GIQCVRKKEI EAAIERKIQL GIDPYNAGSL KNHQEVDMNV 
VRICFQASYR DQQGHLHRMD PILSEPVYDK KSTNTSELRI CRINKESGPC TGGEELYLLC 
DKVQKEDISV VFSTASWEGR ADFSQADVHR QIAIVFKTPP YEDLEISEPV TVNVFLQRLT 
DGVCSEPLPF TYLPRDHDSY GVDKKRKRGL PDVLGELSSS DPHGIESKRR KKKPVFLDHF 
LPGHSSGLFL PPSALQPADS DFFPASISLP GLEPPGGPDL LDDGFAYDPS APTLFTMLDL 
LPPAPPLASA VVGSGGAGAT VVESSGPEPL SLDSFAAPGP GDVGTASLVG SNMFPNQYRE 
AAFGGGLLSP GPEAT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Relb

Associated with

Other Information

RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. PubMed ID: 1732739

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif. PubMed ID: 8441398

Expression of relB is required for the development of thymic medulla and dendritic cells. PubMed ID: 7845467

Signal-specific and phosphorylation-dependent RelB degradation: a potential mechanism of NF-kappaB control. PubMed ID: 11781828

Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. PubMed ID: 11931770

Critical role of RelB serine 368 for dimerization and p100 stabilization. PubMed ID: 12874295

The RelB subunit of NFkappaB acts as a negative regulator of circadian gene expression. PubMed ID: 22894897

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. PubMed ID: 22565310

NF-kappaB RelB forms an intertwined homodimer. PubMed ID: 16154093

X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites. PubMed ID: 17869269

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 1732739

PubMed ID: 16141072

PubMed ID: 15489334

PubMed ID: 8441398

PubMed ID: 7845467

PubMed ID: 11781828

PubMed ID: 11931770

PubMed ID: 12874295

PubMed ID: 22894897

PubMed ID: 22565310

PubMed ID: 16154093

PubMed ID: 17869269

PubMed ID: 15489334

PubMed ID: 19468303