Genular: Defining Cellular Identity and Function

Details for: Upf1

Gene ID: 19704

Symbol: Upf1

Ensembl ID: ENSMUSG00000058301

Description: UPF1 RNA helicase and ATPase

Associated with

Metabolism of rna
(R-MMU-8953854)
Nonsense-mediated decay (nmd)
(R-MMU-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-MMU-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-MMU-975956)
3'-utr-mediated mrna destabilization
(GO:0061158)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cell cycle phase transition
(GO:0044770)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromosome, telomeric region
(GO:0000781)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Dna duplex unwinding
(GO:0032508)
Dna repair
(GO:0006281)
Dna replication
(GO:0006260)
Double-stranded dna helicase activity
(GO:0036121)
Exon-exon junction complex
(GO:0035145)
Helicase activity
(GO:0004386)
Histone mrna catabolic process
(GO:0071044)
Hydrolase activity
(GO:0016787)
Metal ion binding
(GO:0046872)
Nuclear-transcribed mrna catabolic process
(GO:0000956)
Nuclear-transcribed mrna catabolic process, nonsense-mediated decay
(GO:0000184)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Positive regulation of mrna catabolic process
(GO:0061014)
Positive regulation of mrna cis splicing, via spliceosome
(GO:1905746)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of telomere maintenance
(GO:0032204)
Regulation of translational termination
(GO:0006449)
Rna binding
(GO:0003723)
Rna helicase activity
(GO:0003724)
Supraspliceosomal complex
(GO:0044530)
Telomere maintenance via semi-conservative replication
(GO:0032201)
Telomeric dna binding
(GO:0042162)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Up-frameshift suppressor 1 homolog

Genular Protein ID: 23542535

Symbol: RENT1_MOUSE

Name: Up-frameshift suppressor 1 homolog

UniProtKB Accession Codes:

Q9EPU0 Q3UG00 Q6GYP5 Q6PHQ5 Q8K0N4 Q99PR4

Database IDs:

Citations:

PubMed ID: 11152657

Title: Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability.

PubMed ID: 11152657

DOI: 10.1093/hmg/10.2.99

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8855285

Title: Mammalian orthologues of a yeast regulator of nonsense transcript stability.

PubMed ID: 8855285

DOI: 10.1073/pnas.93.20.10928

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 27149095

Title: Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay.

PubMed ID: 27149095

DOI: 10.1371/journal.pgen.1005857

PubMed ID: 36001654

Title: RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.

PubMed ID: 36001654

DOI: 10.1126/sciadv.abq2945

Sequence Information:

Length: 1124
Mass: 123967
Checksum: 5F1B0ED50F63C52E
Sequence:

MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTPPGG PGGAGGPGGA 
GAGGAAGQLD AQVGPEGILQ NGAVDDSVAK TSQLLAELNF EEDEEDTYYT KDLPVHACSY 
CGIHDPACVV YCNTSKKWFC NGRGNTSGSH IVNHLVRAKC KEVTLHKDGP LGETVLECYN 
CGCRNVFLLG FIPAKADSVV VLLCRQPCAS QSSLKDINWD SSQWQPLIQD RCFLSWLVKI 
PSEQEQLRAR QITAQQINKL EELWKENPSA TLEDLEKPGV DEEPQHVLLR YEDAYQYQNI 
FGPLVKLEAD YDKKLKESQT QDNITVRWDL GLNKKRIAFF TLPKTDSGNE DLVIIWLRDM 
RLMQGDEICL RYKGDLAPLW KGIGHVIKVP DNYGDEIAIE LRSSVGAPVE VTHNFQVDFV 
WKSTSFDRMQ SALKTFAVDE TSVSGYIYHK LLGHEVEDVV IKCQLPKRFT AQGLPDLNHS 
QVYAVKTVLQ RPLSLIQGPP GTGKTVTSAT IVYHLARQGN GPVLVCAPSN IAVDQLTEKI 
HQTGLKVVRL CAKSREAIDS PVSFLALHNQ IRNMDSMPEL QKLQQLKDET GELSSADEKR 
YRALKRTAER ELLMNADVIC CTCVGAGDPR LAKMQFRSIL IDESTQATEP ECMVPVVLGA 
KQLILVGDHC QLGPVVMCKK AAKAGLSQSL FERLVVLGIR PIRLQVQYRM HPALSAFPSN 
IFYEGSLQNG VTAADRVKKG FDFQWPQPDK PMFFYVTQGQ EEIASSGTSY LNRTEAANVE 
KITTKLLKAG AKPDQIGIIT PYEGQRSYLV QYMQFSGSLH TKLYQEVEIA SVDAFQGREK 
DFIILSCVRA NEHQGIGFLN DPRRLNVALT RARYGVIIVG NPKALSKQPL WNHLLSYYKE 
QKALVEGPLN NLRESLMQFS KPRKLVNTVN PGARFMTTAM YDAREAIIPG SVYDRSSQGR 
PSNMYFQTHD QISMISAGPS HVAAMNIPIP FNLVMPPMPP PGYFGQANGP AAGRGTPKTK 
TGRGGRQKNR FGLPGPSQTT LPNSQASQDV ASQPFSQGAL TQGYVSMSQP SQMSQPGLSQ 
PELSQDSYLG DEFKSQIDVA LSQDSTYQGE RAYQHGGVTG LSQY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Upf1

Associated with

Other Information

Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability. PubMed ID: 11152657

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mammalian orthologues of a yeast regulator of nonsense transcript stability. PubMed ID: 8855285

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay. PubMed ID: 27149095

RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis. PubMed ID: 36001654